Case–Control Study of Long COVID, Sapporo, Japan
We conducted a cross-sectional survey among SARS-CoV-2–positive persons and negative controls in Sapporo, Japan, to clarify symptoms of long COVID. We collected responses from 8,018 participants, 3,694 case-patients and 3,672 controls. We calculated symptom prevalence for case-patients at 2–3, 4–6,...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2023-05-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/29/5/22-1349_article |
| _version_ | 1797843481142493184 |
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| author | Toshiaki Asakura Takashi Kimura Isaku Kurotori Katabami Kenichi Miyuki Hori Mariko Hosogawa Masayuki Saijo Kaori Nakanishi Hiroyasu Iso Akiko Tamakoshi |
| author_facet | Toshiaki Asakura Takashi Kimura Isaku Kurotori Katabami Kenichi Miyuki Hori Mariko Hosogawa Masayuki Saijo Kaori Nakanishi Hiroyasu Iso Akiko Tamakoshi |
| author_sort | Toshiaki Asakura |
| collection | DOAJ |
| description |
We conducted a cross-sectional survey among SARS-CoV-2–positive persons and negative controls in Sapporo, Japan, to clarify symptoms of long COVID. We collected responses from 8,018 participants, 3,694 case-patients and 3,672 controls. We calculated symptom prevalence for case-patients at 2–3, 4–6, 7–9, 10–12, and 13–18 months after illness onset. We used logistic regression, adjusted for age and sex, to estimate the odds ratio (OR) for each symptom and control reference. We calculated symptom prevalence by stratifying for disease severity, age, and sex. At 4–18 months from illness onset, ORs for anosmia, ageusia, dyspnea, alopecia, and brain fog were consistently >1, whereas ORs for common cold–like, gastrointestinal, and dermatologic symptoms were <1. Time trend ORs increased for diminished ability to concentrate, brain fog, sleep disturbance, eye symptoms, and tinnitus. Clinicians should focus on systemic, respiratory, and neuropsychiatric symptoms among long COVID patients.
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| first_indexed | 2024-04-09T17:07:00Z |
| format | Article |
| id | doaj.art-f94031d2f3c349738a62dbee0f73b71a |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-09T17:07:00Z |
| publishDate | 2023-05-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-f94031d2f3c349738a62dbee0f73b71a2023-04-20T14:27:38ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592023-05-0129595696610.3201/eid2905.221349Case–Control Study of Long COVID, Sapporo, JapanToshiaki AsakuraTakashi KimuraIsaku KurotoriKatabami KenichiMiyuki HoriMariko HosogawaMasayuki SaijoKaori NakanishiHiroyasu IsoAkiko Tamakoshi We conducted a cross-sectional survey among SARS-CoV-2–positive persons and negative controls in Sapporo, Japan, to clarify symptoms of long COVID. We collected responses from 8,018 participants, 3,694 case-patients and 3,672 controls. We calculated symptom prevalence for case-patients at 2–3, 4–6, 7–9, 10–12, and 13–18 months after illness onset. We used logistic regression, adjusted for age and sex, to estimate the odds ratio (OR) for each symptom and control reference. We calculated symptom prevalence by stratifying for disease severity, age, and sex. At 4–18 months from illness onset, ORs for anosmia, ageusia, dyspnea, alopecia, and brain fog were consistently >1, whereas ORs for common cold–like, gastrointestinal, and dermatologic symptoms were <1. Time trend ORs increased for diminished ability to concentrate, brain fog, sleep disturbance, eye symptoms, and tinnitus. Clinicians should focus on systemic, respiratory, and neuropsychiatric symptoms among long COVID patients. https://wwwnc.cdc.gov/eid/article/29/5/22-1349_articleCOVID-19respiratory infectionssevere acute respiratory syndrome coronavirus 2SARS-CoV-2SARScoronavirus disease |
| spellingShingle | Toshiaki Asakura Takashi Kimura Isaku Kurotori Katabami Kenichi Miyuki Hori Mariko Hosogawa Masayuki Saijo Kaori Nakanishi Hiroyasu Iso Akiko Tamakoshi Case–Control Study of Long COVID, Sapporo, Japan Emerging Infectious Diseases COVID-19 respiratory infections severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 SARS coronavirus disease |
| title | Case–Control Study of Long COVID, Sapporo, Japan |
| title_full | Case–Control Study of Long COVID, Sapporo, Japan |
| title_fullStr | Case–Control Study of Long COVID, Sapporo, Japan |
| title_full_unstemmed | Case–Control Study of Long COVID, Sapporo, Japan |
| title_short | Case–Control Study of Long COVID, Sapporo, Japan |
| title_sort | case control study of long covid sapporo japan |
| topic | COVID-19 respiratory infections severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 SARS coronavirus disease |
| url | https://wwwnc.cdc.gov/eid/article/29/5/22-1349_article |
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