Perspective: rethinking therapeutic strategies in oncology
Immuno-oncology has revolutionized cancer care, drug development, the design of clinical trials, standard treatment paradigms, and the evaluation of response to therapy. These are all areas, however, that have not fully incorporated principles of tumor immunology. Insufficient emphasis is put on the...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1335987/full |
| _version_ | 1797360010319101952 |
|---|---|
| author | Edward F. Patz Edward F. Patz Elizabeth B. Gottlin George R. Simon |
| author_facet | Edward F. Patz Edward F. Patz Elizabeth B. Gottlin George R. Simon |
| author_sort | Edward F. Patz |
| collection | DOAJ |
| description | Immuno-oncology has revolutionized cancer care, drug development, the design of clinical trials, standard treatment paradigms, and the evaluation of response to therapy. These are all areas, however, that have not fully incorporated principles of tumor immunology. Insufficient emphasis is put on the effect drugs have on the immune system, and specifically, the impact that multiple lines of therapy can have on the functioning of the immune system, hindering a robust anti-tumor immune response. A paradigm shift in how we approach the development of novel immunotherapeutic agents is necessary to facilitate the effective improvements in patient outcomes. |
| first_indexed | 2024-03-08T15:32:11Z |
| format | Article |
| id | doaj.art-f9485eae69664fc9a1e960c31b31dc8d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T15:32:11Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-f9485eae69664fc9a1e960c31b31dc8d2024-01-10T04:29:11ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-01-011310.3389/fonc.2023.13359871335987Perspective: rethinking therapeutic strategies in oncologyEdward F. Patz0Edward F. Patz1Elizabeth B. Gottlin2George R. Simon3Department of Radiology, Duke University School of Medicine, Durham, NC, United StatesDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, United StatesDepartment of Radiology, Duke University School of Medicine, Durham, NC, United StatesDepartment of Medical Oncology at Advent Health, Moffitt Cancer Center, Tampa, FL, United StatesImmuno-oncology has revolutionized cancer care, drug development, the design of clinical trials, standard treatment paradigms, and the evaluation of response to therapy. These are all areas, however, that have not fully incorporated principles of tumor immunology. Insufficient emphasis is put on the effect drugs have on the immune system, and specifically, the impact that multiple lines of therapy can have on the functioning of the immune system, hindering a robust anti-tumor immune response. A paradigm shift in how we approach the development of novel immunotherapeutic agents is necessary to facilitate the effective improvements in patient outcomes.https://www.frontiersin.org/articles/10.3389/fonc.2023.1335987/fullimmuno-oncologytumor microenvironmentimmunosuppressiononcology clinical trialsresponse evaluation |
| spellingShingle | Edward F. Patz Edward F. Patz Elizabeth B. Gottlin George R. Simon Perspective: rethinking therapeutic strategies in oncology Frontiers in Oncology immuno-oncology tumor microenvironment immunosuppression oncology clinical trials response evaluation |
| title | Perspective: rethinking therapeutic strategies in oncology |
| title_full | Perspective: rethinking therapeutic strategies in oncology |
| title_fullStr | Perspective: rethinking therapeutic strategies in oncology |
| title_full_unstemmed | Perspective: rethinking therapeutic strategies in oncology |
| title_short | Perspective: rethinking therapeutic strategies in oncology |
| title_sort | perspective rethinking therapeutic strategies in oncology |
| topic | immuno-oncology tumor microenvironment immunosuppression oncology clinical trials response evaluation |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1335987/full |
| work_keys_str_mv | AT edwardfpatz perspectiverethinkingtherapeuticstrategiesinoncology AT edwardfpatz perspectiverethinkingtherapeuticstrategiesinoncology AT elizabethbgottlin perspectiverethinkingtherapeuticstrategiesinoncology AT georgersimon perspectiverethinkingtherapeuticstrategiesinoncology |