Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus
Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry a...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-01-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/11/1/49 |
| _version_ | 1818118491514863616 |
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| author | Mariana N. Batista Ana Cláudia S. Braga Guilherme Rodrigues Fernandes Campos Marcos Michel Souza Renata Prandini Adum de Matos Tairine Zara Lopes Natalia Maria Candido Maria Leticia Duarte Lima Francielly Cristina Machado Stephane Tereza Queiroz de Andrade Cíntia Bittar Maurício L. Nogueira Bruno M. Carneiro Ricardo B. Mariutti Raghuvir Krishnaswamy Arni Marilia Freitas Calmon Paula Rahal |
| author_facet | Mariana N. Batista Ana Cláudia S. Braga Guilherme Rodrigues Fernandes Campos Marcos Michel Souza Renata Prandini Adum de Matos Tairine Zara Lopes Natalia Maria Candido Maria Leticia Duarte Lima Francielly Cristina Machado Stephane Tereza Queiroz de Andrade Cíntia Bittar Maurício L. Nogueira Bruno M. Carneiro Ricardo B. Mariutti Raghuvir Krishnaswamy Arni Marilia Freitas Calmon Paula Rahal |
| author_sort | Mariana N. Batista |
| collection | DOAJ |
| description | Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of several viruses. We show that emodin and berberine trigger a virucidal effect on ZIKV. When the virus was exposed to 160 µM of berberine, a reduction of 77.6% in the infectivity was observed; when emodin was used (40 µM), this reduction was approximately 83.3%. Dynamic light scattering data showed that both compounds significantly reduce the hydrodynamic radius of virus particle in solution. We report here that berberine and emodin, two natural compounds, have strong virucidal effect in Zika virus. |
| first_indexed | 2024-12-11T04:55:09Z |
| format | Article |
| id | doaj.art-f93e02228dba4de184df69f9547e763e |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-11T04:55:09Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-f93e02228dba4de184df69f9547e763e2022-12-22T01:20:18ZengMDPI AGViruses1999-49152019-01-011114910.3390/v11010049v11010049Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika VirusMariana N. Batista0Ana Cláudia S. Braga1Guilherme Rodrigues Fernandes Campos2Marcos Michel Souza3Renata Prandini Adum de Matos4Tairine Zara Lopes5Natalia Maria Candido6Maria Leticia Duarte Lima7Francielly Cristina Machado8Stephane Tereza Queiroz de Andrade9Cíntia Bittar10Maurício L. Nogueira11Bruno M. Carneiro12Ricardo B. Mariutti13Raghuvir Krishnaswamy Arni14Marilia Freitas Calmon15Paula Rahal16Laboratory of Genomic Studies, Sao Paulo State University—UNESP, São José do Rio Preto 15054-000, São Paulo, BrazilLaboratory of Genomic Studies, Sao Paulo State University—UNESP, São José do Rio Preto 15054-000, São Paulo, BrazilLaboratory of Genomic Studies, Sao Paulo State University—UNESP, São José do Rio Preto 15054-000, São Paulo, BrazilLaboratory of Genomic Studies, Sao Paulo State University—UNESP, São José do Rio Preto 15054-000, São Paulo, BrazilLaboratory of Genomic Studies, Sao Paulo State University—UNESP, São José do Rio Preto 15054-000, São Paulo, BrazilLaboratory of Genomic Studies, Sao Paulo State University—UNESP, São José do Rio Preto 15054-000, São Paulo, BrazilLaboratory of Genomic Studies, Sao Paulo State University—UNESP, São José do Rio Preto 15054-000, São Paulo, BrazilLaboratory of Genomic Studies, Sao Paulo State University—UNESP, São José do Rio Preto 15054-000, São Paulo, BrazilLaboratory of Genomic Studies, Sao Paulo State University—UNESP, São José do Rio Preto 15054-000, São Paulo, BrazilLaboratory of Genomic Studies, Sao Paulo State University—UNESP, São José do Rio Preto 15054-000, São Paulo, BrazilLaboratory of Genomic Studies, Sao Paulo State University—UNESP, São José do Rio Preto 15054-000, São Paulo, BrazilDepartamento de Doenças Infecciosas e Parasitárias, FAMERP, São José do Rio Preto 15090-000, São Paulo, BrazilLaboratory of Genomic Studies, Sao Paulo State University—UNESP, São José do Rio Preto 15054-000, São Paulo, BrazilDepartment of Physics, Multiuser Center for Biomolecular Innovation, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil;<email>ricardomariutti@yahoo.com.br</email> (R.B.M.)Department of Physics, Multiuser Center for Biomolecular Innovation, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil;<email>ricardomariutti@yahoo.com.br</email> (R.B.M.)Laboratory of Genomic Studies, Sao Paulo State University—UNESP, São José do Rio Preto 15054-000, São Paulo, BrazilLaboratory of Genomic Studies, Sao Paulo State University—UNESP, São José do Rio Preto 15054-000, São Paulo, BrazilZika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of several viruses. We show that emodin and berberine trigger a virucidal effect on ZIKV. When the virus was exposed to 160 µM of berberine, a reduction of 77.6% in the infectivity was observed; when emodin was used (40 µM), this reduction was approximately 83.3%. Dynamic light scattering data showed that both compounds significantly reduce the hydrodynamic radius of virus particle in solution. We report here that berberine and emodin, two natural compounds, have strong virucidal effect in Zika virus.http://www.mdpi.com/1999-4915/11/1/49ZIKVberberinemodinVero E6 cells |
| spellingShingle | Mariana N. Batista Ana Cláudia S. Braga Guilherme Rodrigues Fernandes Campos Marcos Michel Souza Renata Prandini Adum de Matos Tairine Zara Lopes Natalia Maria Candido Maria Leticia Duarte Lima Francielly Cristina Machado Stephane Tereza Queiroz de Andrade Cíntia Bittar Maurício L. Nogueira Bruno M. Carneiro Ricardo B. Mariutti Raghuvir Krishnaswamy Arni Marilia Freitas Calmon Paula Rahal Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus Viruses ZIKV berberin emodin Vero E6 cells |
| title | Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus |
| title_full | Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus |
| title_fullStr | Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus |
| title_full_unstemmed | Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus |
| title_short | Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus |
| title_sort | natural products isolated from oriental medicinal herbs inactivate zika virus |
| topic | ZIKV berberin emodin Vero E6 cells |
| url | http://www.mdpi.com/1999-4915/11/1/49 |
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