Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

Abstract Background The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response. The pathway is indispensable for the development of secretory cells by facilitating protein folding and enhancing secretory capacity. In the immune system, it is known to function in dendrit...

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Bibliographic Details
Main Authors: Jhuma Pramanik, Xi Chen, Gozde Kar, Johan Henriksson, Tomás Gomes, Jong-Eun Park, Kedar Natarajan, Kerstin B. Meyer, Zhichao Miao, Andrew N. J. McKenzie, Bidesh Mahata, Sarah A. Teichmann
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Genome Medicine
Subjects:
IRE1a-XBP1 pathway
IRE1a
XBP1
T helper cell activation
Genome-wide XBP1 chromatin occupancy
Th2 lymphocyte proliferation
Online Access:http://link.springer.com/article/10.1186/s13073-018-0589-3

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