Perspectives of herbs and their natural compounds, and herb formulas on treating diverse diseases through regulating complicated JAK/STAT signaling
JAK/STAT signaling pathways are closely associated with multiple biological processes involved in cell proliferation, apoptosis, inflammation, differentiation, immune response, and epigenetics. Abnormal activation of the STAT pathway can contribute to disease progressions under various conditions. M...
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| Format: | Article |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.993862/full |
| _version_ | 1798030358109749248 |
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| author | Jian-Yu Chen Xiao-Yun Tian Shan-Shan Wei Ying-Jie Yang Shan Deng Chun-Jie Jiao Can-Jian Wang Ke-Dan Chu Xue-Qin Ma Wei Xu |
| author_facet | Jian-Yu Chen Xiao-Yun Tian Shan-Shan Wei Ying-Jie Yang Shan Deng Chun-Jie Jiao Can-Jian Wang Ke-Dan Chu Xue-Qin Ma Wei Xu |
| author_sort | Jian-Yu Chen |
| collection | DOAJ |
| description | JAK/STAT signaling pathways are closely associated with multiple biological processes involved in cell proliferation, apoptosis, inflammation, differentiation, immune response, and epigenetics. Abnormal activation of the STAT pathway can contribute to disease progressions under various conditions. Moreover, tofacitinib and baricitinib as the JAK/STAT inhibitors have been recently approved by the FDA for rheumatology disease treatment. Therefore, influences on the STAT signaling pathway have potential and perspective approaches for diverse diseases. Chinese herbs in traditional Chinese medicine (TCM), which are widespread throughout China, are the gold resources of China and have been extensively used for treating multiple diseases for thousands of years. However, Chinese herbs and herb formulas are characterized by complicated components, resulting in various targets and pathways in treating diseases, which limits their approval and applications. With the development of chemistry and pharmacology, active ingredients of TCM and herbs and underlying mechanisms have been further identified and confirmed by pharmacists and chemists, which improved, to some extent, awkward limitations, approval, and applications regarding TCM and herbs. In this review, we summarized various herbs, herb formulas, natural compounds, and phytochemicals isolated from herbs that have the potential for regulating multiple biological processes via modulation of the JAK/STAT signaling pathway based on the published work. Our study will provide support for revealing TCM, their active compounds that treat diseases, and the underlying mechanism, further improving the rapid spread of TCM to the world. |
| first_indexed | 2024-04-11T19:40:09Z |
| format | Article |
| id | doaj.art-f9522a7548d2456c92f65d743f134c4d |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T19:40:09Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-f9522a7548d2456c92f65d743f134c4d2022-12-22T04:06:44ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-10-011310.3389/fphar.2022.993862993862Perspectives of herbs and their natural compounds, and herb formulas on treating diverse diseases through regulating complicated JAK/STAT signalingJian-Yu Chen0 Xiao-Yun Tian1Shan-Shan Wei2Ying-Jie Yang3Shan Deng4Chun-Jie Jiao5Can-Jian Wang6Ke-Dan Chu7Xue-Qin Ma8Wei Xu9Department of Pharmacology, School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaDepartment of Pharmacology, School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaSchool of Pharmacy, Second Military Medical University, Shanghai, ChinaDepartment of Pharmacology, School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaDepartment of Pharmacology, School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaThird Affiliated Hospital of Henan University of Traditional Chinese Medicine, ZhengZhou, ChinaJiangxi University of Chinese Medicine, Nanchang, ChinaDepartment of Pharmacology, School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaKey Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education, Department of Pharmaceutical Analysis, School of Pharmacy, Ningxia Medical University, Yinchuan, ChinaDepartment of Pharmacology, School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaJAK/STAT signaling pathways are closely associated with multiple biological processes involved in cell proliferation, apoptosis, inflammation, differentiation, immune response, and epigenetics. Abnormal activation of the STAT pathway can contribute to disease progressions under various conditions. Moreover, tofacitinib and baricitinib as the JAK/STAT inhibitors have been recently approved by the FDA for rheumatology disease treatment. Therefore, influences on the STAT signaling pathway have potential and perspective approaches for diverse diseases. Chinese herbs in traditional Chinese medicine (TCM), which are widespread throughout China, are the gold resources of China and have been extensively used for treating multiple diseases for thousands of years. However, Chinese herbs and herb formulas are characterized by complicated components, resulting in various targets and pathways in treating diseases, which limits their approval and applications. With the development of chemistry and pharmacology, active ingredients of TCM and herbs and underlying mechanisms have been further identified and confirmed by pharmacists and chemists, which improved, to some extent, awkward limitations, approval, and applications regarding TCM and herbs. In this review, we summarized various herbs, herb formulas, natural compounds, and phytochemicals isolated from herbs that have the potential for regulating multiple biological processes via modulation of the JAK/STAT signaling pathway based on the published work. Our study will provide support for revealing TCM, their active compounds that treat diseases, and the underlying mechanism, further improving the rapid spread of TCM to the world.https://www.frontiersin.org/articles/10.3389/fphar.2022.993862/fullnatural compoundsherbsherb formulastraditional Chinese medicines (TCMs)JAK/STATs |
| spellingShingle | Jian-Yu Chen Xiao-Yun Tian Shan-Shan Wei Ying-Jie Yang Shan Deng Chun-Jie Jiao Can-Jian Wang Ke-Dan Chu Xue-Qin Ma Wei Xu Perspectives of herbs and their natural compounds, and herb formulas on treating diverse diseases through regulating complicated JAK/STAT signaling Frontiers in Pharmacology natural compounds herbs herb formulas traditional Chinese medicines (TCMs) JAK/STATs |
| title | Perspectives of herbs and their natural compounds, and herb formulas on treating diverse diseases through regulating complicated JAK/STAT signaling |
| title_full | Perspectives of herbs and their natural compounds, and herb formulas on treating diverse diseases through regulating complicated JAK/STAT signaling |
| title_fullStr | Perspectives of herbs and their natural compounds, and herb formulas on treating diverse diseases through regulating complicated JAK/STAT signaling |
| title_full_unstemmed | Perspectives of herbs and their natural compounds, and herb formulas on treating diverse diseases through regulating complicated JAK/STAT signaling |
| title_short | Perspectives of herbs and their natural compounds, and herb formulas on treating diverse diseases through regulating complicated JAK/STAT signaling |
| title_sort | perspectives of herbs and their natural compounds and herb formulas on treating diverse diseases through regulating complicated jak stat signaling |
| topic | natural compounds herbs herb formulas traditional Chinese medicines (TCMs) JAK/STATs |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.993862/full |
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