The Challenging Path to Diagnosing Extraintestinal Amoebiasis: A Case Report of an HIV-Infected Patient
Xiaofeng Li,1,* Cha Chen,1,* Luyuan Tong,1 Qun Gao,1 Wenxian Chen,2 Guangde Zhou,3 Zhaowei Tong,1 Weihong Wang1,4 1Department of Infectious Diseases, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang Province, People’s Republic of China; 2Depart...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-12-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/the-challenging-path-to-diagnosing-extraintestinal-amoebiasis-a-case-r-peer-reviewed-fulltext-article-IDR |
| _version_ | 1797397651482738688 |
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| author | Li X Chen C Tong L Gao Q Chen W Zhou G Tong Z Wang W |
| author_facet | Li X Chen C Tong L Gao Q Chen W Zhou G Tong Z Wang W |
| author_sort | Li X |
| collection | DOAJ |
| description | Xiaofeng Li,1,* Cha Chen,1,* Luyuan Tong,1 Qun Gao,1 Wenxian Chen,2 Guangde Zhou,3 Zhaowei Tong,1 Weihong Wang1,4 1Department of Infectious Diseases, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang Province, People’s Republic of China; 2Department of Ultrasonography, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang Province, People’s Republic of China; 3Department of Pathology, Affiliated Beijing You An Hospital, Capital Medical University, Beijing, People’s Republic of China; 4Huzhou Key Laboratory of Precision Medicine Research and Translation for Infectious Diseases, Huzhou, Zhejiang Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Weihong Wang, Email hzwwh0606@163.comBackground: Amoebiasis, an infectious disease caused by the parasitic protozoan E. histolytica, is easily misdiagnosed due to its declining incidence and atypical symptoms.Case Presentation: A 31-year-old male presented to the hospital with dyspnea and inability to lie flat. Imaging studies indicated a large amount of pleural effusion on the right side and multiple huge cysts in the liver. The patient underwent liver tumor resection surgery at another hospital due to suspected malignancy, but no evidence of relevant malignant tumors was found in the pathological examination. Subsequently, we performed metagenomic next-generation sequencing on the liver drainage fluid and obtained liver pathology slides from the hospital where the surgery was performed at that time. Both of them confirmed the diagnosis of amoebic infection. Empirical treatment with metronidazole was initiated before the diagnosis was confirmed, along with symptomatic treatments such as thoracic drainage and liver drainage. Eventually, the patient’s condition improved and he was discharged smoothly.Conclusion: In order to avoid misdiagnosis of amoebiasis, thoroughly inquiring about the patient’s medical history, shifting perspectives and continuing investigating are necessary when one diagnostic approach proves ineffective. Besides, interdisciplinary collaboration and persistent efforts are crucial for accurate diagnosis.Keywords: amebiasis, amoebic abscess, diagnosis, HIV, metagenomic next-generation sequencing, metronidazole |
| first_indexed | 2024-03-09T01:14:13Z |
| format | Article |
| id | doaj.art-f935bba47daa4f52a5e345bec5544a6a |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-03-09T01:14:13Z |
| publishDate | 2023-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-f935bba47daa4f52a5e345bec5544a6a2023-12-10T17:08:56ZengDove Medical PressInfection and Drug Resistance1178-69732023-12-01Volume 167569757488893The Challenging Path to Diagnosing Extraintestinal Amoebiasis: A Case Report of an HIV-Infected PatientLi XChen CTong LGao QChen WZhou GTong ZWang WXiaofeng Li,1,* Cha Chen,1,* Luyuan Tong,1 Qun Gao,1 Wenxian Chen,2 Guangde Zhou,3 Zhaowei Tong,1 Weihong Wang1,4 1Department of Infectious Diseases, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang Province, People’s Republic of China; 2Department of Ultrasonography, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang Province, People’s Republic of China; 3Department of Pathology, Affiliated Beijing You An Hospital, Capital Medical University, Beijing, People’s Republic of China; 4Huzhou Key Laboratory of Precision Medicine Research and Translation for Infectious Diseases, Huzhou, Zhejiang Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Weihong Wang, Email hzwwh0606@163.comBackground: Amoebiasis, an infectious disease caused by the parasitic protozoan E. histolytica, is easily misdiagnosed due to its declining incidence and atypical symptoms.Case Presentation: A 31-year-old male presented to the hospital with dyspnea and inability to lie flat. Imaging studies indicated a large amount of pleural effusion on the right side and multiple huge cysts in the liver. The patient underwent liver tumor resection surgery at another hospital due to suspected malignancy, but no evidence of relevant malignant tumors was found in the pathological examination. Subsequently, we performed metagenomic next-generation sequencing on the liver drainage fluid and obtained liver pathology slides from the hospital where the surgery was performed at that time. Both of them confirmed the diagnosis of amoebic infection. Empirical treatment with metronidazole was initiated before the diagnosis was confirmed, along with symptomatic treatments such as thoracic drainage and liver drainage. Eventually, the patient’s condition improved and he was discharged smoothly.Conclusion: In order to avoid misdiagnosis of amoebiasis, thoroughly inquiring about the patient’s medical history, shifting perspectives and continuing investigating are necessary when one diagnostic approach proves ineffective. Besides, interdisciplinary collaboration and persistent efforts are crucial for accurate diagnosis.Keywords: amebiasis, amoebic abscess, diagnosis, HIV, metagenomic next-generation sequencing, metronidazolehttps://www.dovepress.com/the-challenging-path-to-diagnosing-extraintestinal-amoebiasis-a-case-r-peer-reviewed-fulltext-article-IDRamebiasis，amoebic abscess，diagnosis，hiv，metagenomic next-generation sequencing，metronidazole |
| spellingShingle | Li X Chen C Tong L Gao Q Chen W Zhou G Tong Z Wang W The Challenging Path to Diagnosing Extraintestinal Amoebiasis: A Case Report of an HIV-Infected Patient Infection and Drug Resistance amebiasis，amoebic abscess，diagnosis，hiv，metagenomic next-generation sequencing，metronidazole |
| title | The Challenging Path to Diagnosing Extraintestinal Amoebiasis: A Case Report of an HIV-Infected Patient |
| title_full | The Challenging Path to Diagnosing Extraintestinal Amoebiasis: A Case Report of an HIV-Infected Patient |
| title_fullStr | The Challenging Path to Diagnosing Extraintestinal Amoebiasis: A Case Report of an HIV-Infected Patient |
| title_full_unstemmed | The Challenging Path to Diagnosing Extraintestinal Amoebiasis: A Case Report of an HIV-Infected Patient |
| title_short | The Challenging Path to Diagnosing Extraintestinal Amoebiasis: A Case Report of an HIV-Infected Patient |
| title_sort | challenging path to diagnosing extraintestinal amoebiasis a case report of an hiv infected patient |
| topic | amebiasis，amoebic abscess，diagnosis，hiv，metagenomic next-generation sequencing，metronidazole |
| url | https://www.dovepress.com/the-challenging-path-to-diagnosing-extraintestinal-amoebiasis-a-case-r-peer-reviewed-fulltext-article-IDR |
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