The Alteration of Subtelomeric DNA Methylation in Aging-Related Diseases
The telomere is located at the end of the chromosome and consists of a non-coding, repetitive DNA sequence. As the cell divides, the length of telomere gradually decreases. A very short telomere can terminate mitosis, and thus telomere length becomes a hallmark of cellular aging. The 500 kb region o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-01-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fgene.2018.00697/full |
| _version_ | 1811268994044264448 |
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| author | Haochang Hu Bin Li Shiwei Duan |
| author_facet | Haochang Hu Bin Li Shiwei Duan |
| author_sort | Haochang Hu |
| collection | DOAJ |
| description | The telomere is located at the end of the chromosome and consists of a non-coding, repetitive DNA sequence. As the cell divides, the length of telomere gradually decreases. A very short telomere can terminate mitosis, and thus telomere length becomes a hallmark of cellular aging. The 500 kb region of each autosomal arm terminal is the so-called subtelomeric region. Both telomere and subtelomere have high-density DNA repeats. Telomeres do not contain genes or CpG sequences, while subtelomeres contain small amounts of genes and high-density CpG sequences, and DNA methylation often occurs in subtelomeres. Previous studies have shown that aberrant methylation of subtelomeric DNA exists in many diseases, and it has a certain effect on the regulation of telomere length. In this review, we focus on the correlation between subtelomeric DNA methylation and aging-related diseases. We also summarize the relationship between subtelomeric methylation and telomere length in different diseases. |
| first_indexed | 2024-04-12T21:34:05Z |
| format | Article |
| id | doaj.art-f95f0bddea424238bf4edc66942fa9c9 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-12T21:34:05Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-f95f0bddea424238bf4edc66942fa9c92022-12-22T03:15:58ZengFrontiers Media S.A.Frontiers in Genetics1664-80212019-01-01910.3389/fgene.2018.00697421721The Alteration of Subtelomeric DNA Methylation in Aging-Related DiseasesHaochang HuBin LiShiwei DuanThe telomere is located at the end of the chromosome and consists of a non-coding, repetitive DNA sequence. As the cell divides, the length of telomere gradually decreases. A very short telomere can terminate mitosis, and thus telomere length becomes a hallmark of cellular aging. The 500 kb region of each autosomal arm terminal is the so-called subtelomeric region. Both telomere and subtelomere have high-density DNA repeats. Telomeres do not contain genes or CpG sequences, while subtelomeres contain small amounts of genes and high-density CpG sequences, and DNA methylation often occurs in subtelomeres. Previous studies have shown that aberrant methylation of subtelomeric DNA exists in many diseases, and it has a certain effect on the regulation of telomere length. In this review, we focus on the correlation between subtelomeric DNA methylation and aging-related diseases. We also summarize the relationship between subtelomeric methylation and telomere length in different diseases.https://www.frontiersin.org/article/10.3389/fgene.2018.00697/fullepigenetic modificationsubtelomeric DNA methylationtelomere lengthtelomeraseage-related disease |
| spellingShingle | Haochang Hu Bin Li Shiwei Duan The Alteration of Subtelomeric DNA Methylation in Aging-Related Diseases Frontiers in Genetics epigenetic modification subtelomeric DNA methylation telomere length telomerase age-related disease |
| title | The Alteration of Subtelomeric DNA Methylation in Aging-Related Diseases |
| title_full | The Alteration of Subtelomeric DNA Methylation in Aging-Related Diseases |
| title_fullStr | The Alteration of Subtelomeric DNA Methylation in Aging-Related Diseases |
| title_full_unstemmed | The Alteration of Subtelomeric DNA Methylation in Aging-Related Diseases |
| title_short | The Alteration of Subtelomeric DNA Methylation in Aging-Related Diseases |
| title_sort | alteration of subtelomeric dna methylation in aging related diseases |
| topic | epigenetic modification subtelomeric DNA methylation telomere length telomerase age-related disease |
| url | https://www.frontiersin.org/article/10.3389/fgene.2018.00697/full |
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