Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy
Originally approved by the U.S. Food and Drug Administration (FDA) for its antihistamine properties, clemastine can also promote white matter integrity and has shown promise in the treatment of demyelinating diseases such as multiple sclerosis. Here, we conducted an in-depth analysis of the feasibil...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/11/1728 |
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| author | Jana Krystofova Mike Yasmine White Rachel S. Hutchings Christian Vento Janica Ha Ariana Iranmahboub Hadiya Manzoor Anya Gunewardena Cheryl Cheah Aijun Wang Brian D. Goudy Satyan Lakshminrusimha Janel Long-Boyle Jeffrey R. Fineman Donna M. Ferriero Emin Maltepe |
| author_facet | Jana Krystofova Mike Yasmine White Rachel S. Hutchings Christian Vento Janica Ha Ariana Iranmahboub Hadiya Manzoor Anya Gunewardena Cheryl Cheah Aijun Wang Brian D. Goudy Satyan Lakshminrusimha Janel Long-Boyle Jeffrey R. Fineman Donna M. Ferriero Emin Maltepe |
| author_sort | Jana Krystofova Mike |
| collection | DOAJ |
| description | Originally approved by the U.S. Food and Drug Administration (FDA) for its antihistamine properties, clemastine can also promote white matter integrity and has shown promise in the treatment of demyelinating diseases such as multiple sclerosis. Here, we conducted an in-depth analysis of the feasibility, safety, and neuroprotective efficacy of clemastine administration in near-term lambs (<i>n</i> = 25, 141–143 days) following a global ischemic insult induced via an umbilical cord occlusion (UCO) model. Lambs were randomly assigned to receive clemastine or placebo postnatally, and outcomes were assessed over a six-day period. Clemastine administration was well tolerated. While treated lambs demonstrated improvements in inflammatory scores, their neurodevelopmental outcomes were unchanged. |
| first_indexed | 2024-03-09T16:56:16Z |
| format | Article |
| id | doaj.art-f94acf4a9f4548449f83fd47924aaad4 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T16:56:16Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-f94acf4a9f4548449f83fd47924aaad42023-11-24T14:35:39ZengMDPI AGChildren2227-90672023-10-011011172810.3390/children10111728Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic EncephalopathyJana Krystofova Mike0Yasmine White1Rachel S. Hutchings2Christian Vento3Janica Ha4Ariana Iranmahboub5Hadiya Manzoor6Anya Gunewardena7Cheryl Cheah8Aijun Wang9Brian D. Goudy10Satyan Lakshminrusimha11Janel Long-Boyle12Jeffrey R. Fineman13Donna M. Ferriero14Emin Maltepe15Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USADepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USADepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USADepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USADepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USADepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USADepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USADepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USADepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USADepartment of Biomedical Engineering, University of California Davis, Davis, CA 95817, USADepartment of Pediatrics, University of California Davis, Davis, CA 95817, USADepartment of Pediatrics, University of California Davis, Davis, CA 95817, USASchool of Pharmacy, University of California San Francisco, San Francisco, CA 94143, USADepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USADepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USADepartment of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USAOriginally approved by the U.S. Food and Drug Administration (FDA) for its antihistamine properties, clemastine can also promote white matter integrity and has shown promise in the treatment of demyelinating diseases such as multiple sclerosis. Here, we conducted an in-depth analysis of the feasibility, safety, and neuroprotective efficacy of clemastine administration in near-term lambs (<i>n</i> = 25, 141–143 days) following a global ischemic insult induced via an umbilical cord occlusion (UCO) model. Lambs were randomly assigned to receive clemastine or placebo postnatally, and outcomes were assessed over a six-day period. Clemastine administration was well tolerated. While treated lambs demonstrated improvements in inflammatory scores, their neurodevelopmental outcomes were unchanged.https://www.mdpi.com/2227-9067/10/11/1728ovine modelneonatesbrain hypoxia-ischemiaclemastineasphyxia |
| spellingShingle | Jana Krystofova Mike Yasmine White Rachel S. Hutchings Christian Vento Janica Ha Ariana Iranmahboub Hadiya Manzoor Anya Gunewardena Cheryl Cheah Aijun Wang Brian D. Goudy Satyan Lakshminrusimha Janel Long-Boyle Jeffrey R. Fineman Donna M. Ferriero Emin Maltepe Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy Children ovine model neonates brain hypoxia-ischemia clemastine asphyxia |
| title | Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy |
| title_full | Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy |
| title_fullStr | Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy |
| title_full_unstemmed | Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy |
| title_short | Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy |
| title_sort | effect of clemastine on neurophysiological outcomes in an ovine model of neonatal hypoxic ischemic encephalopathy |
| topic | ovine model neonates brain hypoxia-ischemia clemastine asphyxia |
| url | https://www.mdpi.com/2227-9067/10/11/1728 |
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