Macrophage Migration Inhibitory Factor (MIF) Promotes Increased Proportions of the Highly Permissive Th17-like Cell Profile during HIV Infection

Macrophage Migration Inhibitory Factor (MIF) Promotes Increased Proportions of the Highly Permissive Th17-like Cell Profile during HIV Infection

In this study, we evaluate the role of the MIF/CD74 axis in the functionality of CD4<sup>+</sup> T lymphocytes (CD4TL) during HIV infection. MDMs from healthy donors were infected with a R5-tropic or Transmitted/Founder (T/F) HIV strain. At day 11 post-MDM infection, allogeneic co-cultur...

Full description

Bibliographic Details
Main Authors: César Trifone, Lucía Baquero, Alejandro Czernikier, Paula Benencio, Lin Leng, Natalia Laufer, María Florencia Quiroga, Richard Bucala, Yanina Ghiglione, Gabriela Turk
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Viruses
Subjects:
HIV
MIF
MDM/CD4TL co-culture
immune pathogenesis
Online Access:https://www.mdpi.com/1999-4915/14/10/2218

Internet

https://www.mdpi.com/1999-4915/14/10/2218

Similar Items