A New Serum Macrophage Checkpoint Biomarker for Innate Immunotherapy: Soluble Signal-Regulatory Protein Alpha (sSIRPα)

A New Serum Macrophage Checkpoint Biomarker for Innate Immunotherapy: Soluble Signal-Regulatory Protein Alpha (sSIRPα)

<b>Background and Aims:</b> The macrophage “don’t eat me” pathway CD47/SIRPα is a target for promising new immunotherapy. We hypothesized that a soluble variant of SIRPα is present in the blood and may function as a biomarker. <b>Methods:</b> Monocyte derived macrophages (MDM...

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Bibliographic Details
Main Authors: Yoanna V. Vladimirova, Marie K. Mølmer, Kristian W. Antonsen, Niels Møller, Nikolaj Rittig, Marlene C. Nielsen, Holger J. Møller
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomolecules
Subjects:
macrophage
immunotherapy
biomarker
SIRPα
CD47
checkpoint
Online Access:https://www.mdpi.com/2218-273X/12/7/937

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