Metalloproteinases and Tissue Inhibitors in Generalized Myasthenia Gravis. A Preliminary Study
Introduction: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have recently been proposed as promising biomarkers in different immune-mediated disorders. We evaluated the plasma levels of MMP-9 and MMP-2 and their tissue inhibitors TIMP-1 and TIMP-2 in a patients...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Serija: | Brain Sciences |
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| Online dostop: | https://www.mdpi.com/2076-3425/12/11/1439 |
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| author | Vincenzo Di Stefano Chiara Tubiolo Andrea Gagliardo Rosalia Lo Presti Maria Montana Massimiliano Todisco Antonino Lupica Gregorio Caimi Cristina Tassorelli Brigida Fierro Filippo Brighina Giuseppe Cosentino |
| author_facet | Vincenzo Di Stefano Chiara Tubiolo Andrea Gagliardo Rosalia Lo Presti Maria Montana Massimiliano Todisco Antonino Lupica Gregorio Caimi Cristina Tassorelli Brigida Fierro Filippo Brighina Giuseppe Cosentino |
| author_sort | Vincenzo Di Stefano |
| collection | DOAJ |
| description | Introduction: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have recently been proposed as promising biomarkers in different immune-mediated disorders. We evaluated the plasma levels of MMP-9 and MMP-2 and their tissue inhibitors TIMP-1 and TIMP-2 in a patients’ cohort with generalized myasthenia gravis (MG). Methods: Plasma concentrations of MMP-9, MMP-2, TIMP-1 and TIMP-2 were evaluated in 14 patients with generalized MG and 13 age- and sex-matched healthy controls. The severity of disease was assessed by the modified Osserman classification. Results: Compared to the healthy subjects, MG patients had increased plasma concentrations of MMP-9, but reduced plasma levels of MMP-2 and TIMP-1. MG patients also showed a positive correlation between MMP-2 concentrations and disease severity. An increase in MMP-9 levels and MMP-9/TIMP-1 ratio and a decrease in MMP-2 levels and MMP-2/TIMP-2 ratio were detected in patients with generalized MG. Higher levels of MMP-2 correlated with greater disease severity. Discussion: Our preliminary findings suggest that MMPs and TIMPs could play a role in the pathogenesis of MG and might be associated with the risk of clinical deterioration. |
| first_indexed | 2024-03-09T19:14:46Z |
| format | Article |
| id | doaj.art-f95dba0fec894593b02cfdd5e5e7d3b8 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T19:14:46Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-f95dba0fec894593b02cfdd5e5e7d3b82023-11-24T03:55:58ZengMDPI AGBrain Sciences2076-34252022-10-011211143910.3390/brainsci12111439Metalloproteinases and Tissue Inhibitors in Generalized Myasthenia Gravis. A Preliminary StudyVincenzo Di Stefano0Chiara Tubiolo1Andrea Gagliardo2Rosalia Lo Presti3Maria Montana4Massimiliano Todisco5Antonino Lupica6Gregorio Caimi7Cristina Tassorelli8Brigida Fierro9Filippo Brighina10Giuseppe Cosentino11Department of Biomedicine, Neuroscience and Advanced Diagnostic (BIND), University of Palermo, 90127 Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostic (BIND), University of Palermo, 90127 Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostic (BIND), University of Palermo, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostic (BIND), University of Palermo, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostic (BIND), University of Palermo, 90127 Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostic (BIND), University of Palermo, 90127 Palermo, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, ItalyIntroduction: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have recently been proposed as promising biomarkers in different immune-mediated disorders. We evaluated the plasma levels of MMP-9 and MMP-2 and their tissue inhibitors TIMP-1 and TIMP-2 in a patients’ cohort with generalized myasthenia gravis (MG). Methods: Plasma concentrations of MMP-9, MMP-2, TIMP-1 and TIMP-2 were evaluated in 14 patients with generalized MG and 13 age- and sex-matched healthy controls. The severity of disease was assessed by the modified Osserman classification. Results: Compared to the healthy subjects, MG patients had increased plasma concentrations of MMP-9, but reduced plasma levels of MMP-2 and TIMP-1. MG patients also showed a positive correlation between MMP-2 concentrations and disease severity. An increase in MMP-9 levels and MMP-9/TIMP-1 ratio and a decrease in MMP-2 levels and MMP-2/TIMP-2 ratio were detected in patients with generalized MG. Higher levels of MMP-2 correlated with greater disease severity. Discussion: Our preliminary findings suggest that MMPs and TIMPs could play a role in the pathogenesis of MG and might be associated with the risk of clinical deterioration.https://www.mdpi.com/2076-3425/12/11/1439matrix metalloproteinasesanti-AChR antibodiesmyasthenia gravisneuromuscular junction |
| spellingShingle | Vincenzo Di Stefano Chiara Tubiolo Andrea Gagliardo Rosalia Lo Presti Maria Montana Massimiliano Todisco Antonino Lupica Gregorio Caimi Cristina Tassorelli Brigida Fierro Filippo Brighina Giuseppe Cosentino Metalloproteinases and Tissue Inhibitors in Generalized Myasthenia Gravis. A Preliminary Study Brain Sciences matrix metalloproteinases anti-AChR antibodies myasthenia gravis neuromuscular junction |
| title | Metalloproteinases and Tissue Inhibitors in Generalized Myasthenia Gravis. A Preliminary Study |
| title_full | Metalloproteinases and Tissue Inhibitors in Generalized Myasthenia Gravis. A Preliminary Study |
| title_fullStr | Metalloproteinases and Tissue Inhibitors in Generalized Myasthenia Gravis. A Preliminary Study |
| title_full_unstemmed | Metalloproteinases and Tissue Inhibitors in Generalized Myasthenia Gravis. A Preliminary Study |
| title_short | Metalloproteinases and Tissue Inhibitors in Generalized Myasthenia Gravis. A Preliminary Study |
| title_sort | metalloproteinases and tissue inhibitors in generalized myasthenia gravis a preliminary study |
| topic | matrix metalloproteinases anti-AChR antibodies myasthenia gravis neuromuscular junction |
| url | https://www.mdpi.com/2076-3425/12/11/1439 |
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