Differentiated approach in the treatment of diffuse large B-cell lymphoma according to c-MYC and BCL2 status

Differentiated approach in the treatment of diffuse large B-cell lymphoma according to c-MYC and BCL2 status

Background. The treatment results of patients with diffuse large B-cell lymphoma (DLBCL) with c-MYC proto-oncogene and BCL2 protein positivity according to the CHOP-21 ± R scheme remain unsatisfactory, which dictates the need to intensify the therapy regimen. Due to the fact that most authors combin...

Full description

Bibliographic Details
Main Authors:	R. K. Karakulov, D. R. Kaydarova, Z. D. Dushimova, S. T. Gabbasova, G. A. Sagindykov, B. A. Nasipov, A. S. Dzhazyltaeva, N. A. Kemelbekov
Format:	Article
Language:	Russian
Published:	ABV-press 2022-01-01
Series:	Онкогематология
Subjects:	diffuse large b-cell lymphoma c-myc bcl2 immunohistochemistry fluorescent in situ hybridization polychemotherapy autologous hematopoietic stem cell transplantation event-free survival
Online Access:	https://oncohematology.abvpress.ru/ongm/article/view/516

Similar Items

MYC Immunohistochemistry Predicts MYC Rearrangements by FISH
by: Julum Nwanze, et al.
Published: (2017-09-01)

Prevalence and Prognostic Impact of MYC, BCL2, and BCL6 Rearrangements in Large B Cell Lymphoma Patients: A Multicenter Historical Cohort Study from Iran
by: Fatemeh Radmanesh, et al.
Published: (2024-04-01)

Targeted inhibition of DHODH is synergistic with BCL2 blockade in HGBCL with concurrent MYC and BCL2 rearrangement
by: Lin Liu, et al.
Published: (2024-06-01)

MYC overexpression but not MYC/BCL2 double expression predicts survival in bulky mass diffuse large B‐cell lymphoma patients
by: Yanjie Wang, et al.
Published: (2023-09-01)

Translating prognostic quantification of c-MYC and BCL2 from tissue microarrays to whole slide images in diffuse large B-cell lymphoma using deep learning
by: Thomas E. Tavolara, et al.
Published: (2024-01-01)

Evaluation of the Prognostic Importance of c-Myc and Bcl-2 Expressions and the Presence of Epstein-Barr Virus in Classical Hodgkin Lymphoma
by: Aydan KILIÇARSLAN, et al.
Published: (2018-09-01)

Generation of a Murine Model for c-MYC and BCL2 Co-expression B Cell Lymphomas
by: Zhenming Cai, et al.
Published: (2020-06-01)

Performance of MYC, BCL2, and BCL6 break-apart FISH in small biopsies with large B-cell lymphoma: a retrospective Cytopathology Hematopathology Interinstitutional Consortium study
by: Joshua R. Menke, et al.
Published: (2024-06-01)

Correlation of c-MYC, BCL2 and BCL6 proteins overexpression with prognosis in Syrian DLBCL Patients
by: Sulaf Ahmad Farhat Maghrabi, et al.
Published: (2024-09-01)

Autologous hematopoietic stem cell transplantation as first‐line consolidation therapy can improve the prognosis of diffuse large B‐cell lymphoma with high expression of MYC protein
by: Kai Hu, et al.
Published: (2019-07-01)

MYC’s Fine Line Between B Cell Development and Malignancy
by: Oriol de Barrios, et al.
Published: (2020-02-01)

The role of translocations involving c-MYC/8q24, BCL2/18q21 and/or BCL6/3q27 genes in patients with follicular lymphoma. Retrospective analysis of single - centre data
by: A E Misyurina, et al.
Published: (2019-07-01)

Clinicopathological analysis of diffuse large B-cell lymphoma using molecular biomarkers: a retrospective analysis from 7 Hungarian centers
by: Anett Balikó, et al.
Published: (2023-09-01)

Enhanced lipid metabolism confers the immunosuppressive tumor microenvironment in CD5-positive non-MYC/BCL2 double expressor lymphoma
by: Meng-Ke Liu, et al.
Published: (2022-10-01)

Intensive polychemotherapy efficacy in young adults with diffuse B-large cells lymphoma from germinal center cells
by: M. M. Bobkova, et al.
Published: (2022-11-01)

A digital method to interpret the C-MYC stain in diffuse large B cell lymphoma
by: Jayalakshmi Balakrishna, et al.
Published: (2022-01-01)

The effectiveness and reliability of autologous hematopoietic stem cell transplantation following chemotherapy in managing malignant lymphoma: a meta-analysis
by: Hend Ahmed, et al.
Published: (2025-02-01)

Bcl-2 Immunoexpression in Feline Epitheliotropic Intestinal T-Cell Lymphomas
by: Agustín Rebollada-Merino, et al.
Published: (2022-03-01)

Primary Diffuse Large B-Cell Lymphoma of the Breast with MYC and BCL2 Rearrangements with Terminal Deoxynucleotidyl Transferase Expression: A Case Report
by: Bassam Matar, et al.
Published: (2024-06-01)

Lessons from Using Genetically Engineered Mouse Models of MYC-Induced Lymphoma
by: René Winkler, et al.
Published: (2022-12-01)

Diffuse large B-cell lymphoma with concomitant c-MYC and BCL6 gene rearrangements with primary skin involvement: A case report and a review of literature
by: N G Gabeeva, et al.
Published: (2017-07-01)

Inhibition of bromodomain and extra-terminal proteins targets constitutively active NFκB and STAT signaling in lymphoma and influences the expression of the antiapoptotic proteins BCL2A1 and c-MYC
by: Nadja M. Pieper, et al.
Published: (2024-08-01)

Significance of Bcl-2 and Bcl-6 immunostaining in B-Non Hodgkin's lymphoma
by: Hanan Mohamed Mahmoud, et al.
Published: (2011-11-01)

Clinical practice optimization exploration and future prospects of autologous hematopoietic stem cell transplantation for lymphoma
by: JIN Zhengming
Published: (2022-02-01)

Mantle cell lymphoma and involvement of lacrimal glands and orbit
by: E.V. Vilchevskaia, et al.
Published: (2016-04-01)

Quality of life before autologous stem cells transplantation as prognostic factor in patients with malignant lymphomas
by: Yu. L. Shevchenko, et al.
Published: (2014-07-01)

Quality of life before autologous stem cells transplantation as prognostic factor in patients with malignant lymphomas
by: Yu. L. Shevchenko, et al.
Published: (2014-07-01)

Combined immunochemotherapy in patients with refractory/relapsed classical Hodgkin's lymphoma as a 2<sup>nd</sup> line treatment before autologous hematopoietic stem cell transplantation (preliminary results)
by: A. A. Mamedova, et al.
Published: (2022-07-01)

Alternative <i>c-MYC</i> mRNA Transcripts as an Additional Tool for c-Myc2 and c-MycS Production in BL60 Tumors
by: Dina Ibrahim, et al.
Published: (2022-06-01)

The role of auto-HSCT in extranodal natural killer/T cell lymphoma
by: Peng Yin-yin, et al.
Published: (2024-10-01)

The Myc Road to Hearing Restoration
by: Bernd Fritzsch, et al.
Published: (2012-09-01)

BET inhibition revealed varying MYC dependency mechanisms independent of gene alterations in aggressive B-cell lymphomas
by: Loris Delrieu, et al.
Published: (2024-12-01)

Decreased CD11c‐positive dendritic cells in the tumor microenvironment predict double‐hit/triple‐hit genotype and survival in diffuse large B‐cell lymphoma
by: Chang‐Tsu Yuan, et al.
Published: (2022-09-01)

C-Myc protein expression indicates unfavorable clinical outcome in surgically resected small cell lung cancer
by: Christian Lang, et al.
Published: (2024-02-01)

The structure of viral hepatitis and dynamics of cytolitic syndrome in patients with oncohaematological diseases
by: T. V. Antonova, et al.
Published: (2018-07-01)

Meta-analysis on the efficacy of allogeneic hematopoietic stem cell transplantation to treat malignant lymphoma
by: Zhao Jin, et al.
Published: (2024-05-01)

Application patterns and outcomes of hematopoietic stem cell transplantation in peripheral T-cell lymphoma patients: a multicenter real-world study in China
by: Hongye Gao, et al.
Published: (2024-08-01)

Day 100 Recovery of Absolute Number of Inhibitory KIR2DL2 and Activating NKp30 Natural Killer Cells Predicts Survival Post-Autologous Stem Cell Transplantation in Lymphomas
by: Luis F. Porrata, et al.
Published: (2024-08-01)

Clinical Efficacy and Prognostic Factors of Autologous Hematopoietic Stem Cell Transplantation for Hodgkin's Lymphoma in 38 Cases
by: HUANG Zhenghua, et al.
Published: (2022-09-01)

Specific Myocardial Lesion in a Patient with Diffuse Large B-Cell Lymphoma (a Case Report)
by: D. D. Sakaeva, et al.
Published: (2019-03-01)