Long-term risk of all-cause mortality in live kidney donors: a matched cohort study
Background Long-term outcomes of live kidney donors remain controversial, although this information is crucial for selecting potential donors. Thus, this study compared the long-term risk of all-cause mortality between live kidney donors and healthy control. Methods We performed a retrospective coho...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2022-01-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://www.krcp-ksn.org/upload/pdf/j-krcp-21-042.pdf |
| _version_ | 1811311948954861568 |
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| author | Eunjeong Kang Sehoon Park Jina Park Yaerim Kim Minsu Park Kwangsoo Kim Hyo Jeong Kim Miyeun Han Jang-Hee Cho Jung Pyo Lee Sik Lee Soo Wan Kim Sang Min Park Dong-Wan Chae Ho Jun Chin Yong Chul Kim Yon Su Kim Insun Choi Hajeong Lee |
| author_facet | Eunjeong Kang Sehoon Park Jina Park Yaerim Kim Minsu Park Kwangsoo Kim Hyo Jeong Kim Miyeun Han Jang-Hee Cho Jung Pyo Lee Sik Lee Soo Wan Kim Sang Min Park Dong-Wan Chae Ho Jun Chin Yong Chul Kim Yon Su Kim Insun Choi Hajeong Lee |
| author_sort | Eunjeong Kang |
| collection | DOAJ |
| description | Background Long-term outcomes of live kidney donors remain controversial, although this information is crucial for selecting potential donors. Thus, this study compared the long-term risk of all-cause mortality between live kidney donors and healthy control. Methods We performed a retrospective cohort study including donors from seven tertiary hospitals in South Korea. Persons who underwent voluntary health screening were included as controls. We created a matched control group considering age, sex, era, body mass index, baseline hypertension, diabetes, estimated glomerular filtration rate, and dipstick albuminuria. The study outcome was progression to end-stage kidney disease (ESKD), and all-cause mortality as identified in the linked claims database. Results We screened 1,878 kidney donors and 78,115 health screening examinees from 2003 to 2016. After matching, 1,701 persons remained in each group. The median age of the matched study subjects was 44 years, and 46.6% were male. Among the study subjects, 2.7% and 16.6% had underlying diabetes and hypertension, respectively. There were no ESKD events in the matched donor and control groups. There were 24 (1.4%) and 12 mortality cases (0.7%) in the matched donor and control groups, respectively. In the age-sex adjusted model, the risk for all-cause mortality was significantly higher in the donor group than in the control group. However, the significance was not retained after socioeconomic status was included as a covariate (adjusted hazard ratio, 1.82; 95% confidence interval, 0.87–3.80). Conclusion All-cause mortality was similar in live kidney donors and matched non-donor healthy controls with similar health status and socioeconomic status in the Korean population. |
| first_indexed | 2024-04-13T10:27:55Z |
| format | Article |
| id | doaj.art-f959080145bb4e34b03242ae05124647 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 2211-9140 |
| language | English |
| last_indexed | 2024-04-13T10:27:55Z |
| publishDate | 2022-01-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-f959080145bb4e34b03242ae051246472022-12-22T02:50:16ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322211-91402022-01-0141110211310.23876/j.krcp.21.0426079Long-term risk of all-cause mortality in live kidney donors: a matched cohort studyEunjeong Kang0Sehoon Park1Jina Park2Yaerim Kim3Minsu Park4Kwangsoo Kim5Hyo Jeong Kim6Miyeun Han7Jang-Hee Cho8Jung Pyo Lee9Sik Lee10Soo Wan Kim11Sang Min Park12Dong-Wan Chae13Ho Jun Chin14Yong Chul Kim15Yon Su Kim16Insun Choi17Hajeong Lee18 Department of Internal Medicine, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea Department of Biomedical Science, Seoul National University College of Medicine, Seoul, Republic of Korea Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Republic of Korea Department of Statistics, Keimyung University, Daegu, Republic of Korea Transdisciplinary Department of Medicine & Advanced Technology, Seoul National University Hospital, Seoul, Republic of Korea Division of Healthcare Technology Assessment Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Republic of Korea Department of Internal Medicine, Hallym University Hangang Sacred Heart Hospital, Seoul, Republic of Korea Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea Department of Internal Medicine, Jeonbuk National University Hospital, Jeonju, Republic of Korea Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea Division of Healthcare Technology Assessment Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Republic of Korea Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of KoreaBackground Long-term outcomes of live kidney donors remain controversial, although this information is crucial for selecting potential donors. Thus, this study compared the long-term risk of all-cause mortality between live kidney donors and healthy control. Methods We performed a retrospective cohort study including donors from seven tertiary hospitals in South Korea. Persons who underwent voluntary health screening were included as controls. We created a matched control group considering age, sex, era, body mass index, baseline hypertension, diabetes, estimated glomerular filtration rate, and dipstick albuminuria. The study outcome was progression to end-stage kidney disease (ESKD), and all-cause mortality as identified in the linked claims database. Results We screened 1,878 kidney donors and 78,115 health screening examinees from 2003 to 2016. After matching, 1,701 persons remained in each group. The median age of the matched study subjects was 44 years, and 46.6% were male. Among the study subjects, 2.7% and 16.6% had underlying diabetes and hypertension, respectively. There were no ESKD events in the matched donor and control groups. There were 24 (1.4%) and 12 mortality cases (0.7%) in the matched donor and control groups, respectively. In the age-sex adjusted model, the risk for all-cause mortality was significantly higher in the donor group than in the control group. However, the significance was not retained after socioeconomic status was included as a covariate (adjusted hazard ratio, 1.82; 95% confidence interval, 0.87–3.80). Conclusion All-cause mortality was similar in live kidney donors and matched non-donor healthy controls with similar health status and socioeconomic status in the Korean population.http://www.krcp-ksn.org/upload/pdf/j-krcp-21-042.pdfend-stage kidney diseaseliving donorsmortalityrisk assessmentprognosis |
| spellingShingle | Eunjeong Kang Sehoon Park Jina Park Yaerim Kim Minsu Park Kwangsoo Kim Hyo Jeong Kim Miyeun Han Jang-Hee Cho Jung Pyo Lee Sik Lee Soo Wan Kim Sang Min Park Dong-Wan Chae Ho Jun Chin Yong Chul Kim Yon Su Kim Insun Choi Hajeong Lee Long-term risk of all-cause mortality in live kidney donors: a matched cohort study Kidney Research and Clinical Practice end-stage kidney disease living donors mortality risk assessment prognosis |
| title | Long-term risk of all-cause mortality in live kidney donors: a matched cohort study |
| title_full | Long-term risk of all-cause mortality in live kidney donors: a matched cohort study |
| title_fullStr | Long-term risk of all-cause mortality in live kidney donors: a matched cohort study |
| title_full_unstemmed | Long-term risk of all-cause mortality in live kidney donors: a matched cohort study |
| title_short | Long-term risk of all-cause mortality in live kidney donors: a matched cohort study |
| title_sort | long term risk of all cause mortality in live kidney donors a matched cohort study |
| topic | end-stage kidney disease living donors mortality risk assessment prognosis |
| url | http://www.krcp-ksn.org/upload/pdf/j-krcp-21-042.pdf |
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