IL-6 Enhances the Negative Impact of Cortisol on Cognition among Community-Dwelling Older People without Dementia
There is growing evidence that high basal cortisol levels and systemic inflammation independently contribute to cognitive decline among older people without dementia. The present cross-sectional study examined (a) the potential synergistic effect of cortisol levels and systemic inflammation on execu...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Healthcare |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9032/11/7/951 |
| _version_ | 1797607993256181760 |
|---|---|
| author | Eirini Koutentaki Maria Basta Despina Antypa Ioannis Zaganas Symeon Panagiotakis Panagiotis Simos Alexandros N. Vgontzas |
| author_facet | Eirini Koutentaki Maria Basta Despina Antypa Ioannis Zaganas Symeon Panagiotakis Panagiotis Simos Alexandros N. Vgontzas |
| author_sort | Eirini Koutentaki |
| collection | DOAJ |
| description | There is growing evidence that high basal cortisol levels and systemic inflammation independently contribute to cognitive decline among older people without dementia. The present cross-sectional study examined (a) the potential synergistic effect of cortisol levels and systemic inflammation on executive function and (b) whether this effect is more prominent among older people with mild cognitive impairment (MCI). A sub-sample of 99 patients with MCI and 84 older people without cognitive impairment (CNI) (aged 73.8 ± 7.0 years) were recruited from a large population-based cohort in Crete, Greece, and underwent comprehensive neuropsychiatric and neuropsychological evaluation and a single morning measurement of cortisol and IL-6 plasma levels. Using moderated regression models, we found that the relation between cortisol and executive function in the total sample was moderated by IL-6 levels (<i>b</i> = −0.994, <i>p</i> = 0.044) and diagnostic group separately (<i>b</i> = −0.632, <i>p</i> < 0.001). Moreover, the interaction between cortisol and IL-6 levels was significant only among persons with MCI (<i>b</i> = −0.562, <i>p</i> < 0.001). The synergistic effect of stress hormones and systemic inflammation on cognitive status appears to be stronger among older people who already display signs of cognitive decline. Targeting hypercortisolemia and inflammation may be a promising strategy toward improving the course of cognitive decline. |
| first_indexed | 2024-03-11T05:37:23Z |
| format | Article |
| id | doaj.art-f932051fec774ac083d9dc576b32c888 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-11T05:37:23Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-f932051fec774ac083d9dc576b32c8882023-11-17T16:43:20ZengMDPI AGHealthcare2227-90322023-03-0111795110.3390/healthcare11070951IL-6 Enhances the Negative Impact of Cortisol on Cognition among Community-Dwelling Older People without DementiaEirini Koutentaki0Maria Basta1Despina Antypa2Ioannis Zaganas3Symeon Panagiotakis4Panagiotis Simos5Alexandros N. Vgontzas6Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Crete, Voutes, Heraklion, 71003 Crete, GreeceDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of Crete, Voutes, Heraklion, 71003 Crete, GreeceDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of Crete, Voutes, Heraklion, 71003 Crete, GreeceDepartment of Neurology, School of Medicine, University of Crete, Voutes, Heraklion, 71003 Crete, GreeceDepartment of Internal Medicine, University Hospital of Heraklion, Panepistimiou Ave., Heraklion, 71500 Crete, GreeceDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of Crete, Voutes, Heraklion, 71003 Crete, GreeceDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of Crete, Voutes, Heraklion, 71003 Crete, GreeceThere is growing evidence that high basal cortisol levels and systemic inflammation independently contribute to cognitive decline among older people without dementia. The present cross-sectional study examined (a) the potential synergistic effect of cortisol levels and systemic inflammation on executive function and (b) whether this effect is more prominent among older people with mild cognitive impairment (MCI). A sub-sample of 99 patients with MCI and 84 older people without cognitive impairment (CNI) (aged 73.8 ± 7.0 years) were recruited from a large population-based cohort in Crete, Greece, and underwent comprehensive neuropsychiatric and neuropsychological evaluation and a single morning measurement of cortisol and IL-6 plasma levels. Using moderated regression models, we found that the relation between cortisol and executive function in the total sample was moderated by IL-6 levels (<i>b</i> = −0.994, <i>p</i> = 0.044) and diagnostic group separately (<i>b</i> = −0.632, <i>p</i> < 0.001). Moreover, the interaction between cortisol and IL-6 levels was significant only among persons with MCI (<i>b</i> = −0.562, <i>p</i> < 0.001). The synergistic effect of stress hormones and systemic inflammation on cognitive status appears to be stronger among older people who already display signs of cognitive decline. Targeting hypercortisolemia and inflammation may be a promising strategy toward improving the course of cognitive decline.https://www.mdpi.com/2227-9032/11/7/951basal cortisolinflammatory markersolder peopleexecutive functionMCI |
| spellingShingle | Eirini Koutentaki Maria Basta Despina Antypa Ioannis Zaganas Symeon Panagiotakis Panagiotis Simos Alexandros N. Vgontzas IL-6 Enhances the Negative Impact of Cortisol on Cognition among Community-Dwelling Older People without Dementia Healthcare basal cortisol inflammatory markers older people executive function MCI |
| title | IL-6 Enhances the Negative Impact of Cortisol on Cognition among Community-Dwelling Older People without Dementia |
| title_full | IL-6 Enhances the Negative Impact of Cortisol on Cognition among Community-Dwelling Older People without Dementia |
| title_fullStr | IL-6 Enhances the Negative Impact of Cortisol on Cognition among Community-Dwelling Older People without Dementia |
| title_full_unstemmed | IL-6 Enhances the Negative Impact of Cortisol on Cognition among Community-Dwelling Older People without Dementia |
| title_short | IL-6 Enhances the Negative Impact of Cortisol on Cognition among Community-Dwelling Older People without Dementia |
| title_sort | il 6 enhances the negative impact of cortisol on cognition among community dwelling older people without dementia |
| topic | basal cortisol inflammatory markers older people executive function MCI |
| url | https://www.mdpi.com/2227-9032/11/7/951 |
| work_keys_str_mv | AT eirinikoutentaki il6enhancesthenegativeimpactofcortisoloncognitionamongcommunitydwellingolderpeoplewithoutdementia AT mariabasta il6enhancesthenegativeimpactofcortisoloncognitionamongcommunitydwellingolderpeoplewithoutdementia AT despinaantypa il6enhancesthenegativeimpactofcortisoloncognitionamongcommunitydwellingolderpeoplewithoutdementia AT ioanniszaganas il6enhancesthenegativeimpactofcortisoloncognitionamongcommunitydwellingolderpeoplewithoutdementia AT symeonpanagiotakis il6enhancesthenegativeimpactofcortisoloncognitionamongcommunitydwellingolderpeoplewithoutdementia AT panagiotissimos il6enhancesthenegativeimpactofcortisoloncognitionamongcommunitydwellingolderpeoplewithoutdementia AT alexandrosnvgontzas il6enhancesthenegativeimpactofcortisoloncognitionamongcommunitydwellingolderpeoplewithoutdementia |