Current Nutritional and Pharmacological Approaches for Attenuating Sarcopenia
Sarcopenia is characterized by a gradual slowing of movement due to loss of muscle mass and quality, decreased power and strength, increased risk of injury from falls, and often weakness. This review will focus on recent research trends in nutritional and pharmacological approaches to controlling sa...
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| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/19/2422 |
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| author | Kunihiro Sakuma Kento Hamada Akihiko Yamaguchi Wataru Aoi |
| author_facet | Kunihiro Sakuma Kento Hamada Akihiko Yamaguchi Wataru Aoi |
| author_sort | Kunihiro Sakuma |
| collection | DOAJ |
| description | Sarcopenia is characterized by a gradual slowing of movement due to loss of muscle mass and quality, decreased power and strength, increased risk of injury from falls, and often weakness. This review will focus on recent research trends in nutritional and pharmacological approaches to controlling sarcopenia. Because nutritional studies in humans are fairly limited, this paper includes many results from nutritional studies in mammals. The combination of resistance training with supplements containing amino acids is the gold standard for preventing sarcopenia. Amino acid (HMB) supplementation alone has no significant effect on muscle strength or muscle mass in sarcopenia, but the combination of HMB and exercise (whole body vibration stimulation) is likely to be effective. Tea catechins, soy isoflavones, and ursolic acid are interesting candidates for reducing sarcopenia, but both more detailed basic research on this treatment and clinical studies in humans are needed. Vitamin D supplementation has been shown not to improve sarcopenia in elderly individuals who are not vitamin D-deficient. Myostatin inhibitory drugs have been tried in many neuromuscular diseases, but increases in muscle mass and strength are less likely to be expected. Validation of myostatin inhibitory antibodies in patients with sarcopenia has been positive, but excessive expectations are not warranted. |
| first_indexed | 2024-03-10T21:47:13Z |
| format | Article |
| id | doaj.art-f962e733e0544663b6d399e6af9c8b2b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T21:47:13Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-f962e733e0544663b6d399e6af9c8b2b2023-11-19T14:13:37ZengMDPI AGCells2073-44092023-10-011219242210.3390/cells12192422Current Nutritional and Pharmacological Approaches for Attenuating SarcopeniaKunihiro Sakuma0Kento Hamada1Akihiko Yamaguchi2Wataru Aoi3Institute for Liberal Arts, Environment and Society, Tokyo Institute of Technology, Meguro-ku, Tokyo 152-8550, JapanInstitute for Liberal Arts, Environment and Society, Tokyo Institute of Technology, Meguro-ku, Tokyo 152-8550, JapanDepartment of Physical Therapy, Health Sciences University of Hokkaido, Kanazawa, Ishikari-Tobetsu, Hokkaido 061-0293, JapanLaboratory of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, JapanSarcopenia is characterized by a gradual slowing of movement due to loss of muscle mass and quality, decreased power and strength, increased risk of injury from falls, and often weakness. This review will focus on recent research trends in nutritional and pharmacological approaches to controlling sarcopenia. Because nutritional studies in humans are fairly limited, this paper includes many results from nutritional studies in mammals. The combination of resistance training with supplements containing amino acids is the gold standard for preventing sarcopenia. Amino acid (HMB) supplementation alone has no significant effect on muscle strength or muscle mass in sarcopenia, but the combination of HMB and exercise (whole body vibration stimulation) is likely to be effective. Tea catechins, soy isoflavones, and ursolic acid are interesting candidates for reducing sarcopenia, but both more detailed basic research on this treatment and clinical studies in humans are needed. Vitamin D supplementation has been shown not to improve sarcopenia in elderly individuals who are not vitamin D-deficient. Myostatin inhibitory drugs have been tried in many neuromuscular diseases, but increases in muscle mass and strength are less likely to be expected. Validation of myostatin inhibitory antibodies in patients with sarcopenia has been positive, but excessive expectations are not warranted.https://www.mdpi.com/2073-4409/12/19/2422sarcopeniaHMBcatechinursolic acidvitamin Dmyostatin |
| spellingShingle | Kunihiro Sakuma Kento Hamada Akihiko Yamaguchi Wataru Aoi Current Nutritional and Pharmacological Approaches for Attenuating Sarcopenia Cells sarcopenia HMB catechin ursolic acid vitamin D myostatin |
| title | Current Nutritional and Pharmacological Approaches for Attenuating Sarcopenia |
| title_full | Current Nutritional and Pharmacological Approaches for Attenuating Sarcopenia |
| title_fullStr | Current Nutritional and Pharmacological Approaches for Attenuating Sarcopenia |
| title_full_unstemmed | Current Nutritional and Pharmacological Approaches for Attenuating Sarcopenia |
| title_short | Current Nutritional and Pharmacological Approaches for Attenuating Sarcopenia |
| title_sort | current nutritional and pharmacological approaches for attenuating sarcopenia |
| topic | sarcopenia HMB catechin ursolic acid vitamin D myostatin |
| url | https://www.mdpi.com/2073-4409/12/19/2422 |
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