Cryo‐EM structure of orphan G protein‐coupled receptor GPR21

Cryo‐EM structure of orphan G protein‐coupled receptor GPR21

Abstract GPR21 belongs to class A orphan G protein‐coupled receptor (GPCR). The endogenous ligands for human GPR21 remain unidentified. GPR21 expression is associated with developing type 2 diabetes (T2DM), a multifactorial metabolic disease caused by pancreatic β‐cell dysfunction, decreasing insuli...

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Bibliographic Details
Main Authors: Thian‐Sze Wong, Wei Gao, Geng Chen, Chen Qiu, Guodong He, Fang Ye, Zhangsong Wu, Zicheng Zeng, Yang Du
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:MedComm
Subjects:
cryo‐EM
ECL2
GPCR
GPR21
orphan receptor
Online Access:https://doi.org/10.1002/mco2.205

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