Bi-layered calcium phosphate cement-based composite scaffold mimicking natural bone structure
In this study, a core/shell bi-layered calcium phosphate cement (CPC)-based composite scaffold with adjustable compressive strength, which mimicked the structure of natural cortical/cancellous bone, was fabricated. The dense tubular CPC shell was prepared by isostatic pressing CPC powder with a spec...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2013-01-01
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| Series: | Science and Technology of Advanced Materials |
| Online Access: | http://dx.doi.org/10.1088/1468-6996/14/4/045010 |
| _version_ | 1818262067291881472 |
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| author | Fupo He and Jiandong Ye |
| author_facet | Fupo He and Jiandong Ye |
| author_sort | Fupo He and Jiandong Ye |
| collection | DOAJ |
| description | In this study, a core/shell bi-layered calcium phosphate cement (CPC)-based composite scaffold with adjustable compressive strength, which mimicked the structure of natural cortical/cancellous bone, was fabricated. The dense tubular CPC shell was prepared by isostatic pressing CPC powder with a specially designed mould. A porous CPC core with unidirectional lamellar pore structure was fabricated inside the cavity of dense tubular CPC shell by unidirectional freeze casting, followed by infiltration of poly(lactic-co-glycolic acid) and immobilization of collagen. The compressive strength of bi-layered CPC-based composite scaffold can be controlled by varying thickness ratio of dense layer to porous layer. Compared to the scaffold without dense shell, the pore interconnection of bi-layered scaffold was not obviously compromised because of its high unidirectional interconnectivity but poor three dimensional interconnectivity. The in vitro results showed that the rat bone marrow stromal cells attached and proliferated well on the bi-layered CPC-based composite scaffold. This novel bi-layered CPC-based composite scaffold is promising for bone repair. |
| first_indexed | 2024-12-12T18:57:14Z |
| format | Article |
| id | doaj.art-f93a3eeeb0194affacc85f8676906957 |
| institution | Directory Open Access Journal |
| issn | 1468-6996 1878-5514 |
| language | English |
| last_indexed | 2024-12-12T18:57:14Z |
| publishDate | 2013-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Science and Technology of Advanced Materials |
| spelling | doaj.art-f93a3eeeb0194affacc85f86769069572022-12-22T00:15:14ZengTaylor & Francis GroupScience and Technology of Advanced Materials1468-69961878-55142013-01-0114404501010.1088/1468-6996/14/4/045010Bi-layered calcium phosphate cement-based composite scaffold mimicking natural bone structureFupo He and Jiandong YeIn this study, a core/shell bi-layered calcium phosphate cement (CPC)-based composite scaffold with adjustable compressive strength, which mimicked the structure of natural cortical/cancellous bone, was fabricated. The dense tubular CPC shell was prepared by isostatic pressing CPC powder with a specially designed mould. A porous CPC core with unidirectional lamellar pore structure was fabricated inside the cavity of dense tubular CPC shell by unidirectional freeze casting, followed by infiltration of poly(lactic-co-glycolic acid) and immobilization of collagen. The compressive strength of bi-layered CPC-based composite scaffold can be controlled by varying thickness ratio of dense layer to porous layer. Compared to the scaffold without dense shell, the pore interconnection of bi-layered scaffold was not obviously compromised because of its high unidirectional interconnectivity but poor three dimensional interconnectivity. The in vitro results showed that the rat bone marrow stromal cells attached and proliferated well on the bi-layered CPC-based composite scaffold. This novel bi-layered CPC-based composite scaffold is promising for bone repair.http://dx.doi.org/10.1088/1468-6996/14/4/045010 |
| spellingShingle | Fupo He and Jiandong Ye Bi-layered calcium phosphate cement-based composite scaffold mimicking natural bone structure Science and Technology of Advanced Materials |
| title | Bi-layered calcium phosphate cement-based composite scaffold mimicking natural bone structure |
| title_full | Bi-layered calcium phosphate cement-based composite scaffold mimicking natural bone structure |
| title_fullStr | Bi-layered calcium phosphate cement-based composite scaffold mimicking natural bone structure |
| title_full_unstemmed | Bi-layered calcium phosphate cement-based composite scaffold mimicking natural bone structure |
| title_short | Bi-layered calcium phosphate cement-based composite scaffold mimicking natural bone structure |
| title_sort | bi layered calcium phosphate cement based composite scaffold mimicking natural bone structure |
| url | http://dx.doi.org/10.1088/1468-6996/14/4/045010 |
| work_keys_str_mv | AT fupoheandjiandongye bilayeredcalciumphosphatecementbasedcompositescaffoldmimickingnaturalbonestructure |