Effect of optimized transcranial direct current stimulation on motor cortex activation in patients with sub-acute or chronic stroke: a study protocol for a single-blinded cross-over randomized control trial
IntroductionTranscranial direct current stimulation (tDCS) has shown positive but inconsistent results in stroke rehabilitation. This could be attributed to inter-individual variations in brain characteristics and stroke lesions, which limit the use of a single tDCS protocol for all post-stroke pati...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1328727/full |
| _version_ | 1797384318547394560 |
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| author | TaeYeong Kim Jhosedyn Carolaym Salazar Fajardo Hanna Jang Juwon Lee Yeonkyung Kim Gowun Kim Donghyeon Kim |
| author_facet | TaeYeong Kim Jhosedyn Carolaym Salazar Fajardo Hanna Jang Juwon Lee Yeonkyung Kim Gowun Kim Donghyeon Kim |
| author_sort | TaeYeong Kim |
| collection | DOAJ |
| description | IntroductionTranscranial direct current stimulation (tDCS) has shown positive but inconsistent results in stroke rehabilitation. This could be attributed to inter-individual variations in brain characteristics and stroke lesions, which limit the use of a single tDCS protocol for all post-stroke patients. Optimizing the electrode location in tDCS for each individual using magnetic resonance imaging (MRI) to generate three-dimensional computer models and calculate the electric field (E-field) induced by tDCS at a specific target point in the primary motor cortex may help reduce these inconsistencies. In stroke rehabilitation, locating the optimal position that generates a high E-field in a target area can influence motor recovery. Therefore, this study was designed to determine the effect of personalized tDCS electrode positions on hand-knob activation in post-stroke patients.MethodThis is a crossover study with a sample size of 50 participants, who will be randomly assigned to one of six groups and will receive one session of either optimized-active, conventional-active, or sham tDCS, with 24 h between sessions. The tDCS parameters will be 1 mA (5 × 5 cm electrodes) for 20 min. The motor-evoked potential (MEP) will be recorded before and after each session over the target area (motor cortex hand-knob) and the MEP hotspot. The MEP amplitude at the target location will be the primary outcome.DiscussionWe hypothesize that the optimized-active tDCS session would show a greater increase in MEP amplitude over the target area in patients with subacute and chronic stroke than conventional and sham tDCS sessions.Clinical trial registration:https://cris.nih.go.kr, identifier KCT0007536. |
| first_indexed | 2024-03-08T21:34:48Z |
| format | Article |
| id | doaj.art-f952e57d767e4da39900df7cbbac7aa7 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-08T21:34:48Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-f952e57d767e4da39900df7cbbac7aa72023-12-21T04:16:17ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-12-011710.3389/fnins.2023.13287271328727Effect of optimized transcranial direct current stimulation on motor cortex activation in patients with sub-acute or chronic stroke: a study protocol for a single-blinded cross-over randomized control trialTaeYeong Kim0Jhosedyn Carolaym Salazar Fajardo1Hanna Jang2Juwon Lee3Yeonkyung Kim4Gowun Kim5Donghyeon Kim6Research Institute, Neurophet Inc., Seoul, Republic of KoreaResearch Institute, Neurophet Inc., Seoul, Republic of KoreaResearch Institute, Neurophet Inc., Seoul, Republic of KoreaDepartment of Rehabilitation Medicine, Kangwon National University Hospital, Chuncheon-si, Republic of KoreaDepartment of Rehabilitation Medicine, Kangwon National University Hospital, Chuncheon-si, Republic of KoreaDepartment of Rehabilitation Medicine, Kangwon National University Hospital, Chuncheon-si, Republic of KoreaResearch Institute, Neurophet Inc., Seoul, Republic of KoreaIntroductionTranscranial direct current stimulation (tDCS) has shown positive but inconsistent results in stroke rehabilitation. This could be attributed to inter-individual variations in brain characteristics and stroke lesions, which limit the use of a single tDCS protocol for all post-stroke patients. Optimizing the electrode location in tDCS for each individual using magnetic resonance imaging (MRI) to generate three-dimensional computer models and calculate the electric field (E-field) induced by tDCS at a specific target point in the primary motor cortex may help reduce these inconsistencies. In stroke rehabilitation, locating the optimal position that generates a high E-field in a target area can influence motor recovery. Therefore, this study was designed to determine the effect of personalized tDCS electrode positions on hand-knob activation in post-stroke patients.MethodThis is a crossover study with a sample size of 50 participants, who will be randomly assigned to one of six groups and will receive one session of either optimized-active, conventional-active, or sham tDCS, with 24 h between sessions. The tDCS parameters will be 1 mA (5 × 5 cm electrodes) for 20 min. The motor-evoked potential (MEP) will be recorded before and after each session over the target area (motor cortex hand-knob) and the MEP hotspot. The MEP amplitude at the target location will be the primary outcome.DiscussionWe hypothesize that the optimized-active tDCS session would show a greater increase in MEP amplitude over the target area in patients with subacute and chronic stroke than conventional and sham tDCS sessions.Clinical trial registration:https://cris.nih.go.kr, identifier KCT0007536.https://www.frontiersin.org/articles/10.3389/fnins.2023.1328727/fullbrain modelingstrokenon-invasive brain stimulationtranscranial direct current stimulationneurorehabilitation |
| spellingShingle | TaeYeong Kim Jhosedyn Carolaym Salazar Fajardo Hanna Jang Juwon Lee Yeonkyung Kim Gowun Kim Donghyeon Kim Effect of optimized transcranial direct current stimulation on motor cortex activation in patients with sub-acute or chronic stroke: a study protocol for a single-blinded cross-over randomized control trial Frontiers in Neuroscience brain modeling stroke non-invasive brain stimulation transcranial direct current stimulation neurorehabilitation |
| title | Effect of optimized transcranial direct current stimulation on motor cortex activation in patients with sub-acute or chronic stroke: a study protocol for a single-blinded cross-over randomized control trial |
| title_full | Effect of optimized transcranial direct current stimulation on motor cortex activation in patients with sub-acute or chronic stroke: a study protocol for a single-blinded cross-over randomized control trial |
| title_fullStr | Effect of optimized transcranial direct current stimulation on motor cortex activation in patients with sub-acute or chronic stroke: a study protocol for a single-blinded cross-over randomized control trial |
| title_full_unstemmed | Effect of optimized transcranial direct current stimulation on motor cortex activation in patients with sub-acute or chronic stroke: a study protocol for a single-blinded cross-over randomized control trial |
| title_short | Effect of optimized transcranial direct current stimulation on motor cortex activation in patients with sub-acute or chronic stroke: a study protocol for a single-blinded cross-over randomized control trial |
| title_sort | effect of optimized transcranial direct current stimulation on motor cortex activation in patients with sub acute or chronic stroke a study protocol for a single blinded cross over randomized control trial |
| topic | brain modeling stroke non-invasive brain stimulation transcranial direct current stimulation neurorehabilitation |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1328727/full |
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