New aspects in shear-wave elastography of prostate cancer
Aim: This study was designed to evaluate the performance of shear-wave elastography as a diagnostic tool for prostate cancer in a larger cohort of patients than previously reported. Patients and methods: Seventy-three patients with suspected prostate carcinoma were investigated by ultrasound elas...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2015-03-01
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| Series: | Journal of Ultrasonography |
| Subjects: | |
| Online Access: | http://jultrason.pl/index.php/issues/volume-15-no-60/new-aspects-in-shear-wave-elastography-of-prostate-cancer?aid=316 |
| _version_ | 1818506436742742016 |
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| author | Markus Porsch Johann Jakob Wendler Uwe-Bernd Liehr Anke Lux Martin Schostak Maciej Pech |
| author_facet | Markus Porsch Johann Jakob Wendler Uwe-Bernd Liehr Anke Lux Martin Schostak Maciej Pech |
| author_sort | Markus Porsch |
| collection | DOAJ |
| description | Aim: This study was designed to evaluate the performance of shear-wave elastography
as a diagnostic tool for prostate cancer in a larger cohort of patients than previously
reported. Patients and methods: Seventy-three patients with suspected prostate carcinoma
were investigated by ultrasound elastography followed by directed biopsy. The elastographic
and histological results for all biopsies were compared. Results: After exclusion
of invalid and non-assessable results, 794 samples were obtained for which both a histological
assessment and an elastometric result (tissue stiffness in kPa) were available:
according to the histology 589 were benign and 205 were malignant. Tissue elasticity was
found to be weakly correlated with patient’s age, PSA level and gland volume. ROC analysis
showed that, for the set of results acquired, elastometry did not fulfil literature claims
that it could identify malignant neoplasia with high sensitivity and specificity. However, it
did show promise in distinguishing between Gleason scores ≤6 and >6 when malignancy
had already been identifi ed. Unexpected observations were the fi nding of a smaller proportion
of tumours in the lateral regions of the prostate than generally expected, and also
the observation that the elasticity of benign prostate tissue is region-sensitive, the tissue
being stiffest in the basal region and more elastic at the apex. Conclusions: Shear-wave
elastography was found to be a poor predictor of malignancy, but for malignant lesions
an elasticity cut-off of 80 kPa allowed a fairly reliable distinction between lesions with
Gleason ≤6 and those with Gleason >6. We demonstrate an increase in elasticity of benign
prostate tissue from the basal to the apical region. |
| first_indexed | 2024-12-10T22:04:31Z |
| format | Article |
| id | doaj.art-f933ce30d0314abc9dd52058db7ad790 |
| institution | Directory Open Access Journal |
| issn | 2084-8404 2451-070X |
| language | English |
| last_indexed | 2024-12-10T22:04:31Z |
| publishDate | 2015-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Ultrasonography |
| spelling | doaj.art-f933ce30d0314abc9dd52058db7ad7902022-12-22T01:31:47ZengSciendoJournal of Ultrasonography2084-84042451-070X2015-03-01156051410.15557/JoU.2015.0001New aspects in shear-wave elastography of prostate cancerMarkus Porsch0Johann Jakob Wendler1Uwe-Bernd Liehr2Anke Lux3Martin Schostak4Maciej Pech5Klinik für Urologie und Kinderurologie, Medizinische Fakultät der Otto-von-GuerickeUniversität Magdeburg, GermanyKlinik für Urologie und Kinderurologie, Medizinische Fakultät der Otto-von-GuerickeUniversität Magdeburg, GermanyKlinik für Urologie und Kinderurologie, Medizinische Fakultät der Otto-von-GuerickeUniversität Magdeburg, GermanyInstitut für Biometrie und Medizinische Informatik, Medizinische Fakultät, Otto-von-Guericke-Universität Magdeburg, GermanyKlinik für Urologie und Kinderurologie, Medizinische Fakultät der Otto-von-GuerickeUniversität Magdeburg, GermanyKlinik für Radiologie und Nuklearmedizin, Medizinische Fakultät der Otto-vonGuericke-Universität Magdeburg, Germany; Medical University of Gdansk, 2nd Department of Radiology, Gdańsk, PolandAim: This study was designed to evaluate the performance of shear-wave elastography as a diagnostic tool for prostate cancer in a larger cohort of patients than previously reported. Patients and methods: Seventy-three patients with suspected prostate carcinoma were investigated by ultrasound elastography followed by directed biopsy. The elastographic and histological results for all biopsies were compared. Results: After exclusion of invalid and non-assessable results, 794 samples were obtained for which both a histological assessment and an elastometric result (tissue stiffness in kPa) were available: according to the histology 589 were benign and 205 were malignant. Tissue elasticity was found to be weakly correlated with patient’s age, PSA level and gland volume. ROC analysis showed that, for the set of results acquired, elastometry did not fulfil literature claims that it could identify malignant neoplasia with high sensitivity and specificity. However, it did show promise in distinguishing between Gleason scores ≤6 and >6 when malignancy had already been identifi ed. Unexpected observations were the fi nding of a smaller proportion of tumours in the lateral regions of the prostate than generally expected, and also the observation that the elasticity of benign prostate tissue is region-sensitive, the tissue being stiffest in the basal region and more elastic at the apex. Conclusions: Shear-wave elastography was found to be a poor predictor of malignancy, but for malignant lesions an elasticity cut-off of 80 kPa allowed a fairly reliable distinction between lesions with Gleason ≤6 and those with Gleason >6. We demonstrate an increase in elasticity of benign prostate tissue from the basal to the apical region.http://jultrason.pl/index.php/issues/volume-15-no-60/new-aspects-in-shear-wave-elastography-of-prostate-cancer?aid=316prostate cancershear waveelastographyultrasoundprostate biopsy |
| spellingShingle | Markus Porsch Johann Jakob Wendler Uwe-Bernd Liehr Anke Lux Martin Schostak Maciej Pech New aspects in shear-wave elastography of prostate cancer Journal of Ultrasonography prostate cancer shear wave elastography ultrasound prostate biopsy |
| title | New aspects in shear-wave elastography of prostate cancer |
| title_full | New aspects in shear-wave elastography of prostate cancer |
| title_fullStr | New aspects in shear-wave elastography of prostate cancer |
| title_full_unstemmed | New aspects in shear-wave elastography of prostate cancer |
| title_short | New aspects in shear-wave elastography of prostate cancer |
| title_sort | new aspects in shear wave elastography of prostate cancer |
| topic | prostate cancer shear wave elastography ultrasound prostate biopsy |
| url | http://jultrason.pl/index.php/issues/volume-15-no-60/new-aspects-in-shear-wave-elastography-of-prostate-cancer?aid=316 |
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