Using AlphaFold to predict the impact of single mutations on protein stability and function.

Using AlphaFold to predict the impact of single mutations on protein stability and function.

AlphaFold changed the field of structural biology by achieving three-dimensional (3D) structure prediction from protein sequence at experimental quality. The astounding success even led to claims that the protein folding problem is "solved". However, protein folding problem is more than ju...

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Bibliographic Details
Main Authors: Marina A Pak, Karina A Markhieva, Mariia S Novikova, Dmitry S Petrov, Ilya S Vorobyev, Ekaterina S Maksimova, Fyodor A Kondrashov, Dmitry N Ivankov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0282689

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