BMP-2 Long-Term Stimulation of Human Pre-Osteoblasts Induces Osteogenic Differentiation and Promotes Transdifferentiation and Bone Remodeling Processes

BMP-2 Long-Term Stimulation of Human Pre-Osteoblasts Induces Osteogenic Differentiation and Promotes Transdifferentiation and Bone Remodeling Processes

Bone morphogenic protein (BMP-) 2 plays an important role in the regeneration of bone defects by promoting osteogenic differentiation. However, several animal studies have reported adverse side effects of BMP-2, including osteoclast activation, induction of peroxisome proliferator- activated recepto...

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Bibliographic Details
Main Authors: Lena-Christin Ingwersen, Marcus Frank, Hendrik Naujokat, Klaas Loger, Rainer Bader, Anika Jonitz-Heincke
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
BMP-2
pre-osteoblasts
osteoblastogenesis
bone regeneration
bone homeostasis
intracellular vacuoles
Online Access:https://www.mdpi.com/1422-0067/23/6/3077

Internet

https://www.mdpi.com/1422-0067/23/6/3077

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