Alternative Splicing of RAD6B and Not RAD6A is Selectively Increased in Melanoma: Identification and Functional Characterization

Alternative Splicing of RAD6B and Not RAD6A is Selectively Increased in Melanoma: Identification and Functional Characterization

Rad6B, a principal component of the translesion synthesis pathway, and activator of canonical Wnt signaling, plays an essential role in cutaneous melanoma development and progression. As Rad6 is encoded by two genes, namely, <i>UBE2A</i> (<i>RAD</i><i>6A</i>) and...

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Bibliographic Details
Main Authors: Ambikai Gajan, Carly E. Martin, Seongho Kim, Milap Joshi, Sharon K. Michelhaugh, Ido Sloma, Sandeep Mittal, Steven Firestine, Malathy P. V. Shekhar
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cells
Subjects:
melanoma
histone ubiquitination
alternative splicing
exon skipping
whole exome sequencing
Online Access:https://www.mdpi.com/2073-4409/8/11/1375

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