Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases
Comorbidity, a co-incidence of several disorders in an individual, is a common phenomenon. Their development is governed by multiple factors, including genetic variation. The current study was set up to look at associations between isolated and comorbid diseases of bronchial asthma and hypertension,...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2018-12-01
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| Series: | Journal of Integrative Bioinformatics |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/jib-2018-0052 |
| _version_ | 1818733568690487296 |
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| author | Bragina Elena Yu. Goncharova Irina A. Garaeva Anna F. Nemerov Evgeniy V. Babovskaya Anastasija A. Karpov Andrey B. Semenova Yulia V. Zhalsanova Irina Z. Gomboeva Densema E. Saik Olga V. Zolotareva Olga I. Ivanisenko Vladimir A. Dosenko Victor E. Hofestaedt Ralf Freidin Maxim B. |
| author_facet | Bragina Elena Yu. Goncharova Irina A. Garaeva Anna F. Nemerov Evgeniy V. Babovskaya Anastasija A. Karpov Andrey B. Semenova Yulia V. Zhalsanova Irina Z. Gomboeva Densema E. Saik Olga V. Zolotareva Olga I. Ivanisenko Vladimir A. Dosenko Victor E. Hofestaedt Ralf Freidin Maxim B. |
| author_sort | Bragina Elena Yu. |
| collection | DOAJ |
| description | Comorbidity, a co-incidence of several disorders in an individual, is a common phenomenon. Their development is governed by multiple factors, including genetic variation. The current study was set up to look at associations between isolated and comorbid diseases of bronchial asthma and hypertension, on one hand, and single nucleotide polymorphisms associated with regulation of gene expression (eQTL), on the other hand. A total of 96 eQTL SNPs were genotyped in 587 Russian individuals. Bronchial asthma alone was found to be associated with rs1927914 (TLR4), rs1928298 (intergenic variant), and rs1980616 (SERPINA1); hypertension alone was found to be associated with rs11065987 (intergenic variant); rs2284033 (IL2RB), rs11191582 (NT5C2), and rs11669386 (CARD8); comorbidity between asthma and hypertension was found to be associated with rs1010461 (ANG/RNASE4), rs7038716, rs7026297 (LOC105376244), rs7025144 (intergenic variant), and rs2022318 (intergenic variant). The results suggest that genetic background of comorbidity of asthma and hypertension is different from genetic backgrounds of both diseases manifesting isolated. |
| first_indexed | 2024-12-17T23:51:32Z |
| format | Article |
| id | doaj.art-f958540e670b4ea0a8ee0a4e50e3a860 |
| institution | Directory Open Access Journal |
| issn | 1613-4516 |
| language | English |
| last_indexed | 2024-12-17T23:51:32Z |
| publishDate | 2018-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Journal of Integrative Bioinformatics |
| spelling | doaj.art-f958540e670b4ea0a8ee0a4e50e3a8602022-12-21T21:28:11ZengDe GruyterJournal of Integrative Bioinformatics1613-45162018-12-0115410556810.1515/jib-2018-0052jib-2018-0052Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid DiseasesBragina Elena Yu.0Goncharova Irina A.1Garaeva Anna F.2Nemerov Evgeniy V.3Babovskaya Anastasija A.4Karpov Andrey B.5Semenova Yulia V.6Zhalsanova Irina Z.7Gomboeva Densema E.8Saik Olga V.9Zolotareva Olga I.10Ivanisenko Vladimir A.11Dosenko Victor E.12Hofestaedt Ralf13Freidin Maxim B.14Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, RussiaResearch Institute of Medical Genetics, Tomsk NRMC, Tomsk, RussiaResearch Institute of Medical Genetics, Tomsk NRMC, Tomsk, RussiaSiberian State Medical University, Tomsk, RussiaSiberian State Medical University, Tomsk, RussiaSeversk Biophysical Research Centre of the Federal Medico-Biological Agency, Seversk, RussiaSeversk Clinical Hospital, Siberian Federal Research and Clinical Centre of the Federal Medico-Biological Agency, Seversk, RussiaResearch Institute of Medical Genetics, Tomsk NRMC, Tomsk, RussiaResearch Institute of Medical Genetics, Tomsk NRMC, Tomsk, RussiaThe Federal Research Center Institute of Cytology and Genetics, The Siberian Branch of the Russian Academy of Sciences, Novosibirsk, RussiaBielefeld University, Bioinformatics/Medical Informatics Department, Bielefeld, GermanyThe Federal Research Center Institute of Cytology and Genetics, The Siberian Branch of the Russian Academy of Sciences, Novosibirsk, RussiaBogomoletz Institute of Physiology, National Academy of Science, Kiev, UkraineBielefeld University, Bioinformatics/Medical Informatics Department, Bielefeld, GermanyResearch Institute of Medical Genetics, Tomsk NRMC, Tomsk, RussiaComorbidity, a co-incidence of several disorders in an individual, is a common phenomenon. Their development is governed by multiple factors, including genetic variation. The current study was set up to look at associations between isolated and comorbid diseases of bronchial asthma and hypertension, on one hand, and single nucleotide polymorphisms associated with regulation of gene expression (eQTL), on the other hand. A total of 96 eQTL SNPs were genotyped in 587 Russian individuals. Bronchial asthma alone was found to be associated with rs1927914 (TLR4), rs1928298 (intergenic variant), and rs1980616 (SERPINA1); hypertension alone was found to be associated with rs11065987 (intergenic variant); rs2284033 (IL2RB), rs11191582 (NT5C2), and rs11669386 (CARD8); comorbidity between asthma and hypertension was found to be associated with rs1010461 (ANG/RNASE4), rs7038716, rs7026297 (LOC105376244), rs7025144 (intergenic variant), and rs2022318 (intergenic variant). The results suggest that genetic background of comorbidity of asthma and hypertension is different from genetic backgrounds of both diseases manifesting isolated.https://doi.org/10.1515/jib-2018-0052comorbiditybronchial asthmahypertensioneqtlsnp |
| spellingShingle | Bragina Elena Yu. Goncharova Irina A. Garaeva Anna F. Nemerov Evgeniy V. Babovskaya Anastasija A. Karpov Andrey B. Semenova Yulia V. Zhalsanova Irina Z. Gomboeva Densema E. Saik Olga V. Zolotareva Olga I. Ivanisenko Vladimir A. Dosenko Victor E. Hofestaedt Ralf Freidin Maxim B. Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases Journal of Integrative Bioinformatics comorbidity bronchial asthma hypertension eqtl snp |
| title | Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases |
| title_full | Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases |
| title_fullStr | Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases |
| title_full_unstemmed | Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases |
| title_short | Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases |
| title_sort | molecular relationships between bronchial asthma and hypertension as comorbid diseases |
| topic | comorbidity bronchial asthma hypertension eqtl snp |
| url | https://doi.org/10.1515/jib-2018-0052 |
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