Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset
Behçet disease (BD) is a multisystemic disease that commonly involves the eyes. Although it affects patients in all age groups, data on ocular disease by age of onset are limited. This retrospective, multicenter study aimed to compare epidemiology, systemic and ocular manifestations, treatments and...
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| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/2/624 |
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| author | Michael Ostrovsky Amir Rosenblatt Salam Iriqat Abdallah Shteiwi Yael Sharon Michal Kramer Vicktoria Vishnevskia-Dai Shaul Sar Yosif Boulos Oren Tomkins-Netzer Natalie Lavee Yael Ben-Arie-Weintrob Hadas Pizem Tamar Hareuveni-Blum Marina Schneck Raz Gepstein Dua Masarwa Nakhoul Nakhoul Erez Bakshi Shiri Shulman Michaella Goldstein Dan Ramon Marina Anouk Zohar Habot-Wilner |
| author_facet | Michael Ostrovsky Amir Rosenblatt Salam Iriqat Abdallah Shteiwi Yael Sharon Michal Kramer Vicktoria Vishnevskia-Dai Shaul Sar Yosif Boulos Oren Tomkins-Netzer Natalie Lavee Yael Ben-Arie-Weintrob Hadas Pizem Tamar Hareuveni-Blum Marina Schneck Raz Gepstein Dua Masarwa Nakhoul Nakhoul Erez Bakshi Shiri Shulman Michaella Goldstein Dan Ramon Marina Anouk Zohar Habot-Wilner |
| author_sort | Michael Ostrovsky |
| collection | DOAJ |
| description | Behçet disease (BD) is a multisystemic disease that commonly involves the eyes. Although it affects patients in all age groups, data on ocular disease by age of onset are limited. This retrospective, multicenter study aimed to compare epidemiology, systemic and ocular manifestations, treatments and outcomes between three age groups: juvenile (<18 years), adult (18–39 years) and late (≥40 years) disease onset. The study included 175 ocular BD patients (303 eyes) from Israel and Palestine: juvenile-onset (<i>n</i> = 25, 14.3%), adult-onset (<i>n</i> = 120, 68.6%) and late-onset (<i>n</i> = 30, 17.1%). Most patients in all groups were male. Systemic manifestations were similar in all groups. Systemic co-morbidities were more common in late-onset patients. Bilateral panuveitis was the most common ocular manifestation in all patients. Non-occlusive retinal vasculitis, peripheral vessel occlusions, cataract and elevated intraocular pressure were found more commonly among juvenile-onset eyes. Anterior uveitis and macular ischemia were most common among late-onset eyes, while branch retinal vein occlusion was most common in adult and late-onset eyes. All patients were treated with corticosteroids. Methotrexate, immunomodulatory combinations and biologic treatments were more commonly used for juvenile-onset patients. All groups had a similar visual outcome. Our study showed that patients with ocular BD have varied ocular manifestations and require different treatments according to age of disease onset, but visual outcome is similar. |
| first_indexed | 2024-03-11T09:06:31Z |
| format | Article |
| id | doaj.art-f93da6fa7ce14fba9e219bf8cb2066ab |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T09:06:31Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-f93da6fa7ce14fba9e219bf8cb2066ab2023-11-16T19:21:00ZengMDPI AGBiomedicines2227-90592023-02-0111262410.3390/biomedicines11020624Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease OnsetMichael Ostrovsky0Amir Rosenblatt1Salam Iriqat2Abdallah Shteiwi3Yael Sharon4Michal Kramer5Vicktoria Vishnevskia-Dai6Shaul Sar7Yosif Boulos8Oren Tomkins-Netzer9Natalie Lavee10Yael Ben-Arie-Weintrob11Hadas Pizem12Tamar Hareuveni-Blum13Marina Schneck14Raz Gepstein15Dua Masarwa16Nakhoul Nakhoul17Erez Bakshi18Shiri Shulman19Michaella Goldstein20Dan Ramon21Marina Anouk22Zohar Habot-Wilner23Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelSt. John of Jerusalem Eye Hospital Group, East Jerusalem 91198, PalestineSt. John of Jerusalem Eye Hospital Group, East Jerusalem 91198, PalestineSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelDepartment of Ophthalmology, Carmel Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 3436212, IsraelDepartment of Ophthalmology, Carmel Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 3436212, IsraelDepartment of Ophthalmology, Carmel Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 3436212, IsraelDepartment of Ophthalmology, HaEmek Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 183411, IsraelDepartment of Ophthalmology, Rambam Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 3525408, IsraelDepartment of Ophthalmology, Rambam Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 3525408, IsraelDepartment of Ophthalmology, Galilee Medical Center, Azrieli Faculty of Medicine, Bar-Ilan University, Galilee 22100, IsraelDepartment of Ophthalmology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 84101, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelDepartment of Ophthalmology, Barzilai Medical Center, Ashkelon, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheba 7830604, IsraelDepartment of Ophthalmology, Baruch Padeh Medical Center, Azrieli Faculty of Medicine, Bar-Ilan University, Galilee 15280, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelOphthalmology institute, Assuta Medical Centers, Tel Aviv 6789140, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelBehçet disease (BD) is a multisystemic disease that commonly involves the eyes. Although it affects patients in all age groups, data on ocular disease by age of onset are limited. This retrospective, multicenter study aimed to compare epidemiology, systemic and ocular manifestations, treatments and outcomes between three age groups: juvenile (<18 years), adult (18–39 years) and late (≥40 years) disease onset. The study included 175 ocular BD patients (303 eyes) from Israel and Palestine: juvenile-onset (<i>n</i> = 25, 14.3%), adult-onset (<i>n</i> = 120, 68.6%) and late-onset (<i>n</i> = 30, 17.1%). Most patients in all groups were male. Systemic manifestations were similar in all groups. Systemic co-morbidities were more common in late-onset patients. Bilateral panuveitis was the most common ocular manifestation in all patients. Non-occlusive retinal vasculitis, peripheral vessel occlusions, cataract and elevated intraocular pressure were found more commonly among juvenile-onset eyes. Anterior uveitis and macular ischemia were most common among late-onset eyes, while branch retinal vein occlusion was most common in adult and late-onset eyes. All patients were treated with corticosteroids. Methotrexate, immunomodulatory combinations and biologic treatments were more commonly used for juvenile-onset patients. All groups had a similar visual outcome. Our study showed that patients with ocular BD have varied ocular manifestations and require different treatments according to age of disease onset, but visual outcome is similar.https://www.mdpi.com/2227-9059/11/2/624Behçet diseaseocular Behçet diseasejuvenile-onset Behçet diseaseadult-onset Behçet diseaselate-onset Behçet diseaseBehçet uveitis |
| spellingShingle | Michael Ostrovsky Amir Rosenblatt Salam Iriqat Abdallah Shteiwi Yael Sharon Michal Kramer Vicktoria Vishnevskia-Dai Shaul Sar Yosif Boulos Oren Tomkins-Netzer Natalie Lavee Yael Ben-Arie-Weintrob Hadas Pizem Tamar Hareuveni-Blum Marina Schneck Raz Gepstein Dua Masarwa Nakhoul Nakhoul Erez Bakshi Shiri Shulman Michaella Goldstein Dan Ramon Marina Anouk Zohar Habot-Wilner Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset Biomedicines Behçet disease ocular Behçet disease juvenile-onset Behçet disease adult-onset Behçet disease late-onset Behçet disease Behçet uveitis |
| title | Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset |
| title_full | Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset |
| title_fullStr | Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset |
| title_full_unstemmed | Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset |
| title_short | Ocular Behçet Disease—Clinical Manifestations, Treatments and Outcomes According to Age at Disease Onset |
| title_sort | ocular behcet disease clinical manifestations treatments and outcomes according to age at disease onset |
| topic | Behçet disease ocular Behçet disease juvenile-onset Behçet disease adult-onset Behçet disease late-onset Behçet disease Behçet uveitis |
| url | https://www.mdpi.com/2227-9059/11/2/624 |
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