Characteristics, Outcomes, and Clinical Indicators of Bloodstream Infections in Neutropenic Patients with Hematological Malignancies: A 7-Year Retrospective Study
Shuyun Wang,1 Yan Song,1 Nan Shi,1,2 Donghong Yin,1 Jianbang Kang,1 Wanni Cai,2 Jinju Duan1 1Department of Pharmacy, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Department of Pharmacy, School of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi, Peo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-07-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/characteristics-outcomes-and-clinical-indicators-of-bloodstream-infect-peer-reviewed-fulltext-article-IDR |
| _version_ | 1797784258345959424 |
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| author | Wang S Song Y Shi N Yin D Kang J Cai W Duan J |
| author_facet | Wang S Song Y Shi N Yin D Kang J Cai W Duan J |
| author_sort | Wang S |
| collection | DOAJ |
| description | Shuyun Wang,1 Yan Song,1 Nan Shi,1,2 Donghong Yin,1 Jianbang Kang,1 Wanni Cai,2 Jinju Duan1 1Department of Pharmacy, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Department of Pharmacy, School of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of ChinaCorrespondence: Jinju Duan, Department of Pharmacy, Second Hospital of Shanxi Medical University, Wuyi Road, Xinghualing District, Taiyuan, Shanxi, People’s Republic of China, Tel +86 13834653172, Email duanjinju@163.comPurpose: The aim of this study was to investigate the current epidemiology, its changes during the study years, and inflammatory biomarkers of bacterial bloodstream infections (BSIs) in neutropenic patients with hematological malignancies. We assessed mortality risk factors and multidrug-resistant (MDR) gram-negative BSI predictors.Patients and Methods: We conducted a retrospective study from January 2015 to December 2021, which included adult neutropenic oncohematological patients with confirmed BSIs. We used univariable and multivariable analyses to analyze the risk factors. Each index’s reliability for bacterial BSI diagnosis was assessed using the receiver-operating characteristic curve and area under the curve.Results: A total of 514 isolates were obtained from the 452 patients. The average mortality was 17.71%. Gram-negative organisms were the predominant causes of BSI. Escherichia coli was the most common microorganism (49.90%). The overall variation trend of the isolation rate of MDR and carbapenem-resistant gram-negative bacteria increased. Multivariate analysis indicated that: 1) neutropenia that lasted for more than 7 days, patients ≥ 60 years of age, septic shock, hospitalization for > 20 days, BSI with a carbapenem-resistant strain, and treatment with linezolid or vancomycin in infections lasting less than 30 days were independent mortality risk factors; 2) severe neutropenia exceeding 7 days, unreasonable empirical therapy, and receipt of aminoglycosides or 3rd or 4th generation cephalosporins in infections lasting less than 30 days were independent risk factors of MDR gram-negative bacteria. Procalcitonin, absolute neutrophil count, and white blood cell indicate higher diagnostic accuracy for BSIs. Moreover, bacteria time to detection was better at differentiating Gram-negative and Gram-positive bacterial infections.Conclusion: We analyzed the risk factors for BSI neutropenic patients with hematological malignancies, the distribution of bacteria, antibiotic resistance, and the changes in clinical parameters. This single-center retrospective study may provide clinicians with novel insights into the diagnosis and treatment of BSI to improve future clinical outcomes.Keywords: bloodstream infection, neutropenia, hematological malignancy, pathogens distribution, antibiotic susceptibility, risk factors |
| first_indexed | 2024-03-13T00:37:20Z |
| format | Article |
| id | doaj.art-f938c2ec60874d77935f8b991b7dc847 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-03-13T00:37:20Z |
| publishDate | 2023-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-f938c2ec60874d77935f8b991b7dc8472023-07-09T19:03:31ZengDove Medical PressInfection and Drug Resistance1178-69732023-07-01Volume 164471448785005Characteristics, Outcomes, and Clinical Indicators of Bloodstream Infections in Neutropenic Patients with Hematological Malignancies: A 7-Year Retrospective StudyWang SSong YShi NYin DKang JCai WDuan JShuyun Wang,1 Yan Song,1 Nan Shi,1,2 Donghong Yin,1 Jianbang Kang,1 Wanni Cai,2 Jinju Duan1 1Department of Pharmacy, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Department of Pharmacy, School of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of ChinaCorrespondence: Jinju Duan, Department of Pharmacy, Second Hospital of Shanxi Medical University, Wuyi Road, Xinghualing District, Taiyuan, Shanxi, People’s Republic of China, Tel +86 13834653172, Email duanjinju@163.comPurpose: The aim of this study was to investigate the current epidemiology, its changes during the study years, and inflammatory biomarkers of bacterial bloodstream infections (BSIs) in neutropenic patients with hematological malignancies. We assessed mortality risk factors and multidrug-resistant (MDR) gram-negative BSI predictors.Patients and Methods: We conducted a retrospective study from January 2015 to December 2021, which included adult neutropenic oncohematological patients with confirmed BSIs. We used univariable and multivariable analyses to analyze the risk factors. Each index’s reliability for bacterial BSI diagnosis was assessed using the receiver-operating characteristic curve and area under the curve.Results: A total of 514 isolates were obtained from the 452 patients. The average mortality was 17.71%. Gram-negative organisms were the predominant causes of BSI. Escherichia coli was the most common microorganism (49.90%). The overall variation trend of the isolation rate of MDR and carbapenem-resistant gram-negative bacteria increased. Multivariate analysis indicated that: 1) neutropenia that lasted for more than 7 days, patients ≥ 60 years of age, septic shock, hospitalization for > 20 days, BSI with a carbapenem-resistant strain, and treatment with linezolid or vancomycin in infections lasting less than 30 days were independent mortality risk factors; 2) severe neutropenia exceeding 7 days, unreasonable empirical therapy, and receipt of aminoglycosides or 3rd or 4th generation cephalosporins in infections lasting less than 30 days were independent risk factors of MDR gram-negative bacteria. Procalcitonin, absolute neutrophil count, and white blood cell indicate higher diagnostic accuracy for BSIs. Moreover, bacteria time to detection was better at differentiating Gram-negative and Gram-positive bacterial infections.Conclusion: We analyzed the risk factors for BSI neutropenic patients with hematological malignancies, the distribution of bacteria, antibiotic resistance, and the changes in clinical parameters. This single-center retrospective study may provide clinicians with novel insights into the diagnosis and treatment of BSI to improve future clinical outcomes.Keywords: bloodstream infection, neutropenia, hematological malignancy, pathogens distribution, antibiotic susceptibility, risk factorshttps://www.dovepress.com/characteristics-outcomes-and-clinical-indicators-of-bloodstream-infect-peer-reviewed-fulltext-article-IDRbloodstream infectionneutropeniahematological malignancypathogens distributionantibiotic susceptibilityrisk factors. |
| spellingShingle | Wang S Song Y Shi N Yin D Kang J Cai W Duan J Characteristics, Outcomes, and Clinical Indicators of Bloodstream Infections in Neutropenic Patients with Hematological Malignancies: A 7-Year Retrospective Study Infection and Drug Resistance bloodstream infection neutropenia hematological malignancy pathogens distribution antibiotic susceptibility risk factors. |
| title | Characteristics, Outcomes, and Clinical Indicators of Bloodstream Infections in Neutropenic Patients with Hematological Malignancies: A 7-Year Retrospective Study |
| title_full | Characteristics, Outcomes, and Clinical Indicators of Bloodstream Infections in Neutropenic Patients with Hematological Malignancies: A 7-Year Retrospective Study |
| title_fullStr | Characteristics, Outcomes, and Clinical Indicators of Bloodstream Infections in Neutropenic Patients with Hematological Malignancies: A 7-Year Retrospective Study |
| title_full_unstemmed | Characteristics, Outcomes, and Clinical Indicators of Bloodstream Infections in Neutropenic Patients with Hematological Malignancies: A 7-Year Retrospective Study |
| title_short | Characteristics, Outcomes, and Clinical Indicators of Bloodstream Infections in Neutropenic Patients with Hematological Malignancies: A 7-Year Retrospective Study |
| title_sort | characteristics outcomes and clinical indicators of bloodstream infections in neutropenic patients with hematological malignancies a 7 year retrospective study |
| topic | bloodstream infection neutropenia hematological malignancy pathogens distribution antibiotic susceptibility risk factors. |
| url | https://www.dovepress.com/characteristics-outcomes-and-clinical-indicators-of-bloodstream-infect-peer-reviewed-fulltext-article-IDR |
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