New twist in the regulation of cyclin D1
Among the cell cycle-related mammalian cyclins, cyclin D1 is more closely connected with cell proliferation in response to extracellular signals than the cell cycle clock itself. Because both its mRNA and protein are labile, the intracellular abundance of cyclin D1 is thought to be largely regulated...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2010-12-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc.2010.029 |
| _version_ | 1818670393860292608 |
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| author | Kato Jun-ya Yoneda-Kato Noriko |
| author_facet | Kato Jun-ya Yoneda-Kato Noriko |
| author_sort | Kato Jun-ya |
| collection | DOAJ |
| description | Among the cell cycle-related mammalian cyclins, cyclin D1 is more closely connected with cell proliferation in response to extracellular signals than the cell cycle clock itself. Because both its mRNA and protein are labile, the intracellular abundance of cyclin D1 is thought to be largely regulated at the level of transcription. However, recent findings suggest that, in certain cell types, cyclin D1 is post-translationally regulated, and a disturbance of this regulatory mechanism induces aberrant entry into the cell cycle and proliferation, sometimes leading to diseases such as cancer. In this review, we summarize recent findings and discuss the physiological role and cellular function of the novel mechanism of regulation of cyclin D1 in terms of the control of cell proliferation. |
| first_indexed | 2024-12-17T07:07:24Z |
| format | Article |
| id | doaj.art-f94d2c15b09f46bf9156858e74c8bdde |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-17T07:07:24Z |
| publishDate | 2010-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-f94d2c15b09f46bf9156858e74c8bdde2022-12-21T21:59:07ZengDe GruyterBiomolecular Concepts1868-50211868-503X2010-12-0115-640340910.1515/bmc.2010.029New twist in the regulation of cyclin D1Kato Jun-ya0Yoneda-Kato Noriko1Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara 630-0101, JapanGraduate School of Biological Sciences, Nara Institute of Science and Technology, Nara 630-0101, JapanAmong the cell cycle-related mammalian cyclins, cyclin D1 is more closely connected with cell proliferation in response to extracellular signals than the cell cycle clock itself. Because both its mRNA and protein are labile, the intracellular abundance of cyclin D1 is thought to be largely regulated at the level of transcription. However, recent findings suggest that, in certain cell types, cyclin D1 is post-translationally regulated, and a disturbance of this regulatory mechanism induces aberrant entry into the cell cycle and proliferation, sometimes leading to diseases such as cancer. In this review, we summarize recent findings and discuss the physiological role and cellular function of the novel mechanism of regulation of cyclin D1 in terms of the control of cell proliferation.https://doi.org/10.1515/bmc.2010.029cancercell cyclecell proliferationcyclin dcytoplasmic retentiondegradatione3 ubiquitin ligasenuclear export |
| spellingShingle | Kato Jun-ya Yoneda-Kato Noriko New twist in the regulation of cyclin D1 Biomolecular Concepts cancer cell cycle cell proliferation cyclin d cytoplasmic retention degradation e3 ubiquitin ligase nuclear export |
| title | New twist in the regulation of cyclin D1 |
| title_full | New twist in the regulation of cyclin D1 |
| title_fullStr | New twist in the regulation of cyclin D1 |
| title_full_unstemmed | New twist in the regulation of cyclin D1 |
| title_short | New twist in the regulation of cyclin D1 |
| title_sort | new twist in the regulation of cyclin d1 |
| topic | cancer cell cycle cell proliferation cyclin d cytoplasmic retention degradation e3 ubiquitin ligase nuclear export |
| url | https://doi.org/10.1515/bmc.2010.029 |
| work_keys_str_mv | AT katojunya newtwistintheregulationofcyclind1 AT yonedakatonoriko newtwistintheregulationofcyclind1 |