| Summary: | Author SummaryGenome sequencing has led to the discovery of many new gene products, proteins. These discoveries hold tremendous potential for totally new approaches to the diagnosis and treatment of disease. To realize this potential, one important step is to understand the function of the thousands of proteins whose function is currently unknown. One of these proteins of unknown function is human DJ-1, a protein that appears to play a protective role against Parkinson and other neurodegenerative diseases. Here we present a computational approach to the classification by function of DJ-1 and its family members. Eight DJ-1 family members, all with similar 3-D structure, are analyzed. Three different probable functional classes emerge from this analysis on six of the family members, all with a simple calculation.
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