The Treatment of Depression in Patients with Heart Failure
This narrative review critically examines the utilization of Selective Serotonin Reuptake Inhibitors (SSRIs) in managing coexisting depression and heart failure (HF), integrating findings from various studies, clinical trials, and observational data. SSRIs, pivotal in treating mood and anxiety diso...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2024-04-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/50064 |
| _version_ | 1827277824851968000 |
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| author | Dominika Bachurska Jakub Marek Oliwia Grygorczuk Zuzanna Czach |
| author_facet | Dominika Bachurska Jakub Marek Oliwia Grygorczuk Zuzanna Czach |
| author_sort | Dominika Bachurska |
| collection | DOAJ |
| description |
This narrative review critically examines the utilization of Selective Serotonin Reuptake Inhibitors (SSRIs) in managing coexisting depression and heart failure (HF), integrating findings from various studies, clinical trials, and observational data. SSRIs, pivotal in treating mood and anxiety disorders by elevating synaptic serotonin levels, have been observed to potentially impact cardiovascular health. Specifically, SSRIs like sertraline show promise in enhancing endothelial function and exerting anti-inflammatory effects, which are beneficial in conditions like HF with preserved ejection fraction (HFpEF). Furthermore, SSRIs demonstrate favorable outcomes in reducing platelet aggregation and modulating the renin-angiotensin-aldosterone system (RAAS), suggesting a multifaceted role in HF management. However, their safety profile, particularly concerning bleeding risks, QTc prolongation, and drug interactions, necessitates careful consideration. Despite theoretical and molecular evidence supporting SSRIs' beneficial effects in HF, clinical data remain inconclusive, highlighting the need for further research. This review aims to provide a comprehensive understanding of SSRIs' effectiveness, safety, and potential benefits in treating depression and HF, offering insights for evidence-based decision-making and future research directions.
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| first_indexed | 2024-04-24T07:43:01Z |
| format | Article |
| id | doaj.art-f960d3d00bb24a8588d84527f5ddaba6 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-04-24T07:43:01Z |
| publishDate | 2024-04-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-f960d3d00bb24a8588d84527f5ddaba62024-04-19T10:54:06ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062024-04-016610.12775/JEHS.2024.66.003The Treatment of Depression in Patients with Heart FailureDominika Bachurska0Jakub Marek1Oliwia Grygorczuk2Zuzanna Czach3Faculty of Medicine, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland2nd Department of Clinical Radiology, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, PolandFaculty of Medicine, Medical University of Lodz, al. Tadeusza Kościuszki 4, 90-419 Łódź, PolandFaculty of Medicine, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland This narrative review critically examines the utilization of Selective Serotonin Reuptake Inhibitors (SSRIs) in managing coexisting depression and heart failure (HF), integrating findings from various studies, clinical trials, and observational data. SSRIs, pivotal in treating mood and anxiety disorders by elevating synaptic serotonin levels, have been observed to potentially impact cardiovascular health. Specifically, SSRIs like sertraline show promise in enhancing endothelial function and exerting anti-inflammatory effects, which are beneficial in conditions like HF with preserved ejection fraction (HFpEF). Furthermore, SSRIs demonstrate favorable outcomes in reducing platelet aggregation and modulating the renin-angiotensin-aldosterone system (RAAS), suggesting a multifaceted role in HF management. However, their safety profile, particularly concerning bleeding risks, QTc prolongation, and drug interactions, necessitates careful consideration. Despite theoretical and molecular evidence supporting SSRIs' beneficial effects in HF, clinical data remain inconclusive, highlighting the need for further research. This review aims to provide a comprehensive understanding of SSRIs' effectiveness, safety, and potential benefits in treating depression and HF, offering insights for evidence-based decision-making and future research directions. https://apcz.umk.pl/JEHS/article/view/50064Selective Serotonin Reuptake InhibitorsDepressionHeart FailureEndothelial DysfunctionDrug Interactions |
| spellingShingle | Dominika Bachurska Jakub Marek Oliwia Grygorczuk Zuzanna Czach The Treatment of Depression in Patients with Heart Failure Journal of Education, Health and Sport Selective Serotonin Reuptake Inhibitors Depression Heart Failure Endothelial Dysfunction Drug Interactions |
| title | The Treatment of Depression in Patients with Heart Failure |
| title_full | The Treatment of Depression in Patients with Heart Failure |
| title_fullStr | The Treatment of Depression in Patients with Heart Failure |
| title_full_unstemmed | The Treatment of Depression in Patients with Heart Failure |
| title_short | The Treatment of Depression in Patients with Heart Failure |
| title_sort | treatment of depression in patients with heart failure |
| topic | Selective Serotonin Reuptake Inhibitors Depression Heart Failure Endothelial Dysfunction Drug Interactions |
| url | https://apcz.umk.pl/JEHS/article/view/50064 |
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