Move Your Body toward Healthy Aging: Potential Neuroprotective Mechanisms of Irisin in Alzheimer’s Disease
Alzheimer’s disease (AD) is the leading cause of dementia in older adults, having a significant global burden and increasing prevalence. Current treatments for AD only provide symptomatic relief and do not cure the disease. Physical activity has been extensively studied as a potential preventive mea...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/15/12440 |
| _version_ | 1797586641905254400 |
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| author | Tatiani Bellettini-Santos Hemily Batista-Silva Clairton Marcolongo-Pereira Fernanda Cristina de Abreu Quintela-Castro Rafael Mazioli Barcelos Kelly Cristina Mota Braga Chiepe Joamyr Victor Rossoni Roberta Passamani-Ambrosio Bruno Spalenza da Silva Orlando Chiarelli-Neto Michelle Lima Garcez |
| author_facet | Tatiani Bellettini-Santos Hemily Batista-Silva Clairton Marcolongo-Pereira Fernanda Cristina de Abreu Quintela-Castro Rafael Mazioli Barcelos Kelly Cristina Mota Braga Chiepe Joamyr Victor Rossoni Roberta Passamani-Ambrosio Bruno Spalenza da Silva Orlando Chiarelli-Neto Michelle Lima Garcez |
| author_sort | Tatiani Bellettini-Santos |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is the leading cause of dementia in older adults, having a significant global burden and increasing prevalence. Current treatments for AD only provide symptomatic relief and do not cure the disease. Physical activity has been extensively studied as a potential preventive measure against cognitive decline and AD. Recent research has identified a hormone called irisin, which is produced during exercise, that has shown promising effects on cognitive function. Irisin acts on the brain by promoting neuroprotection by enhancing the growth and survival of neurons. It also plays a role in metabolism, energy regulation, and glucose homeostasis. Furthermore, irisin has been found to modulate autophagy, which is a cellular process involved in the clearance of protein aggregates, which are a hallmark of AD. Additionally, irisin has been shown to protect against cell death, apoptosis, oxidative stress, and neuroinflammation, all of which are implicated in AD pathogenesis. However, further research is needed to fully understand the mechanisms and therapeutic potential of irisin in AD. Despite the current gaps in knowledge, irisin holds promise as a potential therapeutic target for slowing cognitive decline and improving quality of life in AD patients. |
| first_indexed | 2024-03-11T00:24:58Z |
| format | Article |
| id | doaj.art-f964ad9186c5406ba4ac5be5b2d8424d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T00:24:58Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f964ad9186c5406ba4ac5be5b2d8424d2023-11-18T23:05:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124151244010.3390/ijms241512440Move Your Body toward Healthy Aging: Potential Neuroprotective Mechanisms of Irisin in Alzheimer’s DiseaseTatiani Bellettini-Santos0Hemily Batista-Silva1Clairton Marcolongo-Pereira2Fernanda Cristina de Abreu Quintela-Castro3Rafael Mazioli Barcelos4Kelly Cristina Mota Braga Chiepe5Joamyr Victor Rossoni6Roberta Passamani-Ambrosio7Bruno Spalenza da Silva8Orlando Chiarelli-Neto9Michelle Lima Garcez10Graduate Program of Research and Extension (CEPEG), University Center of Espirito Santo, Espírito Santo 29703-858, BrazilGraduate Program of Research and Extension (CEPEG), University Center of Espirito Santo, Espírito Santo 29703-858, BrazilGraduate Program of Research and Extension (CEPEG), University Center of Espirito Santo, Espírito Santo 29703-858, BrazilGraduate Program of Research and Extension (CEPEG), University Center of Espirito Santo, Espírito Santo 29703-858, BrazilGraduate Program of Research and Extension (CEPEG), University Center of Espirito Santo, Espírito Santo 29703-858, BrazilGraduate Program of Research and Extension (CEPEG), University Center of Espirito Santo, Espírito Santo 29703-858, BrazilGraduate Program of Research and Extension (CEPEG), University Center of Espirito Santo, Espírito Santo 29703-858, BrazilGraduate Program of Research and Extension (CEPEG), University Center of Espirito Santo, Espírito Santo 29703-858, BrazilGraduate Program of Research and Extension (CEPEG), University Center of Espirito Santo, Espírito Santo 29703-858, BrazilGraduate Program of Research and Extension (CEPEG), University Center of Espirito Santo, Espírito Santo 29703-858, BrazilGraduate Program of Research and Extension (CEPEG), University Center of Espirito Santo, Espírito Santo 29703-858, BrazilAlzheimer’s disease (AD) is the leading cause of dementia in older adults, having a significant global burden and increasing prevalence. Current treatments for AD only provide symptomatic relief and do not cure the disease. Physical activity has been extensively studied as a potential preventive measure against cognitive decline and AD. Recent research has identified a hormone called irisin, which is produced during exercise, that has shown promising effects on cognitive function. Irisin acts on the brain by promoting neuroprotection by enhancing the growth and survival of neurons. It also plays a role in metabolism, energy regulation, and glucose homeostasis. Furthermore, irisin has been found to modulate autophagy, which is a cellular process involved in the clearance of protein aggregates, which are a hallmark of AD. Additionally, irisin has been shown to protect against cell death, apoptosis, oxidative stress, and neuroinflammation, all of which are implicated in AD pathogenesis. However, further research is needed to fully understand the mechanisms and therapeutic potential of irisin in AD. Despite the current gaps in knowledge, irisin holds promise as a potential therapeutic target for slowing cognitive decline and improving quality of life in AD patients.https://www.mdpi.com/1422-0067/24/15/12440Alzheimer’s diseaseapoptosisautophagycell deathexerciseirisin |
| spellingShingle | Tatiani Bellettini-Santos Hemily Batista-Silva Clairton Marcolongo-Pereira Fernanda Cristina de Abreu Quintela-Castro Rafael Mazioli Barcelos Kelly Cristina Mota Braga Chiepe Joamyr Victor Rossoni Roberta Passamani-Ambrosio Bruno Spalenza da Silva Orlando Chiarelli-Neto Michelle Lima Garcez Move Your Body toward Healthy Aging: Potential Neuroprotective Mechanisms of Irisin in Alzheimer’s Disease International Journal of Molecular Sciences Alzheimer’s disease apoptosis autophagy cell death exercise irisin |
| title | Move Your Body toward Healthy Aging: Potential Neuroprotective Mechanisms of Irisin in Alzheimer’s Disease |
| title_full | Move Your Body toward Healthy Aging: Potential Neuroprotective Mechanisms of Irisin in Alzheimer’s Disease |
| title_fullStr | Move Your Body toward Healthy Aging: Potential Neuroprotective Mechanisms of Irisin in Alzheimer’s Disease |
| title_full_unstemmed | Move Your Body toward Healthy Aging: Potential Neuroprotective Mechanisms of Irisin in Alzheimer’s Disease |
| title_short | Move Your Body toward Healthy Aging: Potential Neuroprotective Mechanisms of Irisin in Alzheimer’s Disease |
| title_sort | move your body toward healthy aging potential neuroprotective mechanisms of irisin in alzheimer s disease |
| topic | Alzheimer’s disease apoptosis autophagy cell death exercise irisin |
| url | https://www.mdpi.com/1422-0067/24/15/12440 |
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