Predicting type 2 diabetes mellitus: a comparison between the FINDRISC score and the metabolic syndrome
Abstract Background The aim of this study to compare the diagnostic accuracy of the metabolic syndrome (MetS) with the FINDRISC score to screen for type 2 diabetes mellitus T2DM in an overweight/obese population. Methods Subjects 18 years or older visiting the obesity clinic of the Antwerp Universit...
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| Format: | Article |
| Language: | English |
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BMC
2018-03-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13098-018-0310-0 |
| _version_ | 1819116001819623424 |
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| author | Abraham S. Meijnikman Christophe E. M. De Block An Verrijken Ilse Mertens Luc F. Van Gaal |
| author_facet | Abraham S. Meijnikman Christophe E. M. De Block An Verrijken Ilse Mertens Luc F. Van Gaal |
| author_sort | Abraham S. Meijnikman |
| collection | DOAJ |
| description | Abstract Background The aim of this study to compare the diagnostic accuracy of the metabolic syndrome (MetS) with the FINDRISC score to screen for type 2 diabetes mellitus T2DM in an overweight/obese population. Methods Subjects 18 years or older visiting the obesity clinic of the Antwerp University Hospital were consecutively recruited between 2012 and 2014. Every patient underwent a standard metabolic work-up including a clinical examination with anthropometry. Glucose status was tested using OGTT and Hba1c. FINDRISC questionnaire and MetS were examined. Results Of 651 subjects, 50.4% were diagnosed with prediabetes, whereas 11.1% was diagnosed with T2DM. FINDRISC score increased with worsening of glucose status 11 ± 3, 13 ± 4 and 15 ± 5 in respectively, subjects without T2DM, prediabetes and T2DM. 312 subjects had the MetS. The aROC of the FINDRISC to identify subjects with T2DM was 0.76 (95% CI 0.72–0.82), sensitivity was 64% and specificity was 63% with 13 as cutoff point. Adding FPG or HbA1c to FINDRISC, the aROC increased significantly to 0.91(95% CI 0.88–0.95) and 0.93(95% CI 0.90–0.97), respectively (p < 0.001). The aROC of the MetS to identify subjects with diabetes was 0.72 (95% CI 0.65–0.78), sensitivity was 75% and specificity was 55%. The aROC of the FINDRISC + HbA1c was significantly higher than the MetS for predicting T2DM (p < 0.001). Conclusion Prediction of type 2 diabetes is important for timely intervention and to avoid chronic complications associated with the disease. Our findings suggest, that it may be of good clinical practice to use the FINDRISC score + HbA1c in a two-step screening model for diabetes rather than using the metabolic syndrome. |
| first_indexed | 2024-12-22T05:10:09Z |
| format | Article |
| id | doaj.art-f93a50b7761a4f46a30d42512a7c89e6 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-12-22T05:10:09Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-f93a50b7761a4f46a30d42512a7c89e62022-12-21T18:38:00ZengBMCDiabetology & Metabolic Syndrome1758-59962018-03-011011610.1186/s13098-018-0310-0Predicting type 2 diabetes mellitus: a comparison between the FINDRISC score and the metabolic syndromeAbraham S. Meijnikman0Christophe E. M. De Block1An Verrijken2Ilse Mertens3Luc F. Van Gaal4Department of Endocrinology, Diabetology & Metabolism, Faculty of Medicine, Antwerp University Hospital and University of AntwerpDepartment of Endocrinology, Diabetology & Metabolism, Faculty of Medicine, Antwerp University Hospital and University of AntwerpDepartment of Endocrinology, Diabetology & Metabolism, Faculty of Medicine, Antwerp University Hospital and University of AntwerpDepartment of Endocrinology, Diabetology & Metabolism, Faculty of Medicine, Antwerp University Hospital and University of AntwerpDepartment of Endocrinology, Diabetology & Metabolism, Faculty of Medicine, Antwerp University Hospital and University of AntwerpAbstract Background The aim of this study to compare the diagnostic accuracy of the metabolic syndrome (MetS) with the FINDRISC score to screen for type 2 diabetes mellitus T2DM in an overweight/obese population. Methods Subjects 18 years or older visiting the obesity clinic of the Antwerp University Hospital were consecutively recruited between 2012 and 2014. Every patient underwent a standard metabolic work-up including a clinical examination with anthropometry. Glucose status was tested using OGTT and Hba1c. FINDRISC questionnaire and MetS were examined. Results Of 651 subjects, 50.4% were diagnosed with prediabetes, whereas 11.1% was diagnosed with T2DM. FINDRISC score increased with worsening of glucose status 11 ± 3, 13 ± 4 and 15 ± 5 in respectively, subjects without T2DM, prediabetes and T2DM. 312 subjects had the MetS. The aROC of the FINDRISC to identify subjects with T2DM was 0.76 (95% CI 0.72–0.82), sensitivity was 64% and specificity was 63% with 13 as cutoff point. Adding FPG or HbA1c to FINDRISC, the aROC increased significantly to 0.91(95% CI 0.88–0.95) and 0.93(95% CI 0.90–0.97), respectively (p < 0.001). The aROC of the MetS to identify subjects with diabetes was 0.72 (95% CI 0.65–0.78), sensitivity was 75% and specificity was 55%. The aROC of the FINDRISC + HbA1c was significantly higher than the MetS for predicting T2DM (p < 0.001). Conclusion Prediction of type 2 diabetes is important for timely intervention and to avoid chronic complications associated with the disease. Our findings suggest, that it may be of good clinical practice to use the FINDRISC score + HbA1c in a two-step screening model for diabetes rather than using the metabolic syndrome.http://link.springer.com/article/10.1186/s13098-018-0310-0Type 2 diabetes mellitusPrediabetesScreeningMetabolic syndromeFINDRISCObesity |
| spellingShingle | Abraham S. Meijnikman Christophe E. M. De Block An Verrijken Ilse Mertens Luc F. Van Gaal Predicting type 2 diabetes mellitus: a comparison between the FINDRISC score and the metabolic syndrome Diabetology & Metabolic Syndrome Type 2 diabetes mellitus Prediabetes Screening Metabolic syndrome FINDRISC Obesity |
| title | Predicting type 2 diabetes mellitus: a comparison between the FINDRISC score and the metabolic syndrome |
| title_full | Predicting type 2 diabetes mellitus: a comparison between the FINDRISC score and the metabolic syndrome |
| title_fullStr | Predicting type 2 diabetes mellitus: a comparison between the FINDRISC score and the metabolic syndrome |
| title_full_unstemmed | Predicting type 2 diabetes mellitus: a comparison between the FINDRISC score and the metabolic syndrome |
| title_short | Predicting type 2 diabetes mellitus: a comparison between the FINDRISC score and the metabolic syndrome |
| title_sort | predicting type 2 diabetes mellitus a comparison between the findrisc score and the metabolic syndrome |
| topic | Type 2 diabetes mellitus Prediabetes Screening Metabolic syndrome FINDRISC Obesity |
| url | http://link.springer.com/article/10.1186/s13098-018-0310-0 |
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