MAJOR DEPRESSIVE DISORDER IS ASSOCIATED WITH TYPE 2 DIABETES IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION
ABSTRACT BACKGROUND: Major depressive disorder (MDD) is commonly reported in patients with chronic hepatitis C (CHC); however, the factors behind the co-occurrence of these conditions have not been completely clarified yet. OBJECTIVE: We aimed to evaluate the frequency of mental disorders in CHC...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)
2021-12-01
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| Series: | Arquivos de Gastroenterologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032021000400476&tlng=en |
| _version_ | 1818731463644807168 |
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| author | Luciana Rodrigues da CUNHA Maria Carolina Magalhães de CASTRO Gabriela Silva DUARTE Graziela Cançado e NASCIMENTO Gifone Aguiar ROCHA Luciana Diniz SILVA |
| author_facet | Luciana Rodrigues da CUNHA Maria Carolina Magalhães de CASTRO Gabriela Silva DUARTE Graziela Cançado e NASCIMENTO Gifone Aguiar ROCHA Luciana Diniz SILVA |
| author_sort | Luciana Rodrigues da CUNHA |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: Major depressive disorder (MDD) is commonly reported in patients with chronic hepatitis C (CHC); however, the factors behind the co-occurrence of these conditions have not been completely clarified yet. OBJECTIVE: We aimed to evaluate the frequency of mental disorders in CHC patients and to investigate variables associated with MDD. METHODS: CHC patients (n=151) attending a referral Centre for hepatitis were evaluated using the Mini-International Neuropsychiatry Interview and the Cut-Annoyed-Guilty-Eye (CAGE) Questionnaire. Multivariate analysis was used to evaluate independent covariates associated with current MDD. RESULTS: Seventy-six (50.3%) patients had, at least, one current psychiatric diagnosis with MDD (33.1%) being the most common. Current MDD was independently associated with age (≤50 yr.) (OR=2.57; 95%CI=1.25-5.29; P=0.01) and type 2 diabetes mellitus (OR=2.80, 95%CI=1.17-6.70; P=0.02). Cirrhosis was associated with type 2 diabetes mellitus (OR=5.09; 95%CI=1.73-15.04; P=0.03) and current alcohol abuse/dependence (OR=2.54; 95%CI=1.04-6.22; P=0.04). DISCUSSION: MDD is associated with type 2 diabetes in CHC patients. Even in the direct-acting antivirals (DAAs) era, characterized by great perspectives for the first ample cure of a chronic viral infection, we should ensure that the screening for psychiatric disorders takes place in the course of routine clinical care of patients chronically infected with hepatitis C virus. |
| first_indexed | 2024-12-17T23:18:05Z |
| format | Article |
| id | doaj.art-f95f2d21b76f4f53b69e25cc7b18a3ee |
| institution | Directory Open Access Journal |
| issn | 1678-4219 |
| language | English |
| last_indexed | 2024-12-17T23:18:05Z |
| publishDate | 2021-12-01 |
| publisher | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) |
| record_format | Article |
| series | Arquivos de Gastroenterologia |
| spelling | doaj.art-f95f2d21b76f4f53b69e25cc7b18a3ee2022-12-21T21:28:58ZengInstituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)Arquivos de Gastroenterologia1678-42192021-12-0158447648210.1590/s0004-2803.202100000-86MAJOR DEPRESSIVE DISORDER IS ASSOCIATED WITH TYPE 2 DIABETES IN PATIENTS WITH CHRONIC HEPATITIS C INFECTIONLuciana Rodrigues da CUNHAhttps://orcid.org/0000-0001-5006-6129Maria Carolina Magalhães de CASTROhttps://orcid.org/0000-0001-7371-1979Gabriela Silva DUARTEhttps://orcid.org/0000-0003-1755-3253Graziela Cançado e NASCIMENTOhttps://orcid.org/0000-0003-2801-0326Gifone Aguiar ROCHAhttps://orcid.org/0000-0002-1858-3166Luciana Diniz SILVAhttps://orcid.org/0000-0003-0061-7361ABSTRACT BACKGROUND: Major depressive disorder (MDD) is commonly reported in patients with chronic hepatitis C (CHC); however, the factors behind the co-occurrence of these conditions have not been completely clarified yet. OBJECTIVE: We aimed to evaluate the frequency of mental disorders in CHC patients and to investigate variables associated with MDD. METHODS: CHC patients (n=151) attending a referral Centre for hepatitis were evaluated using the Mini-International Neuropsychiatry Interview and the Cut-Annoyed-Guilty-Eye (CAGE) Questionnaire. Multivariate analysis was used to evaluate independent covariates associated with current MDD. RESULTS: Seventy-six (50.3%) patients had, at least, one current psychiatric diagnosis with MDD (33.1%) being the most common. Current MDD was independently associated with age (≤50 yr.) (OR=2.57; 95%CI=1.25-5.29; P=0.01) and type 2 diabetes mellitus (OR=2.80, 95%CI=1.17-6.70; P=0.02). Cirrhosis was associated with type 2 diabetes mellitus (OR=5.09; 95%CI=1.73-15.04; P=0.03) and current alcohol abuse/dependence (OR=2.54; 95%CI=1.04-6.22; P=0.04). DISCUSSION: MDD is associated with type 2 diabetes in CHC patients. Even in the direct-acting antivirals (DAAs) era, characterized by great perspectives for the first ample cure of a chronic viral infection, we should ensure that the screening for psychiatric disorders takes place in the course of routine clinical care of patients chronically infected with hepatitis C virus.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032021000400476&tlng=enHepatitis Cchronic psychiatric disordersmajor depressive disorderanxiety disordertype 2 diabetes mellitusalcohol abuse/dependencenon-alcohol drug abuse/dependencecirrhosis |
| spellingShingle | Luciana Rodrigues da CUNHA Maria Carolina Magalhães de CASTRO Gabriela Silva DUARTE Graziela Cançado e NASCIMENTO Gifone Aguiar ROCHA Luciana Diniz SILVA MAJOR DEPRESSIVE DISORDER IS ASSOCIATED WITH TYPE 2 DIABETES IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION Arquivos de Gastroenterologia Hepatitis C chronic psychiatric disorders major depressive disorder anxiety disorder type 2 diabetes mellitus alcohol abuse/dependence non-alcohol drug abuse/dependence cirrhosis |
| title | MAJOR DEPRESSIVE DISORDER IS ASSOCIATED WITH TYPE 2 DIABETES IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION |
| title_full | MAJOR DEPRESSIVE DISORDER IS ASSOCIATED WITH TYPE 2 DIABETES IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION |
| title_fullStr | MAJOR DEPRESSIVE DISORDER IS ASSOCIATED WITH TYPE 2 DIABETES IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION |
| title_full_unstemmed | MAJOR DEPRESSIVE DISORDER IS ASSOCIATED WITH TYPE 2 DIABETES IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION |
| title_short | MAJOR DEPRESSIVE DISORDER IS ASSOCIATED WITH TYPE 2 DIABETES IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION |
| title_sort | major depressive disorder is associated with type 2 diabetes in patients with chronic hepatitis c infection |
| topic | Hepatitis C chronic psychiatric disorders major depressive disorder anxiety disorder type 2 diabetes mellitus alcohol abuse/dependence non-alcohol drug abuse/dependence cirrhosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032021000400476&tlng=en |
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