Head-Down-Tilt Bed Rest With Elevated CO2: Effects of a Pilot Spaceflight Analog on Neural Function and Performance During a Cognitive-Motor Dual Task
Spaceflight has widespread effects on human performance, including on the ability to dual task. Here, we examine how a spaceflight analog comprising 30 days of head-down-tilt bed rest (HDBR) combined with 0.5% ambient CO2 (HDBR + CO2) influences performance and functional activity of the brain durin...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.654906/full |
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| author | Aditya D. Mahadevan Aditya D. Mahadevan Kathleen E. Hupfeld Jessica K. Lee Yiri E. De Dios Igor S. Kofman Nichole E. Beltran Edwin Mulder Jacob J. Bloomberg Ajitkumar P. Mulavara Rachael D. Seidler Rachael D. Seidler |
| author_facet | Aditya D. Mahadevan Aditya D. Mahadevan Kathleen E. Hupfeld Jessica K. Lee Yiri E. De Dios Igor S. Kofman Nichole E. Beltran Edwin Mulder Jacob J. Bloomberg Ajitkumar P. Mulavara Rachael D. Seidler Rachael D. Seidler |
| author_sort | Aditya D. Mahadevan |
| collection | DOAJ |
| description | Spaceflight has widespread effects on human performance, including on the ability to dual task. Here, we examine how a spaceflight analog comprising 30 days of head-down-tilt bed rest (HDBR) combined with 0.5% ambient CO2 (HDBR + CO2) influences performance and functional activity of the brain during single and dual tasking of a cognitive and a motor task. The addition of CO2 to HDBR is thought to better mimic the conditions aboard the International Space Station. Participants completed three tasks: (1) COUNT: counting the number of times an oddball stimulus was presented among distractors; (2) TAP: tapping one of two buttons in response to a visual cue; and (3) DUAL: performing both tasks concurrently. Eleven participants (six males) underwent functional MRI (fMRI) while performing these tasks at six time points: twice before HDBR + CO2, twice during HDBR + CO2, and twice after HDBR + CO2. Behavioral measures included reaction time, standard error of reaction time, and tapping accuracy during the TAP and DUAL tasks, and the dual task cost (DTCost) of each of these measures. We also quantified DTCost of fMRI brain activation. In our previous HDBR study of 13 participants (with atmospheric CO2), subjects experienced TAP accuracy improvements during bed rest, whereas TAP accuracy declined while in the current study of HDBR + CO2. In the HDBR + CO2 subjects, we identified a region in the superior frontal gyrus that showed decreased DTCost of brain activation while in HDBR + CO2, and recovered back to baseline levels before the completion of bed rest. Compared to HDBR alone, we found different patterns of brain activation change with HDBR + CO2. HDBR + CO2 subjects had increased DTCost in the middle temporal gyrus whereas HDBR subjects had decreased DTCost in the same area. Five of the HDBR + CO2 subjects developed signs of spaceflight-associated neuro-ocular syndrome (SANS). These subjects exhibited lower baseline dual task activation and higher slopes of change during HDBR + CO2 than subjects with no signs of SANS. Collectively, this pilot study provides insight into the additional and/or interactive effects of CO2 levels during HDBR, and information regarding the impacts of this spaceflight analog environment on the neural correlates of dual tasking. |
| first_indexed | 2024-12-17T03:38:32Z |
| format | Article |
| id | doaj.art-f92f1edffb4440c684d23d5e551c3fe1 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-17T03:38:32Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-f92f1edffb4440c684d23d5e551c3fe12022-12-21T22:05:04ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-08-011210.3389/fphys.2021.654906654906Head-Down-Tilt Bed Rest With Elevated CO2: Effects of a Pilot Spaceflight Analog on Neural Function and Performance During a Cognitive-Motor Dual TaskAditya D. Mahadevan0Aditya D. Mahadevan1Kathleen E. Hupfeld2Jessica K. Lee3Yiri E. De Dios4Igor S. Kofman5Nichole E. Beltran6Edwin Mulder7Jacob J. Bloomberg8Ajitkumar P. Mulavara9Rachael D. Seidler10Rachael D. Seidler11Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United StatesCollege of Medicine, University of Florida, Gainesville, FL, United StatesDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United StatesInstitute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyKBR, Houston, TX, United StatesKBR, Houston, TX, United StatesKBR, Houston, TX, United StatesInstitute of Aerospace Medicine, German Aerospace Center, Cologne, GermanyNASA Johnson Space Center, Houston, TX, United StatesKBR, Houston, TX, United StatesDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United StatesNorman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United StatesSpaceflight has widespread effects on human performance, including on the ability to dual task. Here, we examine how a spaceflight analog comprising 30 days of head-down-tilt bed rest (HDBR) combined with 0.5% ambient CO2 (HDBR + CO2) influences performance and functional activity of the brain during single and dual tasking of a cognitive and a motor task. The addition of CO2 to HDBR is thought to better mimic the conditions aboard the International Space Station. Participants completed three tasks: (1) COUNT: counting the number of times an oddball stimulus was presented among distractors; (2) TAP: tapping one of two buttons in response to a visual cue; and (3) DUAL: performing both tasks concurrently. Eleven participants (six males) underwent functional MRI (fMRI) while performing these tasks at six time points: twice before HDBR + CO2, twice during HDBR + CO2, and twice after HDBR + CO2. Behavioral measures included reaction time, standard error of reaction time, and tapping accuracy during the TAP and DUAL tasks, and the dual task cost (DTCost) of each of these measures. We also quantified DTCost of fMRI brain activation. In our previous HDBR study of 13 participants (with atmospheric CO2), subjects experienced TAP accuracy improvements during bed rest, whereas TAP accuracy declined while in the current study of HDBR + CO2. In the HDBR + CO2 subjects, we identified a region in the superior frontal gyrus that showed decreased DTCost of brain activation while in HDBR + CO2, and recovered back to baseline levels before the completion of bed rest. Compared to HDBR alone, we found different patterns of brain activation change with HDBR + CO2. HDBR + CO2 subjects had increased DTCost in the middle temporal gyrus whereas HDBR subjects had decreased DTCost in the same area. Five of the HDBR + CO2 subjects developed signs of spaceflight-associated neuro-ocular syndrome (SANS). These subjects exhibited lower baseline dual task activation and higher slopes of change during HDBR + CO2 than subjects with no signs of SANS. Collectively, this pilot study provides insight into the additional and/or interactive effects of CO2 levels during HDBR, and information regarding the impacts of this spaceflight analog environment on the neural correlates of dual tasking.https://www.frontiersin.org/articles/10.3389/fphys.2021.654906/fullspaceflightdual taskhead-down-tilt bed rest (HDBR)CO2spaceflight-associated neuro-ocular syndrome (SANS) |
| spellingShingle | Aditya D. Mahadevan Aditya D. Mahadevan Kathleen E. Hupfeld Jessica K. Lee Yiri E. De Dios Igor S. Kofman Nichole E. Beltran Edwin Mulder Jacob J. Bloomberg Ajitkumar P. Mulavara Rachael D. Seidler Rachael D. Seidler Head-Down-Tilt Bed Rest With Elevated CO2: Effects of a Pilot Spaceflight Analog on Neural Function and Performance During a Cognitive-Motor Dual Task Frontiers in Physiology spaceflight dual task head-down-tilt bed rest (HDBR) CO2 spaceflight-associated neuro-ocular syndrome (SANS) |
| title | Head-Down-Tilt Bed Rest With Elevated CO2: Effects of a Pilot Spaceflight Analog on Neural Function and Performance During a Cognitive-Motor Dual Task |
| title_full | Head-Down-Tilt Bed Rest With Elevated CO2: Effects of a Pilot Spaceflight Analog on Neural Function and Performance During a Cognitive-Motor Dual Task |
| title_fullStr | Head-Down-Tilt Bed Rest With Elevated CO2: Effects of a Pilot Spaceflight Analog on Neural Function and Performance During a Cognitive-Motor Dual Task |
| title_full_unstemmed | Head-Down-Tilt Bed Rest With Elevated CO2: Effects of a Pilot Spaceflight Analog on Neural Function and Performance During a Cognitive-Motor Dual Task |
| title_short | Head-Down-Tilt Bed Rest With Elevated CO2: Effects of a Pilot Spaceflight Analog on Neural Function and Performance During a Cognitive-Motor Dual Task |
| title_sort | head down tilt bed rest with elevated co2 effects of a pilot spaceflight analog on neural function and performance during a cognitive motor dual task |
| topic | spaceflight dual task head-down-tilt bed rest (HDBR) CO2 spaceflight-associated neuro-ocular syndrome (SANS) |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.654906/full |
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