The past and present of paraoxonase enzyme: Its role in the cardiovascular system and some diseases
Although paraoxonase is synthesized in many tissues including the heart, colon, kidneys, lungs, small intestines and brain, its major locus of synthesis is the liver. PON1 is in close association with apolipoproteins and protects LDL against oxidation. It was reported that PON1 quantities dropped to...
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2012-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2012/1452-82581203161A.pdf |
| _version_ | 1818441049200132096 |
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| author | Aydin Suleyman Sahin İbrahim Aydin Suna Aksoy Aziz Citil Cihan |
| author_facet | Aydin Suleyman Sahin İbrahim Aydin Suna Aksoy Aziz Citil Cihan |
| author_sort | Aydin Suleyman |
| collection | DOAJ |
| description | Although paraoxonase is synthesized in many tissues including the heart, colon, kidneys, lungs, small intestines and brain, its major locus of synthesis is the liver. PON1 is in close association with apolipoproteins and protects LDL against oxidation. It was reported that PON1 quantities dropped to 40 times lower than normal in cardiovascular diseases and diseases like diabetes, ulcerative colitis, Crohn's disease, chronic renal failure, SLE, Behcet's disease, cancer, hepatitis B, obesity, metabolic syndrome, Alzheimer's and dementia. It is speculated that the concerning decline in serum PON1 amount results from single nucleotide polymorphism in the coding (Q192R, L55M) and promoter (T-108C) sites of the PON1 gene. Additionally, circulating amounts of PON1 are affected by vitamins, antioxidants, fatty acids, dietary factors, drugs, age and lifestyle. This collection attempts to review and examine the past and present studies of paraoxonase and its relation with the cardiovascular system and some relevant diseases. |
| first_indexed | 2024-12-14T18:22:04Z |
| format | Article |
| id | doaj.art-f951e5d7d79147cfb2020bf11d1b931f |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-14T18:22:04Z |
| publishDate | 2012-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-f951e5d7d79147cfb2020bf11d1b931f2022-12-21T22:52:03ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662012-01-013131611731452-82581203161AThe past and present of paraoxonase enzyme: Its role in the cardiovascular system and some diseasesAydin Suleyman0Sahin İbrahim1Aydin Suna2Aksoy Aziz3Citil Cihan4Department of Medical Biochemistry and Clinical Biochemistry (Firat Hormones Research Group), Medical Faculty, Firat University, Elazig, TurkeyDepartment of Nutrition and Dietetics, Erzincan University, Erzincan, TurkeyDepartment of Cardiovascular Surgery, Elazig State Hospital, Elazig, TurkeyDepartment of Nutrition and Dietetics, Bitlis Eren University, Bitlis, TurkeyDepartment of Biological Science (Biochemistry Section), Firat University, Elazig, TurkeyAlthough paraoxonase is synthesized in many tissues including the heart, colon, kidneys, lungs, small intestines and brain, its major locus of synthesis is the liver. PON1 is in close association with apolipoproteins and protects LDL against oxidation. It was reported that PON1 quantities dropped to 40 times lower than normal in cardiovascular diseases and diseases like diabetes, ulcerative colitis, Crohn's disease, chronic renal failure, SLE, Behcet's disease, cancer, hepatitis B, obesity, metabolic syndrome, Alzheimer's and dementia. It is speculated that the concerning decline in serum PON1 amount results from single nucleotide polymorphism in the coding (Q192R, L55M) and promoter (T-108C) sites of the PON1 gene. Additionally, circulating amounts of PON1 are affected by vitamins, antioxidants, fatty acids, dietary factors, drugs, age and lifestyle. This collection attempts to review and examine the past and present studies of paraoxonase and its relation with the cardiovascular system and some relevant diseases.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2012/1452-82581203161A.pdfparaoxonasepolymorphismcardiovascular system diseases |
| spellingShingle | Aydin Suleyman Sahin İbrahim Aydin Suna Aksoy Aziz Citil Cihan The past and present of paraoxonase enzyme: Its role in the cardiovascular system and some diseases Journal of Medical Biochemistry paraoxonase polymorphism cardiovascular system diseases |
| title | The past and present of paraoxonase enzyme: Its role in the cardiovascular system and some diseases |
| title_full | The past and present of paraoxonase enzyme: Its role in the cardiovascular system and some diseases |
| title_fullStr | The past and present of paraoxonase enzyme: Its role in the cardiovascular system and some diseases |
| title_full_unstemmed | The past and present of paraoxonase enzyme: Its role in the cardiovascular system and some diseases |
| title_short | The past and present of paraoxonase enzyme: Its role in the cardiovascular system and some diseases |
| title_sort | past and present of paraoxonase enzyme its role in the cardiovascular system and some diseases |
| topic | paraoxonase polymorphism cardiovascular system diseases |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2012/1452-82581203161A.pdf |
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