Controlled delivery of zoledronate improved bone formation locally in vivo.
Bisphosphonates (BPs) have been widely used in clinical treatment of bone diseases with increased bone resorption because of their strong affinity for bone and their inhibition of bone resorption. Recently, there has been growing interest in their improvement of bone formation. However, the effect o...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3950209?pdf=render |
| _version_ | 1818013886908989440 |
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| author | Wenlong Gou Xin Wang Jiang Peng Qiang Lu Yu Wang Aiyuan Wang Quanyi Guo Xupeng Gao Wenjing Xu Shibi Lu |
| author_facet | Wenlong Gou Xin Wang Jiang Peng Qiang Lu Yu Wang Aiyuan Wang Quanyi Guo Xupeng Gao Wenjing Xu Shibi Lu |
| author_sort | Wenlong Gou |
| collection | DOAJ |
| description | Bisphosphonates (BPs) have been widely used in clinical treatment of bone diseases with increased bone resorption because of their strong affinity for bone and their inhibition of bone resorption. Recently, there has been growing interest in their improvement of bone formation. However, the effect of local controlled delivery of BPs is unclear. We used polylactide acid-glycolic acid copolymer (PLGA) as a drug carrier to deliver various doses of the bisphosphonate zoledronate (Zol) into the distal femur of 8-week-old Sprague-Dawley rats. After 6 weeks, samples were harvested and analyzed by micro-CT and histology. The average bone mineral density and mineralized bone volume fraction were higher with medium- and high-dose PLGA-Zol (30 and 300 µg Zol, respectively) than control and low-dose Zol (3 µg PLGA-Zol; p<0.05). Local controlled delivery of Zol decreased the numbers of osteoclast and increased the numbers of osteoblast. Moreover, local controlled delivery of medium- and high-dose Zol accelerated the expression of bone-formation markers. PLGA used as a drug carrier for controlled delivery of Zol may promote local bone formation. |
| first_indexed | 2024-04-14T06:38:50Z |
| format | Article |
| id | doaj.art-f945666029ea4d22b7152b2f453a0d00 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T06:38:50Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f945666029ea4d22b7152b2f453a0d002022-12-22T02:07:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9131710.1371/journal.pone.0091317Controlled delivery of zoledronate improved bone formation locally in vivo.Wenlong GouXin WangJiang PengQiang LuYu WangAiyuan WangQuanyi GuoXupeng GaoWenjing XuShibi LuBisphosphonates (BPs) have been widely used in clinical treatment of bone diseases with increased bone resorption because of their strong affinity for bone and their inhibition of bone resorption. Recently, there has been growing interest in their improvement of bone formation. However, the effect of local controlled delivery of BPs is unclear. We used polylactide acid-glycolic acid copolymer (PLGA) as a drug carrier to deliver various doses of the bisphosphonate zoledronate (Zol) into the distal femur of 8-week-old Sprague-Dawley rats. After 6 weeks, samples were harvested and analyzed by micro-CT and histology. The average bone mineral density and mineralized bone volume fraction were higher with medium- and high-dose PLGA-Zol (30 and 300 µg Zol, respectively) than control and low-dose Zol (3 µg PLGA-Zol; p<0.05). Local controlled delivery of Zol decreased the numbers of osteoclast and increased the numbers of osteoblast. Moreover, local controlled delivery of medium- and high-dose Zol accelerated the expression of bone-formation markers. PLGA used as a drug carrier for controlled delivery of Zol may promote local bone formation.http://europepmc.org/articles/PMC3950209?pdf=render |
| spellingShingle | Wenlong Gou Xin Wang Jiang Peng Qiang Lu Yu Wang Aiyuan Wang Quanyi Guo Xupeng Gao Wenjing Xu Shibi Lu Controlled delivery of zoledronate improved bone formation locally in vivo. PLoS ONE |
| title | Controlled delivery of zoledronate improved bone formation locally in vivo. |
| title_full | Controlled delivery of zoledronate improved bone formation locally in vivo. |
| title_fullStr | Controlled delivery of zoledronate improved bone formation locally in vivo. |
| title_full_unstemmed | Controlled delivery of zoledronate improved bone formation locally in vivo. |
| title_short | Controlled delivery of zoledronate improved bone formation locally in vivo. |
| title_sort | controlled delivery of zoledronate improved bone formation locally in vivo |
| url | http://europepmc.org/articles/PMC3950209?pdf=render |
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