Implications of the microbiome in the development and treatment of pancreatic cancer: Thinking outside of the box by looking inside the gut
Pancreatic ductal adenocarcinoma is the third leading cause of cancer-related death in the United States. As one of the most lethal cancer types, the prognosis for patients diagnosed with pancreatic cancer remains dismal and novel investigations are urgently needed. Evidence for an association of mi...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558620301895 |
| _version_ | 1828931552121192448 |
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| author | Qin Yu Christian Jobin Ryan M. Thomas |
| author_facet | Qin Yu Christian Jobin Ryan M. Thomas |
| author_sort | Qin Yu |
| collection | DOAJ |
| description | Pancreatic ductal adenocarcinoma is the third leading cause of cancer-related death in the United States. As one of the most lethal cancer types, the prognosis for patients diagnosed with pancreatic cancer remains dismal and novel investigations are urgently needed. Evidence for an association of microbes with pancreatic cancer risk, development, treatment response, and post-treatment survivorship is rapidly developing. Herein, we provide an overview on the role of the microbiome as it relates to the natural history of pancreatic cancer, including host immune interactions, alterations in metabolism, direct carcinogenic effect, and its role in treatment response. |
| first_indexed | 2024-12-14T00:48:40Z |
| format | Article |
| id | doaj.art-f95a2723e6164c258bcc8705509f1673 |
| institution | Directory Open Access Journal |
| issn | 1476-5586 |
| language | English |
| last_indexed | 2024-12-14T00:48:40Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj.art-f95a2723e6164c258bcc8705509f16732022-12-21T23:23:58ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55862021-02-01232246256Implications of the microbiome in the development and treatment of pancreatic cancer: Thinking outside of the box by looking inside the gutQin Yu0Christian Jobin1Ryan M. Thomas2Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USADepartment of Medicine, University of Florida College of Medicine, Gainesville, FL, USA; Department of Infectious Diseases and Immunology, University of Florida College of Medicine, Gainesville, FL, USA; Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, USADepartment of Surgery, University of Florida College of Medicine, Gainesville, FL, USA; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL, USA; Corresponding author.Pancreatic ductal adenocarcinoma is the third leading cause of cancer-related death in the United States. As one of the most lethal cancer types, the prognosis for patients diagnosed with pancreatic cancer remains dismal and novel investigations are urgently needed. Evidence for an association of microbes with pancreatic cancer risk, development, treatment response, and post-treatment survivorship is rapidly developing. Herein, we provide an overview on the role of the microbiome as it relates to the natural history of pancreatic cancer, including host immune interactions, alterations in metabolism, direct carcinogenic effect, and its role in treatment response.http://www.sciencedirect.com/science/article/pii/S1476558620301895Pancreatic ductal adenocarcinomaMicrobiotaOncobiomeMicrobiomeCarcinogenesis |
| spellingShingle | Qin Yu Christian Jobin Ryan M. Thomas Implications of the microbiome in the development and treatment of pancreatic cancer: Thinking outside of the box by looking inside the gut Neoplasia: An International Journal for Oncology Research Pancreatic ductal adenocarcinoma Microbiota Oncobiome Microbiome Carcinogenesis |
| title | Implications of the microbiome in the development and treatment of pancreatic cancer: Thinking outside of the box by looking inside the gut |
| title_full | Implications of the microbiome in the development and treatment of pancreatic cancer: Thinking outside of the box by looking inside the gut |
| title_fullStr | Implications of the microbiome in the development and treatment of pancreatic cancer: Thinking outside of the box by looking inside the gut |
| title_full_unstemmed | Implications of the microbiome in the development and treatment of pancreatic cancer: Thinking outside of the box by looking inside the gut |
| title_short | Implications of the microbiome in the development and treatment of pancreatic cancer: Thinking outside of the box by looking inside the gut |
| title_sort | implications of the microbiome in the development and treatment of pancreatic cancer thinking outside of the box by looking inside the gut |
| topic | Pancreatic ductal adenocarcinoma Microbiota Oncobiome Microbiome Carcinogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S1476558620301895 |
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