Emerging Biosensors for Oral Cancer Detection and Diagnosis—A Review Unravelling Their Role in Past and Present Advancements in the Field of Early Diagnosis
Oral cancer is a serious concern to people all over the world because of its high mortality rate and metastatic spread to other areas of the body. Despite recent advancements in biomedical research, OC detection at an early stage remains a challenge and is complex and inaccurate with conventional di...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/12/7/498 |
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| author | Vidhya Rekha Umapathy Prabhu Manickam Natarajan Bhuminathan Swamikannu Johnson Moses Sumathi Jones Manoj Prathap Chandran Madurai Kannan Anbumozhi |
| author_facet | Vidhya Rekha Umapathy Prabhu Manickam Natarajan Bhuminathan Swamikannu Johnson Moses Sumathi Jones Manoj Prathap Chandran Madurai Kannan Anbumozhi |
| author_sort | Vidhya Rekha Umapathy |
| collection | DOAJ |
| description | Oral cancer is a serious concern to people all over the world because of its high mortality rate and metastatic spread to other areas of the body. Despite recent advancements in biomedical research, OC detection at an early stage remains a challenge and is complex and inaccurate with conventional diagnostics procedures. It is critical to study innovative approaches that can enable a faster, easier, non-invasive, and more precise diagnosis of OC in order to increase the survival rate of patients. In this paper, we conducted a review on how biosensors might be an excellent tool for detecting OC. This review covers the strategies that use different biosensors to target various types of biomarkers and focuses on biosensors that function at the molecular level viz. DNA biosensors, RNA biosensors, and protein biosensors. In addition, we reviewed non-invasive electrochemical methods, optical methods, and nano biosensors to analyze the OC biomarkers present in body fluids such as saliva and serum. As a result, this review sheds light on the development of ground-breaking biosensors for the early detection and diagnosis of OC. |
| first_indexed | 2024-03-09T03:38:59Z |
| format | Article |
| id | doaj.art-f941ae33c33f4d378b80e0d9a3c4d8c5 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T03:38:59Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-f941ae33c33f4d378b80e0d9a3c4d8c52023-12-03T14:44:16ZengMDPI AGBiosensors2079-63742022-07-0112749810.3390/bios12070498Emerging Biosensors for Oral Cancer Detection and Diagnosis—A Review Unravelling Their Role in Past and Present Advancements in the Field of Early DiagnosisVidhya Rekha Umapathy0Prabhu Manickam Natarajan1Bhuminathan Swamikannu2Johnson Moses3Sumathi Jones4Manoj Prathap Chandran5Madurai Kannan Anbumozhi6Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai 600 100, IndiaDepartment of Periodontics, College of Dentistry, Ajman University, Ajman P.O. Box 346, United Arab EmiratesDepartment of Prosthodontics, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai 600 100, IndiaDepartment of Anatomy, Sree Balaji Medical College and Hospital, Chromepet, Chennai 600 044, IndiaDepartment of Pharmacology, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai 600 100, IndiaJunior Research Fellow, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai 600 100, IndiaDepartment of Pathology, Sree Balaji Medical College and Hospital, Chromepet, Chennai 600 044, IndiaOral cancer is a serious concern to people all over the world because of its high mortality rate and metastatic spread to other areas of the body. Despite recent advancements in biomedical research, OC detection at an early stage remains a challenge and is complex and inaccurate with conventional diagnostics procedures. It is critical to study innovative approaches that can enable a faster, easier, non-invasive, and more precise diagnosis of OC in order to increase the survival rate of patients. In this paper, we conducted a review on how biosensors might be an excellent tool for detecting OC. This review covers the strategies that use different biosensors to target various types of biomarkers and focuses on biosensors that function at the molecular level viz. DNA biosensors, RNA biosensors, and protein biosensors. In addition, we reviewed non-invasive electrochemical methods, optical methods, and nano biosensors to analyze the OC biomarkers present in body fluids such as saliva and serum. As a result, this review sheds light on the development of ground-breaking biosensors for the early detection and diagnosis of OC.https://www.mdpi.com/2079-6374/12/7/498biosensorsoral cancerbiomarkerssalivaelectrochemical biosensoroptical biosensor |
| spellingShingle | Vidhya Rekha Umapathy Prabhu Manickam Natarajan Bhuminathan Swamikannu Johnson Moses Sumathi Jones Manoj Prathap Chandran Madurai Kannan Anbumozhi Emerging Biosensors for Oral Cancer Detection and Diagnosis—A Review Unravelling Their Role in Past and Present Advancements in the Field of Early Diagnosis Biosensors biosensors oral cancer biomarkers saliva electrochemical biosensor optical biosensor |
| title | Emerging Biosensors for Oral Cancer Detection and Diagnosis—A Review Unravelling Their Role in Past and Present Advancements in the Field of Early Diagnosis |
| title_full | Emerging Biosensors for Oral Cancer Detection and Diagnosis—A Review Unravelling Their Role in Past and Present Advancements in the Field of Early Diagnosis |
| title_fullStr | Emerging Biosensors for Oral Cancer Detection and Diagnosis—A Review Unravelling Their Role in Past and Present Advancements in the Field of Early Diagnosis |
| title_full_unstemmed | Emerging Biosensors for Oral Cancer Detection and Diagnosis—A Review Unravelling Their Role in Past and Present Advancements in the Field of Early Diagnosis |
| title_short | Emerging Biosensors for Oral Cancer Detection and Diagnosis—A Review Unravelling Their Role in Past and Present Advancements in the Field of Early Diagnosis |
| title_sort | emerging biosensors for oral cancer detection and diagnosis a review unravelling their role in past and present advancements in the field of early diagnosis |
| topic | biosensors oral cancer biomarkers saliva electrochemical biosensor optical biosensor |
| url | https://www.mdpi.com/2079-6374/12/7/498 |
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