Characterization of the poly-T variant in the TOMM40 gene in diverse populations.

Characterization of the poly-T variant in the TOMM40 gene in diverse populations.

We previously discovered that a polymorphic, deoxythymidine-homopolymer (poly-T, rs10524523) in intron 6 of the TOMM40 gene is associated with age-of-onset of Alzheimer's disease and with cognitive performance in elderly. Three allele groups were defined for rs10524523, hereafter '523'...

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Main Authors: Colton Linnertz, Ann M Saunders, Michael W Lutz, Donna M Crenshaw, Iris Grossman, Daniel K Burns, Keith E Whitfield, Michael A Hauser, Jeanette J McCarthy, Megan Ulmer, Rand Allingham, Kathleen A Welsh-Bohmer, Allen D Roses, Ornit Chiba-Falek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3281049?pdf=render

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