Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death

Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death

HIV has been reported to be cytotoxic in vitro and in lymph node infection models. Using a computational approach, we found that partial inhibition of transmissions of multiple virions per cell could lead to increased numbers of live infected cells. If the number of viral DNA copies remains above on...

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Bibliographic Details
Main Authors: Laurelle Jackson, Jessica Hunter, Sandile Cele, Isabella Markham Ferreira, Andrew C Young, Farina Karim, Rajhmun Madansein, Kaylesh J Dullabh, Chih-Yuan Chen, Noel J Buckels, Yashica Ganga, Khadija Khan, Mikael Boulle, Gila Lustig, Richard A Neher, Alex Sigal
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
HIV induced cell death
cell-to-cell spread
Lymph node
viral fitness
multiple Infections per cell
Online Access:https://elifesciences.org/articles/30134

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