Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary glands: Two additional cases not harboring MAML2 gene rearrangement
Sclerosing mucoepidermoid carcinoma with eosinophilia (SMCE) is a rare subgroup of mucoepidermoid carcinoma characterized by dense stromal sclerosis and marked eosinophil infiltration. We herein describe two Japanese cases of SMCE. The patients were a 60 year-old female and a 67 year-old female, and...
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Elsevier
2021-09-01
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| Series: | Human Pathology: Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214330021000754 |
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| author | Hiroshi Harada Masashi Takeda Yohko Kohno Shin-ichi Nakatsuka Kenji Mishima Akira Kurose |
| author_facet | Hiroshi Harada Masashi Takeda Yohko Kohno Shin-ichi Nakatsuka Kenji Mishima Akira Kurose |
| author_sort | Hiroshi Harada |
| collection | DOAJ |
| description | Sclerosing mucoepidermoid carcinoma with eosinophilia (SMCE) is a rare subgroup of mucoepidermoid carcinoma characterized by dense stromal sclerosis and marked eosinophil infiltration. We herein describe two Japanese cases of SMCE. The patients were a 60 year-old female and a 67 year-old female, and each had a tumor of the parotid and upper lip, both of which were successfully removed with no signs of recurrence or metastasis. Histologically, the tumors consisted of round or polygonal, and partly spindle-shaped squamous cells with generally scant keratinization, which formed small and large invasive nests in the background of dense sclerotic stroma with marked eosinophil infiltration. Only a small number of mucus-producing cells and cytoplasmic mucin vacuoles were observed. The second case was unique in its presentation of melanin pigmentation, which is rarely found in oral tumors. Fluorescence in situ hybridization for MAML2 was performed, but no clear split signals were confirmed in either case. The histogenesis of SMCE, which is possibly different to that of ordinary mucoepidermoid carcinoma or the other counterpart of sclerosing mucoepidermoid carcinoma lacking eosinophilia, is further discussed comparing their genetic backgrounds. Their pathological features and diagnostic problems are also detailed. |
| first_indexed | 2024-12-17T06:46:35Z |
| format | Article |
| id | doaj.art-f95bc320b0cc4f2dba0f663ca5a200a2 |
| institution | Directory Open Access Journal |
| issn | 2214-3300 |
| language | English |
| last_indexed | 2024-12-17T06:46:35Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Pathology: Case Reports |
| spelling | doaj.art-f95bc320b0cc4f2dba0f663ca5a200a22022-12-21T21:59:44ZengElsevierHuman Pathology: Case Reports2214-33002021-09-0125200546Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary glands: Two additional cases not harboring MAML2 gene rearrangementHiroshi Harada0Masashi Takeda1Yohko Kohno2Shin-ichi Nakatsuka3Kenji Mishima4Akira Kurose5Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; Corresponding author at: Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, 5 Zaifu, Hirosaki 036-8562, Japan.Department of Pathology, Yao Municipal Hospital, Yao, JapanDivision of Pathology, Department of Oral Diagnostic Sciences, School of Dentistry, Showa University, Tokyo, JapanDepartment of Diagnostic Pathology, Yao Tokushukai General Hospital, Yao, JapanDivision of Pathology, Department of Oral Diagnostic Sciences, School of Dentistry, Showa University, Tokyo, JapanDepartment of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki, JapanSclerosing mucoepidermoid carcinoma with eosinophilia (SMCE) is a rare subgroup of mucoepidermoid carcinoma characterized by dense stromal sclerosis and marked eosinophil infiltration. We herein describe two Japanese cases of SMCE. The patients were a 60 year-old female and a 67 year-old female, and each had a tumor of the parotid and upper lip, both of which were successfully removed with no signs of recurrence or metastasis. Histologically, the tumors consisted of round or polygonal, and partly spindle-shaped squamous cells with generally scant keratinization, which formed small and large invasive nests in the background of dense sclerotic stroma with marked eosinophil infiltration. Only a small number of mucus-producing cells and cytoplasmic mucin vacuoles were observed. The second case was unique in its presentation of melanin pigmentation, which is rarely found in oral tumors. Fluorescence in situ hybridization for MAML2 was performed, but no clear split signals were confirmed in either case. The histogenesis of SMCE, which is possibly different to that of ordinary mucoepidermoid carcinoma or the other counterpart of sclerosing mucoepidermoid carcinoma lacking eosinophilia, is further discussed comparing their genetic backgrounds. Their pathological features and diagnostic problems are also detailed.http://www.sciencedirect.com/science/article/pii/S2214330021000754Sclerosing mucoepidermoid carcinoma with eosinophiliaMAML2Salivary glandMelanin pigmentation |
| spellingShingle | Hiroshi Harada Masashi Takeda Yohko Kohno Shin-ichi Nakatsuka Kenji Mishima Akira Kurose Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary glands: Two additional cases not harboring MAML2 gene rearrangement Human Pathology: Case Reports Sclerosing mucoepidermoid carcinoma with eosinophilia MAML2 Salivary gland Melanin pigmentation |
| title | Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary glands: Two additional cases not harboring MAML2 gene rearrangement |
| title_full | Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary glands: Two additional cases not harboring MAML2 gene rearrangement |
| title_fullStr | Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary glands: Two additional cases not harboring MAML2 gene rearrangement |
| title_full_unstemmed | Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary glands: Two additional cases not harboring MAML2 gene rearrangement |
| title_short | Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary glands: Two additional cases not harboring MAML2 gene rearrangement |
| title_sort | sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary glands two additional cases not harboring maml2 gene rearrangement |
| topic | Sclerosing mucoepidermoid carcinoma with eosinophilia MAML2 Salivary gland Melanin pigmentation |
| url | http://www.sciencedirect.com/science/article/pii/S2214330021000754 |
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