Predictive role of MMP-9 and MPO in patients with reduced glomerular filtration rate after acute coronary syndrome
Background. Coronary artery disease (CAD) persistently remains the leading cause of mortality globally. Given the severity and impact of this condition, researchers have been meticulously studying the pathogenesis of athe-rosclerosis, a principal cause behind CAD. The pathogenesis stages are complex...
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Zaslavsky O.Yu.
2023-06-01
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| Series: | Медицина неотложных состояний |
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| Online Access: | https://emergency.zaslavsky.com.ua/index.php/journal/article/view/1595 |
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| author | A.O. Bilchenko M.P. Kopytsya O.V. Petyunina I.R. Vishnevskaya Iu.V. Rodionova |
| author_facet | A.O. Bilchenko M.P. Kopytsya O.V. Petyunina I.R. Vishnevskaya Iu.V. Rodionova |
| author_sort | A.O. Bilchenko |
| collection | DOAJ |
| description | Background. Coronary artery disease (CAD) persistently remains the leading cause of mortality globally. Given the severity and impact of this condition, researchers have been meticulously studying the pathogenesis of athe-rosclerosis, a principal cause behind CAD. The pathogenesis stages are complex and multifaceted, including factors such as lipid accumulation, inflammation, and plaque formation. A particular area of active exploration pertains to the influence and role of different biomarkers, including matrix metalloproteinase 9 (MMP-9) and myeloperoxidase (MPO), on these processes. These biomarkers have been associated with the progression and destabilization of athe-rosclerotic plaques, which are central to CAD. However, the use of these biomarkers in the context of comorbidities, such as chronic kidney disease, remains an open area of research, especially in patients after myocardial infarction. Materials and methods. In our study, 96 patients who had acute coronary syndrome and subsequently undergone percutaneous coronary intervention were enrolled. They were stratified into groups (A and B) based on respective glomerular filtration rates. The primary endpoint of the study was all-cause mortality and major adverse cardiovascular and cerebrovascular events. Results. Our analysis revealed that serum levels of MPO in group B were insignificantly higher than those in group A. Conversely, the area under the receiver operating characteristic (ROC) curve for
MMP-9 in group A exhibited a significant difference, standing at 0.8 (95% confidence interval 0.609–0.991;
p = 0.039). However, the ROC curve for MPO did not yield a significant result in any group. A combined ROC curve was also generated, with the area under this curve showing a significantly higher value of 0.890 (95% confidence interval 0.805–0.975; p < 0.001). Conclusions. We found that plasma levels of the above-mentioned biomarkers do not seem to influence a decrease in glomerular filtration rate. Nonetheless, MMP-9 levels offered significant prognostic information regarding predicted outcomes. |
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| format | Article |
| id | doaj.art-f9606a8dfddc4e95b38e20c178a09644 |
| institution | Directory Open Access Journal |
| issn | 2224-0586 2307-1230 |
| language | English |
| last_indexed | 2024-03-08T09:25:32Z |
| publishDate | 2023-06-01 |
| publisher | Zaslavsky O.Yu. |
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| series | Медицина неотложных состояний |
| spelling | doaj.art-f9606a8dfddc4e95b38e20c178a096442024-01-31T10:18:19ZengZaslavsky O.Yu.Медицина неотложных состояний2224-05862307-12302023-06-0119426927310.22141/2224-0586.19.4.2023.15951595Predictive role of MMP-9 and MPO in patients with reduced glomerular filtration rate after acute coronary syndromeA.O. Bilchenko0https://orcid.org/0000-0003-3559-3128M.P. Kopytsya1https://orcid.org/0000-0003-4779-7347O.V. Petyunina2https://orcid.org/0000-0002-4716-6433I.R. Vishnevskaya3https://orcid.org/0000-0002-6914-3144Iu.V. Rodionova4https://orcid.org/0000-0001-8438-9401SI “L.T. Malaya National Therapy Institute of the National Academy of Medical Sciences of Ukraine”, Kharkiv, UkraineSI “L.T. Malaya National Therapy Institute of the National Academy of Medical Sciences of Ukraine”, Kharkiv, UkraineSI “L.T. Malaya National Therapy Institute of the National Academy of Medical Sciences of Ukraine”, Kharkiv, UkraineSI “L.T. Malaya National Therapy Institute of the National Academy of Medical Sciences of Ukraine”, Kharkiv, UkraineSI “L.T. Malaya National Therapy Institute of the National Academy of Medical Sciences of Ukraine”, Kharkiv, UkraineBackground. Coronary artery disease (CAD) persistently remains the leading cause of mortality globally. Given the severity and impact of this condition, researchers have been meticulously studying the pathogenesis of athe-rosclerosis, a principal cause behind CAD. The pathogenesis stages are complex and multifaceted, including factors such as lipid accumulation, inflammation, and plaque formation. A particular area of active exploration pertains to the influence and role of different biomarkers, including matrix metalloproteinase 9 (MMP-9) and myeloperoxidase (MPO), on these processes. These biomarkers have been associated with the progression and destabilization of athe-rosclerotic plaques, which are central to CAD. However, the use of these biomarkers in the context of comorbidities, such as chronic kidney disease, remains an open area of research, especially in patients after myocardial infarction. Materials and methods. In our study, 96 patients who had acute coronary syndrome and subsequently undergone percutaneous coronary intervention were enrolled. They were stratified into groups (A and B) based on respective glomerular filtration rates. The primary endpoint of the study was all-cause mortality and major adverse cardiovascular and cerebrovascular events. Results. Our analysis revealed that serum levels of MPO in group B were insignificantly higher than those in group A. Conversely, the area under the receiver operating characteristic (ROC) curve for MMP-9 in group A exhibited a significant difference, standing at 0.8 (95% confidence interval 0.609–0.991; p = 0.039). However, the ROC curve for MPO did not yield a significant result in any group. A combined ROC curve was also generated, with the area under this curve showing a significantly higher value of 0.890 (95% confidence interval 0.805–0.975; p < 0.001). Conclusions. We found that plasma levels of the above-mentioned biomarkers do not seem to influence a decrease in glomerular filtration rate. Nonetheless, MMP-9 levels offered significant prognostic information regarding predicted outcomes.https://emergency.zaslavsky.com.ua/index.php/journal/article/view/1595matrix metalloproteinase 9myeloperoxidaseacute coronary syndromeglomerular filtration rateoutcome |
| spellingShingle | A.O. Bilchenko M.P. Kopytsya O.V. Petyunina I.R. Vishnevskaya Iu.V. Rodionova Predictive role of MMP-9 and MPO in patients with reduced glomerular filtration rate after acute coronary syndrome Медицина неотложных состояний matrix metalloproteinase 9 myeloperoxidase acute coronary syndrome glomerular filtration rate outcome |
| title | Predictive role of MMP-9 and MPO in patients with reduced glomerular filtration rate after acute coronary syndrome |
| title_full | Predictive role of MMP-9 and MPO in patients with reduced glomerular filtration rate after acute coronary syndrome |
| title_fullStr | Predictive role of MMP-9 and MPO in patients with reduced glomerular filtration rate after acute coronary syndrome |
| title_full_unstemmed | Predictive role of MMP-9 and MPO in patients with reduced glomerular filtration rate after acute coronary syndrome |
| title_short | Predictive role of MMP-9 and MPO in patients with reduced glomerular filtration rate after acute coronary syndrome |
| title_sort | predictive role of mmp 9 and mpo in patients with reduced glomerular filtration rate after acute coronary syndrome |
| topic | matrix metalloproteinase 9 myeloperoxidase acute coronary syndrome glomerular filtration rate outcome |
| url | https://emergency.zaslavsky.com.ua/index.php/journal/article/view/1595 |
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