In vivo / in vitro Correlation of Pharmacokinetics of Gentamicin, Vancomycin, Teicoplanin and Doripenem in a Bovine Blood Hemodialysis Model

In vivo / in vitro Correlation of Pharmacokinetics of Gentamicin, Vancomycin, Teicoplanin and Doripenem in a Bovine Blood Hemodialysis Model

Background: Elimination of a drug during renal replacement therapy is not only dependent on flow rates, molecular size and protein binding, but is often influenced by difficult to predict drug membrane interactions. In vitro models allow for extensive profiling of drug clearance using a wide array o...

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Bibliographic Details
Main Authors: M G Vossen, S Pferschy, C Milacek, M Haidinger, Mario Karolyi, Zoltan Vass, Heinz Burgmann, Alexandra Maier-Salamon, S G Wicha, W Jäger, M Zeitlinger, T Stimpfl, T Wittek, F Thalhammer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
bovine blood
pharmacokinetics
chronic hemodialysis
clearance
antimicrobial agent
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.702455/full

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