Genomic landscape of the immunogenicity regulation in skin melanomas with diverse tumor mutation burden

Genomic landscape of the immunogenicity regulation in skin melanomas with diverse tumor mutation burden

Skin melanoma cells are tightly interconnected with their tumor microenvironment (TME), which influences their initiation, progression, and sensitivity/resistance to therapeutic interventions. An immune-active TME favors patient response to immune checkpoint inhibition (ICI), but not all patients re...

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Bibliographic Details
Main Authors: George Georgoulias, Apostolos Zaravinos
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
skin melanoma
tumor mutation burden (TMB)
immune signatures
immune checkpoint inhibition therapy
patient response
tumor-infiltrating lymphocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1006665/full

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