Home-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot study
Abstract Background The prevalence of osteopenia and osteoporosis is higher in patients with chronic kidney disease than that in the general population. Although physical exercise prevents bone loss in hemodialysis (HD) patients, previous studies have not focused on peritoneal dialysis (PD) patients...
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-021-02289-y |
| _version_ | 1818741982900518912 |
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| author | Kumi Watanabe Yuka Kamijo Mai Yanagi Yoshitaka Ishibashi Taku Harada Masahiro Kohzuki |
| author_facet | Kumi Watanabe Yuka Kamijo Mai Yanagi Yoshitaka Ishibashi Taku Harada Masahiro Kohzuki |
| author_sort | Kumi Watanabe |
| collection | DOAJ |
| description | Abstract Background The prevalence of osteopenia and osteoporosis is higher in patients with chronic kidney disease than that in the general population. Although physical exercise prevents bone loss in hemodialysis (HD) patients, previous studies have not focused on peritoneal dialysis (PD) patients. Therefore, we aimed to evaluate the effects of home-based exercise on bone mineral density (BMD) in patients with PD. Methods Stable outpatients undergoing PD were randomly assigned to the intervention group (n = 26; male, 20; median age, 66 years) or usual-care group (n = 27; male, 21; median age, 64 years). Patients in the intervention group performed home-based exercises (resistance exercise, stretching, and aerobic exercise such as walking) for 6 months, whereas those in the usual-care group performed stretching and their usual physical activity. Based on dual X-ray absorptiometry, the primary outcomes were the BMD data of the lumbar spine and proximal femoral neck. Secondary outcomes included physical function and physical activity. Pre- and post-intervention values were compared. Results There was no significant within-group change in the BMD of the lumbar spine, femoral neck, and hip after 6 months of the exercise program. The intervention group had significantly improved 30-s chair-stand test, 6-min walk test, and physical activity results. Conclusions Home-based exercises in patients with PD did not improve BMD at any of the sites evaluated. Improvement in physical function and physical activity may reduce the risk of falls in patients with PD. Trial registration UMIN Clinical Trials Registry, UMIN000041678 . Registered September 4, 2020; retrospectively registered. |
| first_indexed | 2024-12-18T02:05:17Z |
| format | Article |
| id | doaj.art-f930c07064694228a5696a5f0f850278 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-18T02:05:17Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-f930c07064694228a5696a5f0f8502782022-12-21T21:24:37ZengBMCBMC Nephrology1471-23692021-03-012211910.1186/s12882-021-02289-yHome-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot studyKumi Watanabe0Yuka Kamijo1Mai Yanagi2Yoshitaka Ishibashi3Taku Harada4Masahiro Kohzuki5Department of Nephrology, Japanese Red Cross Medical CenterDepartment of Nephrology, Japanese Red Cross Medical CenterDepartment of Nephrology, Japanese Red Cross Medical CenterDepartment of Nephrology, Japanese Red Cross Medical CenterDepartment of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of MedicineDepartment of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of MedicineAbstract Background The prevalence of osteopenia and osteoporosis is higher in patients with chronic kidney disease than that in the general population. Although physical exercise prevents bone loss in hemodialysis (HD) patients, previous studies have not focused on peritoneal dialysis (PD) patients. Therefore, we aimed to evaluate the effects of home-based exercise on bone mineral density (BMD) in patients with PD. Methods Stable outpatients undergoing PD were randomly assigned to the intervention group (n = 26; male, 20; median age, 66 years) or usual-care group (n = 27; male, 21; median age, 64 years). Patients in the intervention group performed home-based exercises (resistance exercise, stretching, and aerobic exercise such as walking) for 6 months, whereas those in the usual-care group performed stretching and their usual physical activity. Based on dual X-ray absorptiometry, the primary outcomes were the BMD data of the lumbar spine and proximal femoral neck. Secondary outcomes included physical function and physical activity. Pre- and post-intervention values were compared. Results There was no significant within-group change in the BMD of the lumbar spine, femoral neck, and hip after 6 months of the exercise program. The intervention group had significantly improved 30-s chair-stand test, 6-min walk test, and physical activity results. Conclusions Home-based exercises in patients with PD did not improve BMD at any of the sites evaluated. Improvement in physical function and physical activity may reduce the risk of falls in patients with PD. Trial registration UMIN Clinical Trials Registry, UMIN000041678 . Registered September 4, 2020; retrospectively registered.https://doi.org/10.1186/s12882-021-02289-yOsteoporosisPhysical functionPhysical activityFall prevention |
| spellingShingle | Kumi Watanabe Yuka Kamijo Mai Yanagi Yoshitaka Ishibashi Taku Harada Masahiro Kohzuki Home-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot study BMC Nephrology Osteoporosis Physical function Physical activity Fall prevention |
| title | Home-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot study |
| title_full | Home-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot study |
| title_fullStr | Home-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot study |
| title_full_unstemmed | Home-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot study |
| title_short | Home-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot study |
| title_sort | home based exercise and bone mineral density in peritoneal dialysis patients a randomized pilot study |
| topic | Osteoporosis Physical function Physical activity Fall prevention |
| url | https://doi.org/10.1186/s12882-021-02289-y |
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