Visualization of the binding between gintonin, a Panax ginseng-derived LPA receptor ligand, and the LPA receptor subtypes and transactivation of the EGF receptor

Visualization of the binding between gintonin, a Panax ginseng-derived LPA receptor ligand, and the LPA receptor subtypes and transactivation of the EGF receptor

Background: Gintonin is a ginseng-derived exogenous G-protein-coupled lysophosphatidic acid (LPA) receptor ligand. Gintonin exerts its neuronal and non-neuronal in vitro and in vivo effects through LPA receptor subtypes. However, it is unknown whether gintonin can bind to the plasma membrane of cell...

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Bibliographic Details
Main Authors: Sun-Hye Choi, Ra Mi Lee, Han-Sung Cho, Sung Hee Hwang, Hong-Ik Hwang, Hyewhon Rhim, Hyoung-Chun Kim, Do-Geun Kim, Ik-Hyun Cho, Seung-Yeol Nah
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Journal of Ginseng Research
Subjects:
Gintonin
Gintonin-biotin conjugates
LPA receptor co-localization
EGF receptor
Transactivation
Online Access:http://www.sciencedirect.com/science/article/pii/S1226845321001573

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