Mesenchymal stem cells and extracellular matrix scaffold promote muscle regeneration by synergistically regulating macrophage polarization toward the M2 phenotype

Mesenchymal stem cells and extracellular matrix scaffold promote muscle regeneration by synergistically regulating macrophage polarization toward the M2 phenotype

Abstract Background Skeletal muscle plays an important role in the body’s physiology but there are still no effective treatments for volumetric muscle loss (VML) resulting from severe traumatic injury or tumor excision. Recent studies show that a tissue engineering strategy using a compound containi...

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Bibliographic Details
Main Authors: Xinyu Qiu, Shiyu Liu, Hao Zhang, Bin Zhu, Yuting Su, Chenxi Zheng, Rong Tian, Miao Wang, Huijuan Kuang, Xinyi Zhao, Yan Jin
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Macrophage polarization
Extracellular matrix
Tissue regeneration
Volumetric muscle loss
Online Access:http://link.springer.com/article/10.1186/s13287-018-0821-5

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