Advanced ImageJ Analysis in Degenerative Acquired Vitelliform Lesions Using Techniques Based on Optical Coherence Tomography
Acquired vitelliform lesions (AVLs) are associated with a large spectrum of retinal diseases, among which is age-related macular degeneration (AMD). The purpose of this study was to characterize AVLs’ evolution in AMD patients using optical coherence tomography (OCT) technology and ImageJ software....
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MDPI AG
2023-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/5/1382 |
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| author | Ioana Damian George-Adrian Muntean Larisa-Bianca Galea-Holhoș Simona-Delia Nicoară |
| author_facet | Ioana Damian George-Adrian Muntean Larisa-Bianca Galea-Holhoș Simona-Delia Nicoară |
| author_sort | Ioana Damian |
| collection | DOAJ |
| description | Acquired vitelliform lesions (AVLs) are associated with a large spectrum of retinal diseases, among which is age-related macular degeneration (AMD). The purpose of this study was to characterize AVLs’ evolution in AMD patients using optical coherence tomography (OCT) technology and ImageJ software. We measured AVLs’ size and density and followed their impacts over surrounding retinal layers. Average retinal pigment epithelium (RPE) thickness in the central 1 mm quadrant (45.89 ± 27.84 µm vs. 15.57 ± 1.40 µm) was significantly increased, as opposed to the outer nuclear layer (ONL) thickness, which was decreased (77.94 ± 18.30 µm vs. 88.64 ± 7.65 µm) in the vitelliform group compared to the control group. We found a continuous external limiting membrane (ELM) in 55.5% of the eyes compared to a continuous ellipsoid zone (EZ) in 22.2% of the eyes in the vitelliform group. The difference between the mean AVLs’ volume at baseline compared to the last visit for the nine eyes with ophthalmologic follow-up was not statistically significant (<i>p</i> = 0.725). The median follow-up duration was 11 months (range 5–56 months). Seven eyes (43.75%) were treated with intravitreal anti-vascular endothelium growth factor (anti-VEGF) agent injections, in which we noted a 6.43 ± 9 letter decrease in the best-corrected visual acuity (BCVA). The increased RPE thickness could suggest hyperplasia contrary to the decreased ONL, which could mirror the impact of the vitelliform lesion on photoreceptors (PR). Eyes that received anti-VEGF injections did not show signs of improvement regarding BCVA. |
| first_indexed | 2024-03-11T03:55:17Z |
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| language | English |
| last_indexed | 2024-03-11T03:55:17Z |
| publishDate | 2023-05-01 |
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| series | Biomedicines |
| spelling | doaj.art-f9438beb6f104ba6a87aa722992931902023-11-18T00:36:15ZengMDPI AGBiomedicines2227-90592023-05-01115138210.3390/biomedicines11051382Advanced ImageJ Analysis in Degenerative Acquired Vitelliform Lesions Using Techniques Based on Optical Coherence TomographyIoana Damian0George-Adrian Muntean1Larisa-Bianca Galea-Holhoș2Simona-Delia Nicoară3Department of Ophthalmology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, RomaniaDepartment of Ophthalmology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, RomaniaDepartment of Anatomy, Faculty of Medicine and Pharmacy, University of Oradea, 1 Decembrie Street, 410068 Oradea, RomaniaDepartment of Ophthalmology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, RomaniaAcquired vitelliform lesions (AVLs) are associated with a large spectrum of retinal diseases, among which is age-related macular degeneration (AMD). The purpose of this study was to characterize AVLs’ evolution in AMD patients using optical coherence tomography (OCT) technology and ImageJ software. We measured AVLs’ size and density and followed their impacts over surrounding retinal layers. Average retinal pigment epithelium (RPE) thickness in the central 1 mm quadrant (45.89 ± 27.84 µm vs. 15.57 ± 1.40 µm) was significantly increased, as opposed to the outer nuclear layer (ONL) thickness, which was decreased (77.94 ± 18.30 µm vs. 88.64 ± 7.65 µm) in the vitelliform group compared to the control group. We found a continuous external limiting membrane (ELM) in 55.5% of the eyes compared to a continuous ellipsoid zone (EZ) in 22.2% of the eyes in the vitelliform group. The difference between the mean AVLs’ volume at baseline compared to the last visit for the nine eyes with ophthalmologic follow-up was not statistically significant (<i>p</i> = 0.725). The median follow-up duration was 11 months (range 5–56 months). Seven eyes (43.75%) were treated with intravitreal anti-vascular endothelium growth factor (anti-VEGF) agent injections, in which we noted a 6.43 ± 9 letter decrease in the best-corrected visual acuity (BCVA). The increased RPE thickness could suggest hyperplasia contrary to the decreased ONL, which could mirror the impact of the vitelliform lesion on photoreceptors (PR). Eyes that received anti-VEGF injections did not show signs of improvement regarding BCVA.https://www.mdpi.com/2227-9059/11/5/1382vitelliform lesionsoptical coherence tomographyimage analysisImageJanti-VEGF |
| spellingShingle | Ioana Damian George-Adrian Muntean Larisa-Bianca Galea-Holhoș Simona-Delia Nicoară Advanced ImageJ Analysis in Degenerative Acquired Vitelliform Lesions Using Techniques Based on Optical Coherence Tomography Biomedicines vitelliform lesions optical coherence tomography image analysis ImageJ anti-VEGF |
| title | Advanced ImageJ Analysis in Degenerative Acquired Vitelliform Lesions Using Techniques Based on Optical Coherence Tomography |
| title_full | Advanced ImageJ Analysis in Degenerative Acquired Vitelliform Lesions Using Techniques Based on Optical Coherence Tomography |
| title_fullStr | Advanced ImageJ Analysis in Degenerative Acquired Vitelliform Lesions Using Techniques Based on Optical Coherence Tomography |
| title_full_unstemmed | Advanced ImageJ Analysis in Degenerative Acquired Vitelliform Lesions Using Techniques Based on Optical Coherence Tomography |
| title_short | Advanced ImageJ Analysis in Degenerative Acquired Vitelliform Lesions Using Techniques Based on Optical Coherence Tomography |
| title_sort | advanced imagej analysis in degenerative acquired vitelliform lesions using techniques based on optical coherence tomography |
| topic | vitelliform lesions optical coherence tomography image analysis ImageJ anti-VEGF |
| url | https://www.mdpi.com/2227-9059/11/5/1382 |
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