The anticancer potential of chemical constituents of Moringa oleifera targeting CDK-2 inhibition in estrogen receptor positive breast cancer using in-silico and in vitro approches

The anticancer potential of chemical constituents of Moringa oleifera targeting CDK-2 inhibition in estrogen receptor positive breast cancer using in-silico and in vitro approches

Abstract Most of the breast cancers are estrogen receptor-positive recurring with a steady rate of up to 20 years dysregulating the normal cell cycle. Dinaciclib is still in clinical trials and considered as a research drug against such cancers targeting CDK2. The major goal of this study was to ide...

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Bibliographic Details
Main Authors:	Rida Sultan, Abrar Ahmed, Li Wei, Hamid Saeed, Muhammad Islam, Muhammad Ishaq
Format:	Article
Language:	English
Published:	BMC 2023-11-01
Series:	BMC Complementary Medicine and Therapies
Subjects:	CDK2 ER+ Breast cancer Molecular Docking MM-GBSA Molecular Dynamic Simulations MTT assay
Online Access:	https://doi.org/10.1186/s12906-023-04198-z

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