Novel Therapeutic Savior for Osteosarcoma: The Endorsement of Ferroptosis
Ferroptosis has recently been discovered as an iron-dependent and non-apoptotic regulated mechanism of cell death. The induction of ferroptosis in tumor cells improves tumor treatment, making it a current research hotspot. Mechanistically, it starts by lipid peroxidation, iron accumulation, reactive...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.746030/full |
| _version_ | 1818311377644683264 |
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| author | Cheng Qiu Cheng Qiu Tianyi Liu Dan Luo Dongyang Luan Lin Cheng Lin Cheng Songgang Wang |
| author_facet | Cheng Qiu Cheng Qiu Tianyi Liu Dan Luo Dongyang Luan Lin Cheng Lin Cheng Songgang Wang |
| author_sort | Cheng Qiu |
| collection | DOAJ |
| description | Ferroptosis has recently been discovered as an iron-dependent and non-apoptotic regulated mechanism of cell death. The induction of ferroptosis in tumor cells improves tumor treatment, making it a current research hotspot. Mechanistically, it starts by lipid peroxidation, iron accumulation, reactive oxygen species (ROS) production, and glutathione deprivation, highlighting novel treatment opportunities for many tumors and neurodegenerative disorders. Several tumor cell lines are resistant to ferroptosis inducers, even when the ferroptosis key enzyme glutathione peroxidase 4 (GPX4) is blocked, indicating that other important elements are also involved in this process. Ferroptosis-suppressor-protein 1 (FSP1) was discovered to be one of these elements in addition to a few others such as ferroptotic gatekeepers like GTP cyclohydrolase 1 (GCH1) and dihydroorotate dehydrogenase (DHODH). Osteosarcoma is the most common primary malignant bone tumor observed most frequently in children and adolescents. Several studies demonstrated that ferroptosis plays a critical role in the treatment of osteosarcoma, in particular drug-resistant osteosarcoma cells. We outlined four primary regulators involved in ferroptosis in this article, reviewed previously published studies of ferroptosis in osteosarcoma to provide covert insights about osteosarcoma treatment, and highlighted several critical issues to point out future research possibilities. |
| first_indexed | 2024-12-13T08:01:00Z |
| format | Article |
| id | doaj.art-f932f61094a04362b444db19ed111ea9 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T08:01:00Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-f932f61094a04362b444db19ed111ea92022-12-21T23:54:27ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-03-011210.3389/fonc.2022.746030746030Novel Therapeutic Savior for Osteosarcoma: The Endorsement of FerroptosisCheng Qiu0Cheng Qiu1Tianyi Liu2Dan Luo3Dongyang Luan4Lin Cheng5Lin Cheng6Songgang Wang7Department of Orthopaedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaCheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaCollege of Stomatology, Qingdao University, Qingdao, ChinaCheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Orthopaedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Orthopaedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaFerroptosis has recently been discovered as an iron-dependent and non-apoptotic regulated mechanism of cell death. The induction of ferroptosis in tumor cells improves tumor treatment, making it a current research hotspot. Mechanistically, it starts by lipid peroxidation, iron accumulation, reactive oxygen species (ROS) production, and glutathione deprivation, highlighting novel treatment opportunities for many tumors and neurodegenerative disorders. Several tumor cell lines are resistant to ferroptosis inducers, even when the ferroptosis key enzyme glutathione peroxidase 4 (GPX4) is blocked, indicating that other important elements are also involved in this process. Ferroptosis-suppressor-protein 1 (FSP1) was discovered to be one of these elements in addition to a few others such as ferroptotic gatekeepers like GTP cyclohydrolase 1 (GCH1) and dihydroorotate dehydrogenase (DHODH). Osteosarcoma is the most common primary malignant bone tumor observed most frequently in children and adolescents. Several studies demonstrated that ferroptosis plays a critical role in the treatment of osteosarcoma, in particular drug-resistant osteosarcoma cells. We outlined four primary regulators involved in ferroptosis in this article, reviewed previously published studies of ferroptosis in osteosarcoma to provide covert insights about osteosarcoma treatment, and highlighted several critical issues to point out future research possibilities.https://www.frontiersin.org/articles/10.3389/fonc.2022.746030/fullferroptosisosteosarcomadrug resistanceGPX4FSP1GCH1 |
| spellingShingle | Cheng Qiu Cheng Qiu Tianyi Liu Dan Luo Dongyang Luan Lin Cheng Lin Cheng Songgang Wang Novel Therapeutic Savior for Osteosarcoma: The Endorsement of Ferroptosis Frontiers in Oncology ferroptosis osteosarcoma drug resistance GPX4 FSP1 GCH1 |
| title | Novel Therapeutic Savior for Osteosarcoma: The Endorsement of Ferroptosis |
| title_full | Novel Therapeutic Savior for Osteosarcoma: The Endorsement of Ferroptosis |
| title_fullStr | Novel Therapeutic Savior for Osteosarcoma: The Endorsement of Ferroptosis |
| title_full_unstemmed | Novel Therapeutic Savior for Osteosarcoma: The Endorsement of Ferroptosis |
| title_short | Novel Therapeutic Savior for Osteosarcoma: The Endorsement of Ferroptosis |
| title_sort | novel therapeutic savior for osteosarcoma the endorsement of ferroptosis |
| topic | ferroptosis osteosarcoma drug resistance GPX4 FSP1 GCH1 |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.746030/full |
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