Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential
Tannins are secondary metabolites that belong to the family of polyphenolic compounds and have gained a huge interest among researchers due to their versatile therapeutic potential. After lignin, these are the second most abundant polyphenols found in almost every plant part like stem, bark, fruit,...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2023-04-01
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| Series: | Exploration of Targeted Anti-tumor Therapy |
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| Online Access: | https://www.explorationpub.com/Journals/etat/Article/1002129 |
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| author | Rippin Vikas Beniwal Ajay Sharma Bikram Jit Singh Seema Ramniwas Katrin Sak Satish Kumar Anil K. Sharma |
| author_facet | Rippin Vikas Beniwal Ajay Sharma Bikram Jit Singh Seema Ramniwas Katrin Sak Satish Kumar Anil K. Sharma |
| author_sort | Rippin |
| collection | DOAJ |
| description | Tannins are secondary metabolites that belong to the family of polyphenolic compounds and have gained a huge interest among researchers due to their versatile therapeutic potential. After lignin, these are the second most abundant polyphenols found in almost every plant part like stem, bark, fruit, seed, leaves, etc. Depending upon their structural composition, these polyphenols can be divided into two distinct groups, namely condensed tannins and hydrolysable tannins. Hydrolysable tannins can be further divided into two types: gallotannins and ellagitannins. Gallotannins are formed by the esterification of D-glucose hydroxyl groups with gallic acid. The gallolyl moieties are bound by a depside bond. The current review focuses mainly on the anti-carcinogenic potential of recently discovered gallotannins, ginnalin A, and hamamelitannin (HAM). Both of these gallotannins possess two galloyl moieties linked to a core monosaccharide having anti-oxidant, anti-inflammatory, and anti-carcinogenic abilities. Ginnalin A is found in plants of the genus Acer whereas HAM is present in witch hazel plants. The biosynthetic pathway of ginnalin A along with the mechanism of the anti-cancer therapeutic potential of ginnalin A and HAM has been discussed. This review will certainly help researchers to work further on the chemo-therapeutic abilities of these two unique gallotannins. |
| first_indexed | 2024-04-09T14:24:31Z |
| format | Article |
| id | doaj.art-f944181ce4244118a593c5af1d4cf94c |
| institution | Directory Open Access Journal |
| issn | 2692-3114 |
| language | English |
| last_indexed | 2024-04-09T14:24:31Z |
| publishDate | 2023-04-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Targeted Anti-tumor Therapy |
| spelling | doaj.art-f944181ce4244118a593c5af1d4cf94c2023-05-04T09:24:29ZengOpen Exploration Publishing Inc.Exploration of Targeted Anti-tumor Therapy2692-31142023-04-014220821610.37349/etat.2023.00129Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potentialRippin0Vikas Beniwal1https://orcid.org/0000-0002-9152-3186Ajay Sharma2https://orcid.org/0000-0002-1555-1791Bikram Jit Singh3https://orcid.org/0000-0002-7250-0165Seema Ramniwas4https://orcid.org/0000-0002-4899-4687Katrin Sak5https://orcid.org/0000-0003-0736-2525Satish Kumar6https://orcid.org/0000-0003-2264-9006Anil K. Sharma7https://orcid.org/0000-0002-9768-1644Department of Biotechnology, Maharishi Markandeshar Engineering College, Maharishi Markandeshwar (Deemed to be University), Haryana 133207, IndiaDepartment of Microbiology, Central University of Haryana, Haryana 123029, IndiaDepartment of Chemistry, Career Point University, Hamirpur 176041, Himachal Pradesh, IndiaDepartment of Mechanical Engineering, M.M. Engineering College, Maharishi Markandeshwar (Deemed to be University), Haryana 133207, IndiaUniversity Centre for Research and Development, University Institute of Biotechnology Chandigarh University, Mohali 140413, IndiaNon-government Organization, Praeventio, Tartu 50407, EstoniaCollege of Horticulture and Forestry, Thunag, Dr. Y. S. Parmar University of Horticulture and Forestry, Solan 173230, IndiaDepartment of Biotechnology, Maharishi Markandeshar Engineering College, Maharishi Markandeshwar (Deemed to be University), Haryana 133207, IndiaTannins are secondary metabolites that belong to the family of polyphenolic compounds and have gained a huge interest among researchers due to their versatile therapeutic potential. After lignin, these are the second most abundant polyphenols found in almost every plant part like stem, bark, fruit, seed, leaves, etc. Depending upon their structural composition, these polyphenols can be divided into two distinct groups, namely condensed tannins and hydrolysable tannins. Hydrolysable tannins can be further divided into two types: gallotannins and ellagitannins. Gallotannins are formed by the esterification of D-glucose hydroxyl groups with gallic acid. The gallolyl moieties are bound by a depside bond. The current review focuses mainly on the anti-carcinogenic potential of recently discovered gallotannins, ginnalin A, and hamamelitannin (HAM). Both of these gallotannins possess two galloyl moieties linked to a core monosaccharide having anti-oxidant, anti-inflammatory, and anti-carcinogenic abilities. Ginnalin A is found in plants of the genus Acer whereas HAM is present in witch hazel plants. The biosynthetic pathway of ginnalin A along with the mechanism of the anti-cancer therapeutic potential of ginnalin A and HAM has been discussed. This review will certainly help researchers to work further on the chemo-therapeutic abilities of these two unique gallotannins.https://www.explorationpub.com/Journals/etat/Article/1002129tanninsgallotanninsginnalin aacertanninanti-carcinogenhamamelitannin |
| spellingShingle | Rippin Vikas Beniwal Ajay Sharma Bikram Jit Singh Seema Ramniwas Katrin Sak Satish Kumar Anil K. Sharma Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential Exploration of Targeted Anti-tumor Therapy tannins gallotannins ginnalin a acertannin anti-carcinogen hamamelitannin |
| title | Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential |
| title_full | Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential |
| title_fullStr | Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential |
| title_full_unstemmed | Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential |
| title_short | Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential |
| title_sort | ginnalin a and hamamelitannin the unique gallotannins with promising anti carcinogenic potential |
| topic | tannins gallotannins ginnalin a acertannin anti-carcinogen hamamelitannin |
| url | https://www.explorationpub.com/Journals/etat/Article/1002129 |
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