The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC.

The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC.

p150, product of the SALL2 gene, is a binding partner of the polyoma virus large T antigen and a putative tumor suppressor. p150 binds to the nuclease hypersensitive element of the c-MYC promoter and represses c-MYC transcription. Overexpression of p150 in human ovarian surface epithelial cells lead...

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Bibliographic Details
Main Authors: Chang Kyoo Sung, Hyungshin Yim, Hongcang Gu, Dawei Li, Erik Andrews, Sekhar Duraisamy, Cheng Li, Ronny Drapkin, Thomas Benjamin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3460914?pdf=render

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